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公开(公告)号：SG11201503365YA
公开(公告)日：2015-06-29
申请号：SG11201503365Y
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：CA2890106A1
公开(公告)日：2014-05-08
申请号：CA2890106
申请日：2013-11-01
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , KARKARE RADHIKA , MOORE MICHAEL DOUGLAS
IPC: A61K9/20 , A61K31/443 , A61K31/47 , A61K45/06
Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.
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公开(公告)号：UA102261C2
公开(公告)日：2013-06-25
申请号：UAA201102840
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：AU2011237601A1
公开(公告)日：2012-11-01
申请号：AU2011237601
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , ALARGOVA ROSSITZA GUEORGUIEVA , KAUSHIK RITU ROHIT , KADIYALA IRINA NIKOLAEVNA , YOUNG CHRISTOPHER RYAN
IPC: A61K9/20
Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2- difluorobenzo [d] [ 1,3 ] dioxol-5 -y1) cyclopropanecarboxamido)-3 -methylpyridin-2-y1)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.
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公开(公告)号：AR081760A1
公开(公告)日：2012-10-17
申请号：ARP110101172
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , ALARGOVA ROSSITZA GUEORGUIEVA , KAUSHIK RITU ROHIT , KADIYALA IRINA NIKOLAEVNA , YOUNG CHRISTOPHER RYAN
IPC: A61K31/4427 , A61P11/00
Abstract: Una composición farmacéutica para administración oral que comprende ácido 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico (compuesto 1), caracterizada por comprender: a) el compuesto de fórmula (1) en cualquiera de sus formas cristalinas I o II y/o su forma A de clorhidrato, b) un agente de relleno, c) un diluyente, d) un desintegrante, e) un surfactante, f) un lubricante, y g) al menos uno entre un ligante y un deslizante. Un método para producir dicha composición farmacéutica, a una tableta y a un forma unitaria de dosificación oral que comprenden los ingredientes de dicha composición farmacéutica, al uso dicha composición farmacéutica para la fabricación de un medicamento y a un kit que comprende dicha composición farmacéutica, tableta o unidad de dosificación con instrucciones para su utilización.
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Patent Agency Ranking
公开(公告)号：SG178337A1
公开(公告)日：2012-03-29
申请号：SG2012009080
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：MX2011001782A
公开(公告)日：2012-02-08
申请号：MX2011001782
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： YOUNG CHRISTOPHER , GROSSI ALFREDO , ROWE WILLIAM , HURTER PATRICIA , DINEHART KIRK , OVERHOFF KIRK , GROOTENHUIS PETER D , BOTFIELD MARTYN , VERWIJS MARINUS JACOBUS
IPC: A61K47/32
Abstract: La presente invención se refiere a una composición farmacéutica que comprende una dispersión sólida de N-[2,4-Bis(1,1-dimetiletil) -5-hidroxifenil]-1,4-dihidro-4-oxoquinoline-3-carboxamido, métodos de manufactura de composiciones farmacéuticas de la presente invención y métodos de administración de composición farmacéutica de la presente invención.
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公开(公告)号：CA2733908A1
公开(公告)日：2010-02-18
申请号：CA2733908
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：HRP20211752T1
公开(公告)日：2022-02-18
申请号：HRP20211752
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , ALARGOVA ROSSITZA GUEORGUIEVA , KAUSHIK RITU ROHIT , KADIYALA IRINA NIKOLAEVNA , YOUNG CHRISTOPHER RYAN
IPC: A61K9/16 , A61K9/20 , A61K9/28 , C07D213/75 , C07D405/12 , C07D405/14
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公开(公告)号：PL3150198T3
公开(公告)日：2022-01-17
申请号：PL16185289
申请日：2011-04-07
Applicant: VERTEX PHARMA
Inventor： VERWIJS MARINUS JACOBUS , ALARGOVA ROSSITZA GUEORGUIEVA , KAUSHIK RITU ROHIT , KADIYALA IRINA NIKOLAEVNA , YOUNG CHRISTOPHER RYAN
IPC: A61K9/16 , A61K9/20 , A61K9/28 , C07D213/75 , C07D405/12 , C07D405/14
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