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    Interleukin-17 BINDING PROTEINS
    52.
    发明专利
    Interleukin-17 BINDING PROTEINS 未知

    公开(公告)号：NZ594514A

    公开(公告)日：2013-06-28

    申请号：NZ59451410

    申请日：2010-03-05

    Applicant: ABBOTT LAB

    Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L

    IPC: A61K39/395

    Abstract: 594514 IL-17 BINDING PROTEINS Provided is binding protein comprising an antigen binding domain, wherein said binding protein binds human IL-17, said antigen binding domain comprises six CDRs with defined sequences. Corresponding DNA sequences for the variable domains are also provided. The antibodies can be used to treat a variety of diseases, including inflammation, autoimmunity and cancer.

    THERAPEUTIC DLL4 BINDING PROTEINS
    53.
    发明专利
    THERAPEUTIC DLL4 BINDING PROTEINS 未知

    公开(公告)号：ZA201206552B

    公开(公告)日：2013-05-29

    申请号：ZA201206552

    申请日：2012-08-31

    Applicant: ABBOTT LAB

    Inventor： LI YINGCHUN ,  MORGAN-LAPPE SUSAN ,  HSIEH CHUNG-MING ,  GU JIJIE JAMES ,  CHEN MING-JIU

    IPC: C07K20060101

    Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

    TNF-alpha binding proteins
    54.
    发明专利
    TNF-alpha binding proteins 未知

    公开(公告)号：AU2011338313A1

    公开(公告)日：2013-05-02

    申请号：AU2011338313

    申请日：2011-12-08

    Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

    Inventor： HSIEH CHUNG-MING ,  GOODREAU CARRIE ,  GHAYUR TARIQ ,  MOELLER ACHIM ,  BOSE SAHANA

    IPC: C12P21/06

    Abstract: TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.

    IL-1 BINDING PROTEINS
    55.
    发明专利
    IL-1 BINDING PROTEINS 未知

    公开(公告)号：NZ593905A

    公开(公告)日：2013-03-28

    申请号：NZ59390510

    申请日：2010-01-29

    Applicant: ABBOTT LAB

    Inventor： WU CHENGBIN ,  HSIEH CHUNG-MING

    IPC: C07K16/24

    Abstract: 593905 Provided are humanized IL-1 antibodies, which can be used to treat various immunological diseases, including arthritis, asthma, arthropathy, various infections and mental disorders, among others. Further provided are corresponding peptide encoding DNA sequences, vectors containing them and host cells comprising the vectors.

    IMPROVED ANTIBODY LIBRARIES
    56.
    发明专利
    IMPROVED ANTIBODY LIBRARIES 未知

    公开(公告)号：NZ591543A

    公开(公告)日：2012-11-30

    申请号：NZ59154309

    申请日：2009-09-30

    Applicant: ABBOTT LAB

    Inventor： HSIEH CHUNG-MING ,  KUTSKOVA YULIYA A ,  MEMMOTT JOHN E

    IPC: C07H21/04 ,  C40B40/08

    Abstract: Disclosed are in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.

    IMPROVED MAMMALIAN EXPRESSION VECTORS AND USES THEREOF
    57.
    发明专利
    IMPROVED MAMMALIAN EXPRESSION VECTORS AND USES THEREOF 未知

    公开(公告)号：NZ586576A

    公开(公告)日：2012-08-31

    申请号：NZ58657609

    申请日：2009-01-15

    Applicant: ABBOTT LAB

    Inventor： HSIEH CHUNG-MING

    IPC: C12N15/00 ,  C12N5/10 ,  C12N15/74 ,  C12P21/00 ,  C12P21/06

    Abstract: An expression vector that comprises: (a) An OriP origin of replication from Epstein-Barr virus (EBV); (b) And SV40 origin of replication; (c) An insertion site for a gene of interest; (d) An EF-1alpha promoter operably linked to the insertion site; and optionally (e) A nucleic acid sequence encoding an antibody. The antibody can be an anti-TNFalpha antibody, an anti-IL-18 antibody or and anti-IL-12 antibody. The vector can be used to express the antibody in a mammalian host cell selected from COS or HEK-293-6E cells.

    IMPROVED METHOD OF RNA DISPLAY RNA
    59.
    发明专利
    IMPROVED METHOD OF RNA DISPLAY RNA 未知

    公开(公告)号：HK1159250A1

    公开(公告)日：2012-07-27

    申请号：HK11113810

    申请日：2011-12-21

    Applicant: ABBOTT LAB

    Inventor： HSIEH CHUNG-MING ,  KUTSKOVA YULIYA A ,  MEMMOTT JOHN E

    IPC: G01N20060101 ,  C12N20060101

    Abstract: The present invention features improved methods of in vitro RNA display to allow reliable expression and selection of scFv antibody molecules from expression libraries. The improved methods, in part, involve the use of mildly reducing conditions, which favor of scFv intra-chain disulphide bond and thus correct folding of the scFv antibody molecules. Although particularly suited to expression and selection of scFv antibody molecules, the methods of the invention are also expedient for in vitro RNA display of all classes of protein.

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