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公开(公告)号：AU2012216605B2
公开(公告)日：2014-06-12
申请号：AU2012216605
申请日：2012-09-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：AU2011224119B2
公开(公告)日：2014-03-06
申请号：AU2011224119
申请日：2011-09-19
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TURNER STEPHEN , KORLACH JONAS
Abstract: The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
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公开(公告)号：AU2007289057B2
公开(公告)日：2013-06-13
申请号：AU2007289057
申请日：2007-08-31
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN
IPC: F21V9/16
Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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公开(公告)号：AU2008307617A1
公开(公告)日：2009-04-09
申请号：AU2008307617
申请日：2008-09-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , TRAVERS KEVIN , HEINER CHERYL
Abstract: Methods of separating tagged nucleic acid fragments from populations of fragments are provided. The fragments are produced from a population of tagged nucleic acids. In some cases, the population of tagged nucleic acids comprises a population of clonal nucleic acids.
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公开(公告)号：CA2687062A1
公开(公告)日：2008-11-20
申请号：CA2687062
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS
Abstract: Mitigative and remedial approaches to reduction of autofluorescence backg round noise are applied in analytical systems that rely upon sensitive measu rement of fluorescent signals from arrays of fluorescent signal sources. Suc h systems are for particular use in fluorescence based sequencing by incorpo ration systems that rely upon small numbers or individual fluorescent molecu les in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using hi ghly multiplexed, high-density optical systems to illuminate high- density s ample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are app lied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and d erivation of sequence information from such synthesis.
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Patent Agency Ranking56.发明专利
公开(公告)号：CA2642261A1
公开(公告)日：2007-08-23
申请号：CA2642261
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： DIXON JOHN , LACROIX YVES , TURNER STEPHEN , ZACCARIN DENIS , LUNDQUIST PAUL
IPC: G01J3/30
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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57.发明专利
公开(公告)号：CA2642258A1
公开(公告)日：2007-08-23
申请号：CA2642258
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LACROIX YVES , TURNER STEPHEN , FOQUET MATHIEU , MAXHAM MARK , LUNDQUIST PAUL , ZACCARIN DENIS
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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58.发明专利
公开(公告)号：AU2007215173A1
公开(公告)日：2007-08-23
申请号：AU2007215173
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： DIXON JOHN , LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS , LACROIX YVES
IPC: G01J3/30
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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公开(公告)号：CA2596495A1
公开(公告)日：2006-08-17
申请号：CA2596495
申请日：2006-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , KORLACH JONAS
IPC: G01N31/00
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60.发明公开METHODS AND SYSTEMS FOR ANALYZING FLUORESCENT MATERIALS WITH REDUCED AUTOFLUORESCENCE 审中-公开方法和系统的分析荧光材料与荧光减少OWN
公开(公告)号：EP2150806A4
公开(公告)日：2013-01-02
申请号：EP08767652
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS , ZHAO PEGIAN , TURNER STEPHEN
CPC classification number: G01N27/447 , G01N21/6452 , G01N21/6458 , G02B21/0032
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