公开(公告)号：ZA964711B

公开(公告)日：1997-12-08

申请号：ZA964711

申请日：1996-06-06

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  A61K ,  C07K

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：ZA9604710B

公开(公告)日：1997-12-08

申请号：ZA9604710

申请日：1996-06-06

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  C07K ,  A61K

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/101

公开(公告)号：FI964446A

公开(公告)日：1997-01-03

申请号：FI964446

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K

Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

公开(公告)号：FI964448A0

公开(公告)日：1996-11-05

申请号：FI964448

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：ZA953584B

公开(公告)日：1996-11-04

申请号：ZA953584

申请日：1995-05-04

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  AMBERG WILHELM ,  BERNARD HARALD ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  JANITSCHKE LOTHAR ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS ,  POTZOLLI BERND DE

IPC: A61K38/08 ,  A61P35/00 ,  A61K38/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K ,  A61K

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：NO952366L

公开(公告)日：1995-06-15

申请号：NO952366

申请日：1995-06-15

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07

公开(公告)号：NO952366A

公开(公告)日：1995-06-15

申请号：NO952366

申请日：1995-06-15

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K5/0205

公开(公告)号：NO944419D0

公开(公告)日：1994-11-18

申请号：NO944419

申请日：1994-11-18

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K5/062 ,  C07K5/08 ,  C07K5/083 ,  C07K5/087 ,  C07K5/10 ,  C07K5/103 ,  C07K5/107 ,  C07K7/06 ,  C07K

Abstract: Novel derivates of dolastatin of formula (I) in which R , R , A, B, D, E, F, G, K, X, t, u, v, and w have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：SI9300661A

公开(公告)日：1994-06-30

申请号：SI9300661

申请日：1993-12-16

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K37/02 ,  C07K1/04 ,  C07K1/06

公开(公告)号：CA2151953A1

公开(公告)日：1994-06-23

申请号：CA2151953

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K31/425 ,  A61K38/04 ,  C07D277/56 ,  C07D417/12

Abstract: Novel peptides of folmula (I) in which R1, R2, X, A, R3, B, D, E, R7, M, Q, a, b and d have the meanings statod in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.