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公开(公告)号:AU4709479A
公开(公告)日:1979-11-22
申请号:AU4709479
申请日:1979-05-16
Applicant: DEGUSSA
Inventor: ENGEL JURGEN , KLEEMANN AXEL , POSSELT KLAUS , STROMAN FRITZ , THIEMER KLAUS
IPC: A61K31/135 , A61K20060101 , A61K31/13 , A61K31/137 , A61K31/43 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P29/00 , C07C20060101 , C07C67/00 , C07C213/00 , C07C213/02 , C07C213/08 , C07C215/30 , C07C215/60 , C07C221/00 , C07C225/06 , C07C225/10 , C07C225/14 , C07C97/10
Abstract: There are prepared compounds of the formula: wherein X is the group >C=O or >CH(OH), Y is the group R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is the adamantyl group or a saturated or single unsaturated C3 to C16 cycloalkyl group where the C3 to C16 cycloalkyl group can be substituted by a C1-C4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.
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公开(公告)号:DD137926A5
公开(公告)日:1979-10-03
申请号:DD20679378
申请日:1978-07-18
Applicant: DEGUSSA
Inventor: KLEEMANN AXEL , KLENK HERBERT , OFFERMANN HERIBERT , SCHERBERICH PAUL , SCHWARZE WERNER
IPC: A01N25/00 , A01P3/00 , A01P13/00 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/08 , C07C235/72 , C07D307/54 , C07C103/34
Abstract: Compounds are prepared of the formula (I) where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl group or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formula R-CO-CN (II) where R is as defined above with either (a) a tertiary alcohol of the formula HO-R'(III) in which R' is as defined above, or preferably (b) an alkene of the formula (IV) where R1 and R2 are the same or different and are hydrogen or an alkyl group and wherein R3 and R4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.
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公开(公告)号:DD133331A5
公开(公告)日:1978-12-27
申请号:DD20255577
申请日:1977-12-12
Applicant: DEGUSSA
Inventor: KLEEMANN AXEL , KLINGLER KARL H , VON SCHLICHTEGROLL ANSGAR , STROMAN FRITZ , THIEMER KLAUS , WESTERMANN ERIK
IPC: A61K31/52 , A61K31/522 , A61P9/00 , C07D473/08
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公开(公告)号:NO781159A
公开(公告)日:1978-10-05
申请号:NO781159
申请日:1978-04-03
Applicant: DEGUSSA
Inventor: KLEEMANN AXEL , JAKOVLEV VLADIMIR , THIEMER KLAUS , ENGEL JUERGEN
IPC: C07D295/08 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/20 , C07D213/74 , C07D213/80 , C07D295/033 , C07D295/088 , C07D295/092 , C07D295/135 , C07D303/24 , C07D307/68 , C07D333/38 , C07D
CPC classification number: C07D213/74 , C07D213/80 , C07D295/088 , C07D295/135 , C07D303/24
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公开(公告)号:NO780100A
公开(公告)日:1978-07-13
申请号:NO780100
申请日:1978-01-11
Applicant: DEGUSSA
Inventor: KLEEMANN AXEL , KIEL REINHOLD , NUBERT INGOMAR
IPC: C07D333/14 , A61K31/382 , C07D333/16 , C07D333/20 , C07D
CPC classification number: C07D333/16 , C07D333/20
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公开(公告)号:CA876142A
公开(公告)日:1971-07-20
申请号:CA876142D
Applicant: DEGUSSA
Inventor: WEIBERG OTTO , KLEEMANN AXEL , SCHREYER GERD , WEIGERT WOLFGANG
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公开(公告)号:FI73976C
公开(公告)日:1987-12-10
申请号:FI822397
申请日:1982-07-06
Applicant: DEGUSSA
Inventor: BETHGE HORST , KLEEMANN AXEL , MARTENS JUERGEN
IPC: A61K31/195 , C07B57/00 , C07C20060101 , C07C67/00 , C07C319/28 , C07C313/00 , C07C323/58 , C07C149/243 , C07C148/04 , C07C91/16
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公开(公告)号:FI73663B
公开(公告)日:1987-07-31
申请号:FI822399
申请日:1982-07-06
Applicant: DEGUSSA
Inventor: BETHGE HORST , KLEEMANN AXEL , MARTENS JUERGEN
IPC: C07B57/00 , C07B31/00 , C07C20060101 , C07C67/00 , C07C213/00 , C07C213/10 , C07C215/30 , C07C313/00 , C07C323/58 , C07C91/16 , C07C89/04 , C07C149/243
Abstract: There is described the resolution of the racemate (1RS,2SR)-2-amino-1-phenyl-propan-1-ol. It is carried out by means of the optical isomers of S-(carboxymethyl)-cysteine.
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公开(公告)号:CA1223886A
公开(公告)日:1987-07-07
申请号:CA449824
申请日:1984-03-16
Applicant: DEGUSSA
Inventor: KARRENBAUER MICHAEL , KLEEMANN AXEL , LUESSLING THEODOR , SCHAEFER FRITZ
IPC: C07C319/24 , C07C67/00 , C07C313/00 , C07C323/58 , C07C149/243
Abstract: D,L-homocystine is produced by mixing an aqueous solution of the disodium salt of D,L-homocysteine having a concentration of between 0.4 and 1.6 moles per litre and an initial pH of between 7.0 and 8.0 with at least the equivalent amount of an aqueous hydrogen peroxide solution and on completed oxidation the pH is adjusted to approximately 5.3. The hydrogen peroxide solution can be applied in a concentration of between 20 and 60 percent by weight.
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公开(公告)号:FI72314C
公开(公告)日:1987-05-11
申请号:FI824337
申请日:1982-12-16
Applicant: DEGUSSA
Inventor: BETHGE HORST , KLEEMANN AXEL , MARTENS JUERGEN
IPC: C07B55/00 , C07B31/00 , C07C20060101 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/58 , C07C149/243 , C07C148/00
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