公开(公告)号：WO2021150297A1

公开(公告)日：2021-07-29

申请号：PCT/US2020/060832

申请日：2020-11-17

Applicant: EMD MILLIPORE CORPORATION

Inventor： BERTI PEREZ, Stefano ,  DUPONT, Alison

IPC: B01D61/18 ,  C02F3/12 ,  C12M3/06 ,  B01D2313/06 ,  B01D2313/20 ,  B01D2313/58 ,  B01D2315/06 ,  C02F3/1273 ,  C12M29/04 ,  C12M47/10

Abstract: The disclosure herein relates to a TFF assembly including a baffle comprising a microporous filter within a bioreactor. The baffle may include a collection receptacle to capture a target product or waste materials within the baffle after passing through the microporous filter.

公开(公告)号：WO2020146565A1

公开(公告)日：2020-07-16

申请号：PCT/US2020/012829

申请日：2020-01-09

Applicant: EMD MILLIPORE CORPORATION

Inventor： GREENIZEN, Kurt ,  SCOTT, Christopher ,  SYDLOWSKI, Paul ,  WU, Kevin ,  AMARA, Ryan ,  MANNING, Ryan ,  GUTIERREZ, Sara ,  DOYLE, John

IPC: G01N27/447

Abstract: The embodiments disclosed herein are directed to a device and assembly useful for hand casting an electrophoretic separation medium. The device includes a cassette frame 10 comprising first and second arms or members 12,22 pivotally connected to one another. One or more hinges 35A,35B may be provided to allow the first member to swing or pivot relative to the second member 12,22 (or vice versa) between a cassette frame open position and a cassette frame closed position. The first and second members 12,22 each include a substrate 20,30 to maintain a gel interface, preferably a glass plate substrate. The assembly includes a base and clamping arms that cooperate to hold one or more cassette frames in compressed relation.

公开(公告)号：WO2020123243A9

公开(公告)日：2020-06-18

申请号：PCT/US2019/064580

申请日：2019-12-05

Applicant: EMD MILLIPORE CORPORATION

Inventor： LANDRY, Nathan ,  STRAEFFER, Gregory ,  NATALE, Matthew

IPC: B01D65/00 ,  B01D63/10 ,  B01D63/12 ,  B01D69/00

Abstract: A spiral wound membrane module, comprising a perforated core having an axially extending internal bore; at least one membrane packet comprising a folded membrane sheet defining a first outer face, a first inner face, a second outer face and a second inner face, the fold of the folded membrane sheet being a leading end of the membrane packet; a feed sheet positioned between the first and second inner faces so as to be sandwiched by the folded membrane sheet; a first permeate screen adjacent the first outer face of the membrane sheet defining a first permeate channel; a second permeate screen adjacent the second outer face of the membrane sheet defining a second permeate channel; and a fluid impermeable support coupled to the leading edge of the membrane packet. Also disclosed is a method of manufacturing the spiral wound membrane module.

公开(公告)号：WO2020101848A1

公开(公告)日：2020-05-22

申请号：PCT/US2019/057554

申请日：2019-10-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： PEREIRA, Brian ,  SARAGOSA, John ,  MULDOON, Joseph

IPC: B32B27/12 ,  B32B3/26 ,  B32B5/02 ,  B32B7/12 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36

Abstract: A material for biocontainers comprising a film formed of two or more layers forming a body to the film, the film having an interior and exterior side, and a substrate incorporated in the body of the film wherein the substrate is formed of a fibrous material, wherein each of the at least one of the two or more layers comprises an ethylene vinyl acetate resin. A non-constrained pressure test is also disclosed.

公开(公告)号：WO2020092688A1

公开(公告)日：2020-05-07

申请号：PCT/US2019/059027

申请日：2019-10-31

Applicant: EMD MILLIPORE CORPORATION

Inventor： KAS, Onur, Y. ,  NGUYEN, Thang ,  SATAV, Nitin ,  CUDDY, Martin

IPC: D01D5/00 ,  D04H1/728

Abstract: Provided herein are electrospinning apparatuses and methods for efficient production of nanofiber structures.

公开(公告)号：WO2018085070A1

公开(公告)日：2018-05-11

申请号：PCT/US2017/057856

申请日：2017-10-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： MORRISSEY, Martin

IPC: B01D35/28

Abstract: Containers for separating microcarriers from a cell culture fluid that offer a greater efficiency of filtration of cell culture fluids containing microcarriers relative to systems described in the art. The container may include a first compartment that may include a sterile collapsible bag, an inlet port providing a fluid path into the first compartment and an outlet port providing a fluid path exiting the first compartment; and a second compartment fluidly connected with the inlet port of the first compartment and including a plurality of independent or discrete microcarrier receiving regions defined by boundary walls which are partially or fully porous and having a porosity sufficient to retain the microcarriers inside the second compartment, while allowing the cell culture fluid to pass through the second compartment into the outlet port of the first compartment, where the cell culture fluid can be collected.

Abstract translation: 用于从细胞培养液分离微载体的容器相对于本领域描述的系统提供了包含微载体的细胞培养液的更高的过滤效率。 该容器可以包括第一隔室和第二隔室，第一隔室可以包括无菌可收缩袋，提供流体路径进入第一隔室的入口和提供离开第一隔室的流体路径的出口; 以及与第一隔室的入口端口流体连通并包括多个独立或离散的微载体接收区域的第二隔室，所述微载体接收区域由部分或完全多孔的边界壁限定并且具有足以将微载体保持在第二隔室内的孔隙率，而 允许细胞培养液通过第二隔室进入第一隔室的出口，在那里可以收集细胞培养液。

公开(公告)号：WO2018075142A1

公开(公告)日：2018-04-26

申请号：PCT/US2017/049075

申请日：2017-08-29

Applicant: EMD MILLIPORE CORPORATION

Inventor： GERINGER, Joseph ,  CASTRO, Robert ,  SZYK, Martin ,  DAUDENARDE, Sophie ,  ALMASIAN, Joseph

IPC: B01D46/00 ,  B01D35/00 ,  B65D59/06

Abstract: Port protection device particularly suited for an encapsulated filter unit. In certain embodiments, the protection device comprises a main body defining an internal region configured to receive a port or the like protruding from an encapsulated filter. In certain embodiments, the main body includes a slot that allows for easy removal of the protection device from the port or the like. A tube management system may be provided to receive and hold tubing. One suitable tube management system includes two spaced tangs that extend from the main body of the protection device and are configured to cooperatively receive and hold tubing between them.

Abstract translation:

端口保护装置，特别适用于封装式过滤单元。 在某些实施例中，保护装置包括限定内部区域的主体，该内部区域被配置为接收从封装过滤器突出的端口等。 在某些实施例中，主体包括狭槽，该狭槽允许从端口等容易地移除保护装置。 管道管理系统可以被提供以接收和保持管道。 一种合适的管子管理系统包括两个从保护装置的主体延伸的间隔开的柄脚，并且构造成协作地接收和保持它们之间的管。

公开(公告)号：WO2018044648A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/048193

申请日：2017-08-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： LIU, Songhua ,  LYNCH, Michael ,  SYLVIA, Ryan ,  ALMASIAN, Joseph ,  GIGLIA, Salvatore ,  MESSIER, Luc

IPC: B01D46/00 ,  B01D35/00 ,  B01D35/30 ,  B01D46/04

Abstract: A scaling tool for replicating filtration characteristics of a large-scale filtration device, the scaling tool comprising a housing having a fluid inlet and a fluid outlet, and a filter receiving region in fluid communication with the fluid inlet and the fluid outlet and configured to contain a membrane comprising one or more pleats, the filter receiving region being defined by a rigid wall framework configured to hold the one or more pleats of the membrane and compress the pleats in an amount effective to replicate the filtration performance of the large-scale filtration device. Also disclosed is a methodology for configuring a filter receiving region in a scaling tool.

Abstract translation: 一种用于复制大规模过滤装置的过滤特性的定标工具，定标工具包括具有流体入口和流体出口的壳体以及与流体入口流体连通的过滤器接收区域 和流体出口并且被构造成容纳包括一个或多个褶皱的膜，所述过滤器接收区域由刚性壁框架限定，刚性壁框架构造成保持膜的一个或多个褶皱并且以有效复制过滤的量压缩褶皱 大型过滤装置的性能。 还公开了一种用于在缩放工具中配置过滤器接收区域的方法。

公开(公告)号：WO2017087057A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/051268

申请日：2016-09-12

Applicant: EMD MILLIPORE CORPORATION

Inventor： GIGLIA, Salvatore ,  NHIEM, David

IPC: G01N15/08 ,  B01D65/10

CPC classification number: B01D65/10

Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The method includes humidifying the inlet gas stream to minimize or prevent the porous material from drying out. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen. The permeate gas stream may be subjected to a driving force such as reduced pressure to increase the flow of gases and reduce test time. Multiple porous materials can be integrity tested at the same time, such as by manifolding a plurality of them together. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.

Abstract translation: 一种完整性测试多孔材料的方法，对被测试材料无损坏。 该方法包括加湿入口气流以最小化或防止多孔材料变干。 入口气流包括至少两种气体，其中一种气体在液体中具有不同于另一种的渗透性，例如氧气和氮气。 渗透气流可以经受诸如减压的驱动力以增加气体流量并减少测试时间。 可以同时对多种多孔材料进行完整性测试，例如通过将多个多孔材料分支在一起。 完整性测试能够检测到可能损害多孔材料保留能力的超大孔或缺陷的存在。

公开(公告)号：WO2016109230A3

公开(公告)日：2016-07-07

申请号：PCT/US2015/066348

申请日：2015-12-17

Applicant: EMD MILLIPORE CORPORATION

Inventor： HUNT, Stephen G. ,  LANDRY, Nicholas ,  SZYK, Martin

IPC: G01N15/08 ,  B01D65/10 ,  G01F1/36

Abstract: The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.