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    51.
    发明专利
    未知

    公开(公告)号：DK0922050T3

    公开(公告)日：2003-11-24

    申请号：DK97921411

    申请日：1997-04-25

    Applicant: ABBOTT LAB

    Inventor： OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY ,  ELLIOTT RICHARD L

    IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

    Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

    3-Descladinose-2,3-anhydroerythromycin derivatives and medicaments
    53.
    发明专利
    3-Descladinose-2,3-anhydroerythromycin derivatives and medicaments 未知

    公开(公告)号：NZ332321A

    公开(公告)日：2000-04-28

    申请号：NZ33232197

    申请日：1997-04-25

    Applicant: ABBOTT LAB

    Inventor： ELLIOTT RICHARD L ,  OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY

    IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

    Abstract: A compound or pharmaceutically acceptable salt or ester thereof selected from the formulae I, II, III and IV is claimed wherein: R1 is -H, -OH, -O-alkyl, -O-CO-alkyl, -O-CO-NH2, -O-CO-NH-CO-alkyl, -O-CO-NH-SO2-alkyl; R2 is H or a hydroxyl-protecting group; R6 is H or alkyl; R is H, optionally substituted alkyl, cycloalkyl or optionally substituted aryl or heteroaryl; W is absent or is -O-, -NH-CO-, -N=CH-, -NH- or -N-alkyl-; A, B, D and E are independently H, optionally substituted alkyl, cycloalkyl or optionally substituted aryl or heteroaryl, heterocycloalkyl or a group listed under option (b) as defined in the specification further substituted by -M-R5 or AB, AD, AE, BD, BE or DE can be taken together with the atom(s) to form a 3-7 membered ring optionally containing a heteroatom(s) as defined in the specification. A pharmaceutical composition containing a compound as defined above useful in treating bacteria infections is claimed.

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