公开(公告)号：CA2300478A1

公开(公告)日：1999-02-18

申请号：CA2300478

申请日：1998-08-11

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  C07K5/062 ,  C07K5/078 ,  C07K5/06 ,  A61K38/05

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders and have formula (I).

公开(公告)号：AU6896398A

公开(公告)日：1998-11-11

申请号：AU6896398

申请日：1998-04-13

Applicant: COR THERAPEUTICS INC

Inventor： SU TING ,  ZHU BING-YAN ,  SCARBOROUGH ROBERT M JR

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K5/065 ,  C07K5/068 ,  C07K5/078 ,  C07K5/087 ,  C07K5/09 ,  C07K5/06 ,  A61K38/05

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：MX9709910A

公开(公告)日：1998-07-31

申请号：MX9709910

申请日：1997-12-08

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  LAIBELMAN ALAN M ,  SINHA UMA ,  ZHU BING-YAN

IPC: A61P7/02 ,  C07C279/24 ,  A61K38/00 ,  C07C281/06 ,  C07C309/30 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  C07K05/06 ,  A61K38/55

Abstract: Se describen compuestos novedosos, sus sales y composiciones relacionadas con los mismos que tienen actividad contra el factor Xa de mamífero; los compuestos son utiles in vitro o in vivo para prevenir o tratar trastornos de coagulacion.

公开(公告)号：AU781880B2

公开(公告)日：2005-06-16

申请号：AU7486600

申请日：2000-09-15

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  JIA ZHAOZHONG JON ,  HUANG WENRONG ,  SONG YONGHONG ,  KANTER JAMES ,  SCARBOROUGH ROBERT M

IPC: C07D231/14 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P7/02 ,  A61P7/04 ,  A61P43/00 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D277/20 ,  C07D277/56 ,  C07D333/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07D231/00

公开(公告)号：AU1462602A

公开(公告)日：2002-04-08

申请号：AU1462602

申请日：2001-10-01

Applicant: COR THERAPEUTICS INC

Inventor： ZHANG PENGLIE ,  ZUCKETT JINGMEI FAN ,  BAO LIANG ,  SCARBOROUGH ROBERT M JR ,  ZHU BING-YAN

IPC: A61P7/00 ,  C07D213/74 ,  C07D213/81 ,  C07D409/12 ,  C07D213/00

Abstract: Novel quaternary amine containing compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

公开(公告)号：AU743544B2

公开(公告)日：2002-01-31

申请号：AU4904797

申请日：1997-10-10

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/02 ,  A61P9/10 ,  C07D417/12 ,  C07F5/02 ,  C07K5/06 ,  C07D417/14 ,  A61K31/425

公开(公告)号：NZ500352A

公开(公告)日：2001-10-26

申请号：NZ50035298

申请日：1998-04-13

Applicant: COR THERAPEUTICS INC

Inventor： SU TING ,  ZHU BING-YAN ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K5/065 ,  C07K5/068 ,  C07K5/078 ,  C07K5/087 ,  C07K5/09 ,  C07K5/06 ,  A61K38/05

Abstract: Compounds of the given formula suitable for treating conditions characterized by undesired thrombosis, unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, thrombotic stroke, embolic stroke, disseminated intravascular coagulation, septic shock, deep venous thrombosis, pulmonary embolism, or reocclusion or restenosis of reperfused coronary arteries.

公开(公告)号：AU5078301A

公开(公告)日：2001-09-12

申请号：AU5078301

申请日：2001-02-28

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  ZHANG PENGLIE ,  WANG LINGYAN ,  HUANG WENRONG ,  GOLDMAN ERICK ,  LI WENHAO ,  ZUCKETT JINGMEI ,  SONG YONGHONG ,  SCARBOROUGH ROBERT

IPC: A61K31/443 ,  A61K31/444 ,  A61P7/02 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D333/38 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14 ,  C07D521/00 ,  C07D317/44 ,  C07D213/80 ,  C07D213/79 ,  C07D233/26 ,  C07D295/18 ,  C07C257/18 ,  C07D203/18 ,  C07D205/04 ,  C07D401/14 ,  C07D231/40 ,  C07D403/12 ,  A61K31/18 ,  A61K31/44

Abstract: Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：AU3660601A

公开(公告)日：2001-08-14

申请号：AU3660601

申请日：2001-02-01

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT

IPC: A61P7/02 ,  C07D265/36 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  A61K31/538

Abstract: Novel compounds of formula I: including its pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

公开(公告)号：AU3470501A

公开(公告)日：2001-08-14

申请号：AU3470501

申请日：2001-02-01

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT

IPC: A61P7/02 ,  C07D401/12 ,  C07D401/14 ,  A61K31/415