公开(公告)号：DE59808550D1

公开(公告)日：2003-07-03

申请号：DE59808550

申请日：1998-12-09

Applicant: BASF AG

Inventor： KLEINKE ANDREAS ,  FARWERCK KARL-PETER ,  JOCHUM ALFONS ,  LANGE ARMIN ,  KRULL HARALD ,  ROSENBERG JOERG ,  MAIER WERNER ,  JOTTER LUDWIG ,  TRAPP BURKHARD ,  BREITENBACH JOERG

IPC: A61K9/16 ,  B01J2/20 ,  B29B9/06 ,  B30B9/28 ,  B30B11/22 ,  C05G3/00

公开(公告)号：AT239452T

公开(公告)日：2003-05-15

申请号：AT97942022

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.

公开(公告)号：ES2180738T3

公开(公告)日：2003-02-16

申请号：ES96903958

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：DK0857062T3

公开(公告)日：2002-07-15

申请号：DK96937214

申请日：1996-10-23

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  AXEL PAUL HAERTL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  HANS DIETER ZETTLER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：AT209913T

公开(公告)日：2001-12-15

申请号：AT94917601

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  MUELLER WINFRIED ,  ROSENBERG JOERG ,  BINDER RUDOLF ,  SANNER AXEL

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：AT204162T

公开(公告)日：2001-09-15

申请号：AT96907439

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：DE19929361A1

公开(公告)日：2001-01-04

申请号：DE19929361

申请日：1999-06-25

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  ROSENBERG JOERG

IPC: A61K9/14 ,  A61K9/20 ,  A61K31/4422 ,  A61K9/26

Abstract: The invention relates to preparations in the form of solid solutions of pharmaceutical active ingredients in an auxiliary agent matrix. The auxiliary agent matrix contains a homopolymer or copolymer of N-vinyl pyrrolidone as the polymer constituent and a surface-active surface which is liquid at 20 DEG C or has a drop point of between 20 DEG C and 50 DEG C.

公开(公告)号：PL178963B1

公开(公告)日：2000-07-31

申请号：PL32093695

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：SK26099A3

公开(公告)日：2000-03-13

申请号：SK26099

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.

公开(公告)号：BR9800871A

公开(公告)日：1999-12-07

申请号：BR9800871

申请日：1998-03-11

Applicant: BASF AG

Inventor： ZEIDLER J RGEN ,  ROSENBERG JOERG ,  BREITENBACH J RG ,  KLEINKE ANDREAS ,  MAIER WERNER

IPC: A61J3/10 ,  A61K9/20 ,  A61K47/26 ,  A61K47/30 ,  B30B11/16 ,  A61K9/32