公开(公告)号：EP2362947A4

公开(公告)日：2012-10-24

申请号：EP09818087

申请日：2009-09-25

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： ZACCARIN DENIS ,  LUNDQUIST PAUL ,  ZHAO PEIQIAN ,  ZHONG FRANK ,  TURNER STEPHEN ,  HUANG YANQIAO ,  MONADGEMI PEZHMAN ,  SAXENA RAVI ,  GROT ANNETTE ,  RULISON AARON

IPC: G02B6/12 ,  G01N21/00

CPC classification number: G01N21/6452 ,  B05D1/005 ,  C23C16/50 ,  G01N21/253 ,  G02B6/12002 ,  G02B6/131 ,  G02B6/132 ,  G02B6/136 ,  G02B2006/12035 ,  G02B2006/12061 ,  G02B2006/12104 ,  G02B2006/12164 ,  G02B2006/12197

公开(公告)号：EP1963530A4

公开(公告)日：2009-08-05

申请号：EP06848008

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C12N11/14

CPC classification number: C12Q1/6837 ,  C07K2319/23 ,  C12N9/1252 ,  C12Q1/6844 ,  C12Q2521/101 ,  C12Q2565/531

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：CA2642258C

公开(公告)日：2015-10-06

申请号：CA2642258

申请日：2007-02-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  ZACCARIN DENIS ,  LACROIX YVES ,  MAXHAM MARK ,  FOQUET MATHIEU ,  TURNER STEPHEN

IPC: G01J1/02 ,  C12Q1/68 ,  C40B30/00 ,  G01J1/42 ,  G01J3/28 ,  G01J3/443

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

公开(公告)号：CA2633476C

公开(公告)日：2015-04-21

申请号：CA2633476

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12N9/12 ,  C12N9/22 ,  C12N11/00 ,  C12P19/34 ,  C12Q1/68

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：AU2013240166A1

公开(公告)日：2014-10-30

申请号：AU2013240166

申请日：2013-03-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  CLARK TYSON A

IPC: C12Q1/68 ,  G01N33/48

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, a basic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

公开(公告)号：AU2007289057C1

公开(公告)日：2014-01-16

申请号：AU2007289057

申请日：2007-08-31

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN

IPC: F21V9/16

Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

公开(公告)号：CA2867489A1

公开(公告)日：2013-10-03

申请号：CA2867489

申请日：2013-03-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  CLARK TYSON A

IPC: C12Q1/68 ,  G01N33/48

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, a basic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

公开(公告)号：AU2012216605A1

公开(公告)日：2012-09-20

申请号：AU2012216605

申请日：2012-09-03

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： RANK DAVID R ,  WEGENER JEFFERY ,  KORLACH JONAS ,  ROITMAN DANIEL ,  XU YUE ,  LYLE JOHN ,  TURNER STEPHEN ,  PELUSO PAUL ,  OTTO GEOFF

IPC: C12N11/00 ,  C40B40/04

Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.

公开(公告)号：DK2002019T3

公开(公告)日：2012-06-18

申请号：DK07754529

申请日：2007-03-29

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： RANK DAVID R ,  WEGENER JEFFERY ,  ROITMAN DANIEL ,  XU YUE ,  LYLE JOHN ,  TURNER STEPHEN ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFF ,  CICERO RONALD L

IPC: C12N11/00 ,  C40B40/04

公开(公告)号：CA2616439C

公开(公告)日：2012-03-20

申请号：CA2616439

申请日：2006-08-10

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN ,  ZACCARIN DENIS

IPC: G01D5/28 ,  C40B20/08 ,  C40B30/10 ,  G01N21/75 ,  G01N33/58 ,  G02B26/08 ,  G02B27/10

Abstract: Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical signal is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.