公开(公告)号：CA2343259A1

公开(公告)日：2001-10-06

申请号：CA2343259

申请日：2001-04-05

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JORG ,  KESSEL KNUT ,  SCHERR GUNTER ,  BOGENSTATTER THOMAS

IPC: A61K9/20 ,  A61K31/198 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02 ,  A61P21/00 ,  C08K5/29 ,  C08L101/00

Abstract: a) a mixture which comprises at least one thermoplastic, physiologically tolerated, water-soluble or water-swellable polymeric binder and creatine, and contains 1 to 20 mol of water per mol of creatine is prepared, b) the mixture is plasticated at or above the softening point of the polymeric binder, preferably with at least partial evaporation of the water, c) the plasticated mixture is shaped to dosage forms and cooled.

公开(公告)号：ES2151150T3

公开(公告)日：2000-12-16

申请号：ES96907414

申请日：1996-03-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：AU724502B2

公开(公告)日：2000-09-21

申请号：AU2770097

申请日：1997-04-24

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KOLTER KARL ,  SCHMITT ANGELIKA

IPC: C08J3/12 ,  A61K8/81 ,  A61K9/28 ,  A61K47/32 ,  A61Q1/12 ,  C08J3/03 ,  C08L31/00 ,  C08L33/08 ,  C08L33/10

Abstract: Polymer powders redispersible in aqueous solution, their use in cosmetic, pharmaceutical or crop protection formulations and a process for preparing polymer powders redispersible in aqueous solution comprising copolymers carrying free acid or base groups and, if appropriate, auxiliaries, which comprises adjusting the pH of the dispersion prior to drying by the addition of at least one buffer system to a pH of from 2.0 to 6.5 in the case of copolymers carrying free acid groups or a pH of from pH 7.5 to 12 in the case of copolymers carrying free base groups.

公开(公告)号：AU3930399A

公开(公告)日：1999-12-06

申请号：AU3930399

申请日：1999-05-04

Applicant: BASF AG

Inventor： HEGER ROBERT ,  AUWETER HELMUT ,  PFLUGER PETER ,  BREITENBACH JORG ,  BINDER RUDOLF ,  ZEIDLER JURGEN ,  BERNDL GUNTHER

IPC: A61K9/16 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K47/14 ,  A61K47/36 ,  A61P37/06 ,  A61K9/00

公开(公告)号：NZ298774A

公开(公告)日：1999-07-29

申请号：NZ29877495

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：BR9610234A

公开(公告)日：1999-06-29

申请号：BR9610234

申请日：1996-08-21

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/20

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

公开(公告)号：CA2312917A1

公开(公告)日：1999-06-17

申请号：CA2312917

申请日：1998-12-09

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  MAIER WERNER ,  TRAPP BURKHARD ,  JOTTER KARL LUDWIG ,  ROSENBERG JOERG ,  KRULL HARALD ,  FARWERCK KARL-PETER ,  LANGE ARMIN ,  KLEINKE ANDREAS ,  JOCHUM ALFONS

IPC: A61K9/16 ,  B01J2/20 ,  B29B9/06 ,  B30B9/28 ,  B30B11/22 ,  C05G3/00

Abstract: The invention relates to an extrusion device, particularly an extrusion device for thermoplastic or dough-like masses or highly tenacious melts, and to the use of said device. The extrusion device has a housing (11), at least one conveyor worm (12) arranged in a housing and an outlet (20) disposed on the front face of the housing (11) close to the end of each conveyor screw which is furthest away from the drive end. At least one stripping member (21) is arranged in between the end (14) of each conveyor screw (12) furthest away from the drive end and the outlet (20). The device is particularly suitable for producing granulates, preferably those containing active substances.

公开(公告)号：ES2129800T3

公开(公告)日：1999-06-16

申请号：ES95904453

申请日：1994-12-10

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  GRABOWSKI SVEN ,  SANNER AXEL

IPC: C07C407/00 ,  C01B15/037 ,  C07C409/00 ,  C07C409/24 ,  C07C409/26 ,  C08K3/20 ,  C08K5/14 ,  C08L5/00 ,  C08L5/16 ,  C08L39/00

公开(公告)号：IN182500B

公开(公告)日：1999-04-17

申请号：IN1824MA1996

申请日：1996-10-16

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  HARTL AXEL PAUL ,  HOFMANN JURGEN ,  ROSENBERG JOERG ,  SCHIEBL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/00

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：SK104397A3

公开(公告)日：1998-04-08

申请号：SK104397

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.