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    СПОСОБ МУЛЬТИПРАЙМЕРНОЙ АМПЛИФИКАЦИИ ДЛЯ ШТРИХОВОГО КОДИРОВАНИЯ ЦЕЛЕВЫХ НУКЛЕИНОВЫХ КИСЛОТ
    61.
    发明专利
    СПОСОБ МУЛЬТИПРАЙМЕРНОЙ АМПЛИФИКАЦИИ ДЛЯ ШТРИХОВОГО КОДИРОВАНИЯ ЦЕЛЕВЫХ НУКЛЕИНОВЫХ КИСЛОТ 未知

    公开(公告)号：EA023190B1

    公开(公告)日：2016-05-31

    申请号：EA201171206

    申请日：2010-04-02

    Applicant: FLUIDIGM CORP

    Inventor： MAY ANDREW ,  CHEN PEILIN ,  WANG JUN ,  KAPER FIONA ,  ANDERSON MEGAN

    IPC: C12Q1/68

    Abstract: Вопределенныхвариантахосуществленияданноеизобретениеобеспечиваетспособыамплификации, вкоторыхнуклеотиднуюметку(и) и, факультативно, штрих-кодовуюнуклеотиднуюпоследовательностьдобавляютк целевымнуклеотиднымпоследовательностям. Вдругихвариантахосуществленияданноеизобретениеобеспечиваетмикрофлюидноеустройство, котороевключаетмножествопервыхлинийвводаи множествовторыхлинийввода. Микрофлюидноеустройствотакжевключаетмножествонаборовпервыхкамери множествонабороввторыхкамер. Каждыйнаборпервыхкамернаходитсяв жидкостнойсвязис однимизмножествапервыхлинийввода. Каждыйнаборвторыхкамернаходитсяв жидкостнойсвязис однимизмножествавторыхлинийввода. Микрофлюидноеустройстводополнительновключаетмножествопервыхплунжерныхпарв жидкостнойсвязис первойчастьюмножествавторыхлинийвводаи множествовторыхплунжерныхпарв жидкостнойсвязис второйчастьюмножествавторыхлинийввода.

    MICROFLUIDIC DEVICE WITH REACTION PRODUCT RECOVERY SYSTEM
    62.
    发明专利
    MICROFLUIDIC DEVICE WITH REACTION PRODUCT RECOVERY SYSTEM 未知

    公开(公告)号：HK1203085A1

    公开(公告)日：2015-10-16

    申请号：HK15103623

    申请日：2015-04-14

    Applicant: FLUIDIGM CORP

    Inventor： MAY ANDREW ,  ANDERSON MEGAN

    IPC: C12Q20060101

    Abstract: The present invention provides an elastomer microfluidic device that enables simultaneous amplification of multiple nucleic acid samples with multiple pairs of primers in a matrix format as well as recovery of the products e.g. for next generation sequencing. The flow of samples and reagents as well as the compartmentalization of individual reactions in the multiple channels and chambers is controlled using valves and dilation pumping / volumetric capacitive pumping.

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    63.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG10201506381RA

    公开(公告)日：2015-09-29

    申请号：SG10201506381R

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    Multi-primer amplification method for barcoding of target nucleic acids
    64.
    发明专利
    Multi-primer amplification method for barcoding of target nucleic acids 未知

    公开(公告)号：AU2010232439B2

    公开(公告)日：2015-07-16

    申请号：AU2010232439

    申请日：2010-04-02

    Applicant: FLUIDIGM CORP

    Inventor： MAY ANDREW ,  CHEN PEILIN ,  WANG JUN ,  KAPER FIONA ,  ANDERSON MEGAN

    IPC: C12Q1/68

    Abstract: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.

    66.
    发明专利
    未知

    公开(公告)号：BRPI0816393A2

    公开(公告)日：2015-03-03

    申请号：BRPI0816393

    申请日：2008-09-08

    Applicant: FLUIDIGM CORP

    Inventor： RAMAKRISHNAN RAMESH

    IPC: G01N33/48

    Abstract: The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and a reference polynucleotide, and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject.

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    67.
    发明专利
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 未知

    公开(公告)号：SG10201405756WA

    公开(公告)日：2014-11-27

    申请号：SG10201405756W

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN

    IPC: C12M1/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C12M3/00 ,  C30B7/00 ,  C30B29/58

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

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