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    MELANIN SUPPRESSING AGENT
    52.
    发明专利
    MELANIN SUPPRESSING AGENT 失效

    公开(公告)号：JPH06271450A

    公开(公告)日：1994-09-27

    申请号：JP6420793

    申请日：1993-03-23

    Applicant: KAO CORP

    Inventor： YADA YUKIHIRO ,  KIMURA MITSUTOSHI ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI ,  OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K31/13 ,  A61K31/133 ,  A61K31/138 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07C217/28 ,  C07C217/30 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a melanin suppressing agent capable of preventing and improving melanization by acting on an epidermal melanin metabolism system and having excellent effect capable of preventing and improving stain or ephelis due to suntan, etc., and excellent in blending property to a cosmetic base. CONSTITUTION:This melanin suppressing agent contains an amine derivative of formula I (R is 4-40C straight-chain, branched chain or cyclic saturated or unsaturated hydrocarbon group; R to R are H or 1-10C hydrocarbon groups whose hydrogen atoms may be substituted with one or more OH groups) or its acid addition salt, e.g. 1-(2-hydroxyethylamino)-3-tetradesiloxy-2-propanol. The compound is blended in an amount of 0.0001-10wt.%, especially 0.001-2wt.% based on total composition of a cosmetic to provide a beautifying cosmetic excellent in effect capable of preventing and treating melanization. The compound of formula 1 is obtained by adding an amine derivative of formula 3 to a glycidyl ether derivative of formula 2.

    WRINKLE IMPROVER AND KERATINIZATION IMPROVER
    53.
    发明专利
    WRINKLE IMPROVER AND KERATINIZATION IMPROVER 失效

    公开(公告)号：JPH06271448A

    公开(公告)日：1994-09-27

    申请号：JP6060293

    申请日：1993-03-19

    Applicant: KAO CORP

    Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KUSUOKU HIROSHI ,  KAWAMATA AKIRA ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  IMOKAWA GENJI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61P17/16 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a wrinkle improver and keratinization improver excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin, hyperplasia of epidermis and abnormality of lipometabolism and excellent in recovery of normal function and retention of homeostasis. CONSTITUTION:The wrinkle improver and keratinization improver consists of an amine derivative of formula I (R is 8-40C straight-chain or branched chain hydrocarbon group which may have OH; R to R are H or 1-7C hydrocarbon group which may have OH; R is 2-6C hydrocarbon group which may have OH; X is OR , CO2R or CONR R (R to R are H or 1-20C hydrocarbon which contains O) or its acid addition salt or quaternary compound, e.g. 1-(2 hydroxyethylamino)-2,16-hexadecanediol. This compound has action capable of suppressing DNA synthesis of an epidermic cell, promoting differential induction and suppressing hyperplasia of epidermis. The compound of formula I is obtained by subjecting an alcohol of formula 2 to halogenation or sulfonic acid esterification and adding an amine of formula 4 to the resultant compound of formula 3.

    FLUORINE-MODIFIED SILICONE DERIVATIVE, ITS PRODUCTION AND COSMETIC CONTAINING THE SAME DERIVATIVE
    54.
    发明专利
    FLUORINE-MODIFIED SILICONE DERIVATIVE, ITS PRODUCTION AND COSMETIC CONTAINING THE SAME DERIVATIVE 失效

    公开(公告)号：JPH06234858A

    公开(公告)日：1994-08-23

    申请号：JP2145493

    申请日：1993-02-09

    Applicant: KAO CORP

    Inventor： OKADA JOJI ,  KAWAMATA AKIRA ,  TOKUNAGA TADAYUKI ,  TORITSUKA MAKOTO ,  ASAHI MASAHIKO

    IPC: A61K8/72 ,  A61K8/00 ,  A61K8/89 ,  A61Q1/00 ,  A61Q1/10 ,  A61Q1/12 ,  C08G77/38 ,  C08G77/385 ,  C08L83/04 ,  C08L83/08 ,  A61K7/00

    Abstract: PURPOSE:To readily and simply produce a new fluorine-modified silicone derivative exhibiting high water and oil repellency and useful, e.g. for a cosmetic excellent in feeling in use by reacting a polysiloxane partly containing SiH groups with a perfluoroalkyl group-containing unsaturated compound. CONSTITUTION:A silicone derivative containing polysiloxane units respectively represented by formula I (R is 1 to 20C aliphatic hydrocarbon, a 5 to 10C alicyclic or aromatic hydrocarbon; p is 1 to 200) and formula II (R and R are the same kind as R ; q is 0 to 200) is reacted with a perfluoroalkyl compound expressed by formula III [Rf is a 1 to 20C perfluoroalkyl or an omega- perfluoroalkyl represented by formula H(CF2)r (r is 1 to 20); X is single bond, CO, a 1 to 6C divalent hydrocarbon, etc.; Y is CO, a 1 to 6C divalent hydrocarbon, etc.; m is 2 to 16], thus readily and simply producing the objective fluorine- modified silicone derivative containing polysiloxane units respectively represented by formulae IV and I and exhibiting high water and oil repellency.

    GAMMA-PYRONE DERIVATIVE AND ULTRAVIOLET RAY ABSORBER AND COSMETIC CONTAINING THE SAME
    57.
    发明专利
    GAMMA-PYRONE DERIVATIVE AND ULTRAVIOLET RAY ABSORBER AND COSMETIC CONTAINING THE SAME 失效

    公开(公告)号：JPH04290882A

    公开(公告)日：1992-10-15

    申请号：JP5493491

    申请日：1991-03-19

    Applicant: KAO CORP

    Inventor： YAMAGUCHI MASAKAZU ,  ARANAKA KOICHI ,  KAWAMATA AKIRA

    IPC: A61K8/00 ,  A61K8/49 ,  A61Q17/04 ,  C07D309/38 ,  C09K3/00

    Abstract: PURPOSE:To obtain a new compound, capable of exhibiting ultraviolet ray absorbing action over a wide wavelength region and useful as ultraviolet ray absorbers, cosmetics, etc. CONSTITUTION:A compound expressed by formula I [R is 1-8C alkyl, 6-10C aryl, OH, 1-8C alkoxy, 2-8C alkenyloxy, 1-8C perfluoroalkyl, etc.; (n) and (m) are 0-4; (n+m) is >=1], e.g. 2-(3,4-dimethoxyphenyl)-6-phenyl-4H-pyran-4-one. Furthermore, the aforementioned compound expressed by formula I is obtained by condensing a benzoylacetone derivative expressed by formula II with a benzoic acid derivative expressed by formula III in the presence of a base such as sodium hydroxide as a catalyst in an aprotic solvent such as diethyl ether at 20-150 deg.C and then cyclodehyrating the resultant compound expressed by formula IV with a strong acid such as sulfuric acid. A cosmetic containing the above-mentioned compound is excellent in anti-suntan effects.

    SKIN DRUG FOR EXTERNAL USE
    58.
    发明专利
    SKIN DRUG FOR EXTERNAL USE 失效

    公开(公告)号：JPH04134013A

    公开(公告)日：1992-05-07

    申请号：JP25673290

    申请日：1990-09-26

    Applicant: KAO CORP

    Inventor： SHIOYA YASUSHI ,  SUZUKI YUJI ,  TAKEUCHI MASARU ,  YOSHINO KOJI ,  KAWAMATA AKIRA

    IPC: A61K8/72 ,  A61K8/00 ,  A61K8/06 ,  A61K8/34 ,  A61K8/89 ,  A61K8/891 ,  A61K8/92 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/04 ,  C08L83/04

    Abstract: PURPOSE:To obtain a safe skin drug for external use capable of providing a semitransparent or transparent state by regulating the concentration of polyols in an aqueous phase by extremely stably emulsifying an oily phase containing a silicone oil and the aqueous phase containing the aforementioned polyols using a specific siloxane derivative as an emulsifying agent. CONSTITUTION:A skin drug for external use is obtained by blending (A) 5-70wt.% oily phase ingredient containing a silicone oil with (B) 20-94.5wt.% aqueous phase ingredient containing polyols and (C) 0.5-30wt.% emulsifying agent containing a compound expressed by formula I [at least one of R to R is formula II (Q is 3-20C bifunctional hydrocarbon group; at least one of R and R is H and the rest is 1-5C hydrocarbon group) and the rest are R or XR (X is bifunctuonal hydrocarbon group containing ether bond and/or ester bond; R is l-30C straight-chain, branched chain or cyclic hydrocarbon group); l to n are numbers of 0 to 2000, R and R are H) and the rest are CH3] as essential ingredients. The resultant skin drug for external use has the above-mentioned effects.

    PRODUCTION OF ALPHA-HYDROGENORGANOPOLYSILOXANE
    60.
    发明专利
    PRODUCTION OF ALPHA-HYDROGENORGANOPOLYSILOXANE 失效

    公开(公告)号：JPH03135985A

    公开(公告)日：1991-06-10

    申请号：JP32286289

    申请日：1989-12-13

    Applicant: KAO CORP

    Inventor： YOSHINO KOJI ,  SUDA MITSUO ,  KAWAMATA AKIRA

    IPC: C07F7/12 ,  C07B61/00 ,  C07F7/08 ,  C08G77/22 ,  C08G77/38 ,  C08G77/382 ,  C08G77/385

    Abstract: PURPOSE:To obtain the title compound having chain length controlled to a fixed number by using a compound prepared by reacting a cyclic silicone with chlorosilane in the presence of active carbon substantially not containing water and a specific amount of water. CONSTITUTION:1 mol compound shown by formula I (R is alkyl, alkenyl or aryl; n is 3-10) is reacted with 1-10 mols compound shown by formula II in the presence of 1-50 wt.% active carbon dried preferably at >=100 deg.C for >=1 hour and water in a sufficient amount (0.3-3.8 mol % based on compound shown by formula II) to patially hydrolyze the compound shown by formula II and to evolve hydrogen chloride which advances ring opening reaction of the compound shown by formula I at room temperature for 1-5 hours to give a compound shown by formula III. Then this compound shown by formula III is reacted with a compound shown by formula IV[A is R or R3SiO(R2SiO)m (m is 3-20)] to give the objective compound shown by formula V.

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