公开(公告)号：CA2647597A1

公开(公告)日：2007-12-06

申请号：CA2647597

申请日：2007-05-30

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  PATEL MEENA V ,  FROST JENNIFER M ,  DART MICHAEL J ,  TIETJE KARIN ROSEMARIE ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  NELSON DEREK W ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  GALLAGHER MEGAN E

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：CA2378936A1

公开(公告)日：2001-02-08

申请号：CA2378936

申请日：2000-08-02

Applicant: ABBOTT LAB

Inventor： PEREZ-MEDRANO ARTURO ,  HOLLADAY MARK W ,  ZHANG HENRY Q ,  CARROLL WILLIAM A ,  HUANG PEGGY P ,  LYNCH JOHN K ,  GREGG ROBERT J ,  GOPALAKRISHNAN MURALI ,  KINCAID JOHN F ,  ALTENBACH ROBERT J ,  KORT MICHAEL E ,  KYM PHILIP R ,  BAI HAO ,  BRIONI JORGE D

IPC: C07D249/18 ,  A61K31/166 ,  A61K31/17 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/47 ,  A61P1/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/10 ,  A61P17/14 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C275/54 ,  C07C279/22 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07C335/26 ,  C07D209/08 ,  C07D213/74 ,  C07D213/75 ,  C07D215/38 ,  C07D233/02 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  A61K31/155 ,  C07C279/30

Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.