公开(公告)号：CA1155859A

公开(公告)日：1983-10-25

申请号：CA360589

申请日：1980-09-19

Applicant: BASF AG

Inventor： WIERSDORFF WALTER-WIELANT ,  GEISS KARL-HEINZ ,  WEIFENBACH HARALD ,  WORSTMANN WOLFGANG ,  LENKE DIETER ,  KRETZSCHMAR ROLF

IPC: A61K31/27 ,  A61K31/325 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P25/20 ,  C07C45/62 ,  C07C45/69 ,  C07C45/75 ,  C07C45/79 ,  C07C45/81 ,  C07C49/21 ,  C07C49/337 ,  C07C49/345 ,  C07C49/543 ,  C07C49/553 ,  C07C49/573 ,  C07C67/00 ,  C07C68/02 ,  C07C68/06 ,  C07C69/96 ,  C07C239/00 ,  C07C271/06 ,  C07C271/08 ,  C07C313/00 ,  C07C319/20 ,  C07C323/43 ,  C07D307/14 ,  C07D307/22 ,  C07D307/52 ,  C07D309/04 ,  C07D309/14 ,  C07D317/28 ,  C07D319/06 ,  C07D333/20 ,  C07C125/065 ,  C07D333/24 ,  C07D307/54

Abstract: Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their praparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.

公开(公告)号：AU532982B2

公开(公告)日：1983-10-20

申请号：AU6320480

申请日：1980-10-13

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  PHILIPSBORN GERDA VON ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：ZA8206832B

公开(公告)日：1983-08-31

申请号：ZA8206832

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER WIELANT ,  HEGE HANS GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C217/36 ,  C07C225/22 ,  C07C323/25 ,  C07D207/06 ,  C07D211/44 ,  C07D211/52 ,  C07D295/08 ,  A61K ,  C07C

公开(公告)号：ZA8206453B

公开(公告)日：1983-08-31

申请号：ZA8206453

申请日：1982-09-03

Applicant: BASF AG

Inventor： SCHLECKER RAINER ,  LUDWIG FRIEDRICH ,  LENKE DIETER

IPC: A61K31/425 ,  A61K31/428 ,  A61P37/08 ,  C07D277/60 ,  C07D277/84 ,  A61K ,  C07D

CPC classification number: C07D277/60 ,  C07D277/84

公开(公告)号：NO147877B

公开(公告)日：1983-03-21

申请号：NO794316

申请日：1979-12-28

Applicant: BASF AG

Inventor： TREIBER HANS JOERG ,  LENKE DIETER ,  WORSTMANN WOLFGANG

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：HU180135B

公开(公告)日：1983-02-28

申请号：HU116080

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：AU527311B2

公开(公告)日：1983-02-24

申请号：AU5284979

申请日：1979-11-15

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS DIETER

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12

公开(公告)号：CA1135705A

公开(公告)日：1982-11-16

申请号：CA332072

申请日：1979-07-18

Applicant: BASF AG

Inventor： BLIESENER JENS-UWE ,  GEISS KARL-HEINZ ,  LENKE DIETER ,  MUELLER CLAUS D

IPC: A61K31/40 ,  C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12

Abstract: Disclosed are compound of the formula 1 wherein R1 is alkyl of 2 to 5 carbon atom, alkyl, benzyl, furylmethyl wherein the furan ring may be substituted by bromine or thienylmethyl wherein the thiophene ring may he monosubstituted by a methyl and R2 is hydrogen or R1 and R2 together with the nitrogen form a pyrrolidine ring R3 is hydrogen, methyl or ethyl R4 and R5 are hydrogen ox R4 is methyl or ethyl in the .alpha.-position of the pyrrole ring and R5 in methyl, ethyl or Npropyl in the .alpha.-position of the pyrrole ring X is oxygen, sulfur or and Ar in phenyl that may be substituted by chlorine, and their therapeutically useful ammonium salts, alkali metal salts or acid addition salts, which compounds and salts thereof exhibit valuable pharmacological properties, their preperation, therapeutic agents containing these products, and their use as drugs.

公开(公告)号：FI823217A0

公开(公告)日：1982-09-17

申请号：FI823217

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MYLLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GYNTHER ,  MYLLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：ZA8104902B

公开(公告)日：1982-08-25

申请号：ZA8104902

申请日：1981-07-17

Applicant: BASF AG

Inventor： EILINGSFELD HEINZ ,  NEUMANN PETER ,  SEYBOLD GUENTHER ,  LENKE DIETER ,  FRIEDRICH LUDWIG

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P37/08 ,  C07D277/44 ,  C07D277/46 ,  A61K ,  C07D

CPC classification number: C07D277/46