公开(公告)号：DE69435315D1

公开(公告)日：2010-10-28

申请号：DE69435315

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH JANE B ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  G01N35/02 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

公开(公告)号：DE69434638T2

公开(公告)日：2006-12-14

申请号：DE69434638

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ALGONQUIN ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  G01N35/02 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.

公开(公告)号：CA2132959C

公开(公告)日：2006-01-24

申请号：CA2132959

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  RUMBAUGH WILLIAM ,  WINTER GARY E ,  HANCE ROBERT B ,  STANTON ALYN K ,  OLEKSAK CARL M ,  WATKINS WILLIAM E III ,  VICKSTROM RICHARD L ,  CLOONAN KEVIN M ,  WOHLFORD ROBERT A ,  HILLS DAVID B JR ,  SCHRIER PAUL R ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE

IPC: G01N35/00 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01F11/04 ,  G01M11/00 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/00 ,  G05D23/19 ,  H01J49/04 ,  H02P8/00 ,  H04B15/00 ,  H05B39/04 ,  H05B41/00 ,  H05B41/36

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated. continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station, whereby a mixture of the unit dose disposabl e reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assa y in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually byat least two assay procedures.

公开(公告)号：DE69333230T2

公开(公告)日：2004-08-05

申请号：DE69333230

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY RAY ,  MCDOWELL DOUGLAS D ,  RUMBAUGH WILLIAM A ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

公开(公告)号：DE69330785T2

公开(公告)日：2002-06-20

申请号：DE69330785

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： SCHMIDT LINDA S ,  SPRONK ADRIAN M ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE III ,  LAGOCKI PETER A ,  MITCHELL JAMES E ,  MARTIN RICHARD R ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  G01N1/00 ,  G01N21/25 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N33/02 ,  G01N33/483

公开(公告)号：CA2214125A1

公开(公告)日：1998-03-19

申请号：CA2214125

申请日：1997-08-28

Applicant: ABBOTT LAB

Inventor： BARNES GRADY III ,  SLESZYNSKI NEAL T ,  RAMSEY JACK F ,  MURRAY ADRIAN J ,  HOLEN JAMES T ,  GRANDONE CASS J ,  GARDNER GREGORY E ,  MURRAY DAVID W ,  GALITZ CHARLES M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  BUTTON RICHARD D ,  MITCHELL JAMES E ,  GRAY ROBERT C ,  TOTH JULIUS J ,  ARNQUIST DAVID C ,  MCCOY JIMMY D ,  DUNN CHADWICK M ,  LUOMA ROBERT P II

IPC: G01N35/02

Abstract: The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent; the embodiments disclosed also related to determination of an item of interestin a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent; embodiments also described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. An effective length of the process lane is maintained constant while a physical length of the process lane is selectively varied.

公开(公告)号：CA2172363A1

公开(公告)日：1995-03-31

申请号：CA2172363

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N37/00

Abstract: An automated, continuous and random access analytical system, having apparat us and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodolo gies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is a lso disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assa ys of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a u nit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reacti on sequence, followed by physical transfer of the unit dose disposable to a processing wo rkstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performi ng more than one scheduled assay in any order, and assay s where more than such scheduled assays are presented. The automated, continuo us and random access analytical system is also capable o f analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2613156A1

公开(公告)日：1995-03-30

申请号：CA2613156

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  YOST DAVID A ,  HILLS DAVID B ,  LAGOCKI PETER A ,  WINTER GARY E ,  VICKSTROM RICHARD L ,  STANTON ALYN K ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  MARTIN RICHARD R ,  OLEKSAK CARL M ,  MITCHELL JAMES E ,  SCHMIDT LINDA S ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  HENDRICK KENDALL B ,  WALKER EDNA S ,  SPRONK ADRIAN M ,  WOHLFORD ROBERT A ,  SMITH JANE B ,  RUMBAUGH WILLIAM D ,  MOORE LARRY W ,  MERRIAM RICHARD A ,  CLOONAN KEVIN M ,  SCHRIER PAUL R ,  CLARK FREDERICK L ,  CLEMENS JOHN M ,  MCDOWELL DOUGLAS D ,  HANCE ROBERT B ,  CLIFT GILBERT

IPC: G01N33/483 ,  G01N35/00 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N1/44 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00 ,  H01J49/04

Abstract: The invention discloses an automated liquid level sensing system for detecting the presence of liquid in a container, comprising an electrically conductive and movable probe positioned above said container; a signal source electrically connected to said probe, said signal source capable of energizing said probe thereby causing said probe to transmit said electrical signal at a given frequency; a receiving antenna and means for transferring said received electrical signal from said receiving antenna to an analyzing means; wherein analyzing said received electrical signal includes: (1) means for detecting changes in received signal amplitude, wherein said means for detecting changes in received signal amplitude includes:(a) means for multiplying said received signal by a reference signal, said reference signal having a frequency substantially equal to the frequency of the transmitted signal; and (b) a low pass filter through which is passed said multiplied received signal; and (2) means for measuring rate of change of said change in received signal amplitude; and means connected to said analyzing means for indicating that liquid has been detected. The invention further discloses a method of automatically detecting the presence of liquid in a container using the system of the invention. An automated liquid sensing system for use in a clinical analysis system having a pipettor for dispensing or aspirating liquid in a container, the pipettor being electrically conductive and moveable vertically into the container, using the automated liquid sensing system of the invention further comprising a means electrically connected to the pipettor for applying a RF signal thereto and causing the pipettor to radiate an electromagnetic field, the propagation of which changes when the pipettor contacts the surface of the liquid in the container is further disclosed.

公开(公告)号：AU3934993A

公开(公告)日：1993-11-08

申请号：AU3934993

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： KANEWSKE WILLIAM J III ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  LAGOCKI PETER A ,  MARTIN RICHARD E ,  MITCHELL JAMES E ,  MOORE LARRY E ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  YOST DAVID A

IPC: B29C45/00 ,  B29C45/42 ,  G01N21/03 ,  G01N21/64 ,  G01N33/53 ,  G01N35/02 ,  B29D23/22 ,  G01N35/06

公开(公告)号：CA2132960A1

公开(公告)日：1993-10-14

申请号：CA2132960

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LOGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH B JANE ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY R ,  RUMBAUGH WILLIAM ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

Abstract: 2132960 9320440 PCTABS00027 An automated, continuous and random access analytical system, havin apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample (26), reagents (30) to a reaction vessel (34) without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable (34) to a process work station (46), whereby a mixture of the unit dose disposable reagents and sample (34) are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.