公开(公告)号：AT304523T

公开(公告)日：2005-09-15

申请号：AT02739257

申请日：2002-05-14

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  PERNER RICHARD J ,  LARSON DANIEL P ,  KOENIG JOHN R ,  GOMTSYAN ARTHUR R ,  ZHENG GUO ZHU ,  DIDOMENICO STANLEY ,  STEWART ANDREW O ,  BAYBURT EROL K

IPC: A61K31/194 ,  A61K31/275 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/505 ,  A61P13/00 ,  A61P13/02 ,  A61P13/10 ,  A61P21/00 ,  A61P25/04 ,  A61P43/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/74 ,  C07C233/76 ,  C07C233/79 ,  C07C251/48 ,  C07C251/52 ,  C07C255/60 ,  C07C311/51 ,  C07C321/24 ,  C07D207/06 ,  C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D309/32 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/40 ,  C07D333/42 ,  C07D333/68 ,  C07D333/72 ,  A61K31/166 ,  A61K31/18

公开(公告)号：AU2004247721A1

公开(公告)日：2004-12-23

申请号：AU2004247721

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： HSU MARGARET ,  SCHMIDT ROBERT ,  BAYBURT EROL K ,  LUKIN KIRILL ,  LEANNA M ROBERT ,  LEE CHIH-HUNG ,  CHAMBOURNIER GILLES ,  CINK RUSSEL D ,  GOMTSYAN ARTHUR ,  KOENIG JOHN R

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：CA2476936A1

公开(公告)日：2003-08-28

申请号：CA2476936

申请日：2003-02-11

Applicant: ABBOTT LAB

Inventor： ZHENG GUO ZHU ,  SCHMIDT ROBERT G ,  PERNER RICHARD J ,  LEE CHIH-HUNG ,  BAYBURT EROL K ,  KOENIG JOHN R ,  WHITE TAMMIE K ,  TURNER SEAN C ,  DRIZIN IRENE ,  GOMTSYAN ARTHUR R ,  DIDOMENICO STANLEY JR

IPC: A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12 ,  C07D521/00 ,  C07D417/02 ,  A61K31/502 ,  C07D403/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

公开(公告)号：CA2447671A1

公开(公告)日：2002-11-28

申请号：CA2447671

申请日：2002-05-14

Applicant: ABBOTT LAB

Inventor： DIDOMENICO STANLEY ,  GOMTSYAN ARTHUR R ,  ZHENG GUO ZHU ,  STEWART ANDREW O ,  PERNER RICHARD J ,  BAYBURT EROL K ,  KOENIG JOHN R ,  LARSON DANIEL P ,  LEE CHIH-HUNG

IPC: A61K31/194 ,  A61K31/275 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/505 ,  A61P13/00 ,  A61P13/02 ,  A61P13/10 ,  A61P21/00 ,  A61P25/04 ,  A61P43/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/74 ,  C07C233/76 ,  C07C233/79 ,  C07C251/48 ,  C07C251/52 ,  C07C255/60 ,  C07C311/51 ,  C07C321/24 ,  C07D207/06 ,  C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D309/32 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/40 ,  C07D333/42 ,  C07D333/68 ,  C07D333/72 ,  A61K31/166 ,  A61K31/18 ,  C07C233/78 ,  C07C255/54 ,  C07C261/04 ,  C07C323/32 ,  C07D295/12

Abstract: Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.

公开(公告)号：CY1108713T1

公开(公告)日：2014-04-09

申请号：CY091100044

申请日：2009-01-14

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: Ηπαρούσαεφεύρεσηφέρειστοπροσκήνιοκαινοφανείςενώσειςγενικούτύπου (I), ήφαρμακευτικώςαποδεκτόάλαςή πρόδρομοφάρμακοαυτών (σταοποίαΧ1-Χ5, R5- R8b, Ζ1- Ζ2 καιΑr1 ορίζονταιστοπαρόν), μίαμέθοδοαναστολήςτουυποδοχέα VR1 σεθηλαστικάκάνονταςχρήσηαυτώντωνενώσεων, μίαμέθοδοελέγχουτουάλγουςσεθηλαστικά, φαρμακευτικέςσυνθέσειςπουπεριλαμβάνουνεκείνεςτιςενώσεις, καθώςκαιμίαδιεργασίαπαρασκευήςτωνενλόγωενώσεων.

公开(公告)号：NZ571706A

公开(公告)日：2012-06-29

申请号：NZ57170607

申请日：2007-04-12

Applicant: ABBOTT LAB

Inventor： BROWN BRIAN S ,  KOENIG JOHN R ,  GOMTSYAN ARTHUR R ,  LEE CHIH-HUNG

IPC: A61K31/416 ,  A61K31/352 ,  C07D231/56 ,  C07D493/00

Abstract: The disclosure relates to spiro-chroman compounds of formula (I), wherein the variables X1, X2, Y, R1a, R1, R2a, R2b, A1, A2, A3, and A4 are as defined in the specification. These compounds have vanilloid receptor subtype I (VR1) inhibiting activity and are suitable for use in treating pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.

公开(公告)号：AU2011244937A1

公开(公告)日：2011-11-24

申请号：AU2011244937

申请日：2011-11-02

Applicant: ABBOTT LAB

Inventor： ARTHUR GOMTSYAN ,  CHIH-HUNG LEE ,  GILLES CHAMBOURNIER ,  KOENIG JOHN R ,  KIRILL LUKIN ,  ROBERT LEANNA M ,  MARGARET HSU ,  ROBERT SCHMIDT ,  CINK RUSSEL D

IPC: A61P13/10 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR Abstract The present invention discloses novel compounds of general formula (I), or a s pharmaceutically acceptable salt or prodrug thereof (in which X, - X5 , R5 - R8b, ZI - Z2 and Ari are defined herein), a method for inhibiting the VRI receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：SI2017265T1

公开(公告)日：2011-09-30

申请号：SI200431715

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA ROBERT M ,  CINK RUSSEL D

IPC: C07D217/00 ,  A61K31/416 ,  A61K31/472 ,  A61P13/00 ,  A61P13/10 ,  C07C211/00 ,  C07D217/02 ,  C07D231/00 ,  C07D231/56 ,  C07D401/00 ,  C07D401/12 ,  C07D403/00 ,  C07D403/12

公开(公告)号：MY144307A

公开(公告)日：2011-08-29

申请号：MYPI20084102

申请日：2007-04-12

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR R ,  KOENIG JOHN R ,  CHIH-HUNG LEE ,  BROWN BRIAN S

IPC: A61K31/416

Abstract: ANTAGONISTS OF THE VANILLOED RECEPTOR SUBTYPE I (VRI) AND USES THEIREOF THE PRESENT INVENTION IS DIRECTED TO COMPOUNDS OF FORMULA (1), WHEREIN VARIABLES X', X', Y, 5 R", R IB, R?I, R2B , AL, A2,A3, AND A4ARE AS DEFINED IN THE DESCRIPTION, AND MEDIODS OF USE TO TREAT PAIN, RIEUROPADIIC PAIN, ALLODYNIA, PAIN ASSOCIATED WITH FIFFLAINMATION OR AN INFLAIRMIATORY DISEASE, INFLARNMATORY HYPERALGESIA, BLADDER OVERACTIVITY, AND URINARY INCONTINENCE. COR 1 B AL R 1 BR A3

公开(公告)号：BRPI0710507A2

公开(公告)日：2011-08-16

申请号：BRPI0710507

申请日：2007-04-12

Applicant: ABBOTT LAB

Inventor： BROWN BRIAN S ,  KOENIG JOHN R ,  GOMTSYAN ARTHUR R ,  LEE CHIH-HUNG

IPC: A61K31/416 ,  A61K31/352 ,  C07D231/56 ,  C07D493/00

Abstract: The present invention is directed to compounds of formula (I) wherein variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, and A4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.