公开(公告)号：CA2850693C

公开(公告)日：2016-04-19

申请号：CA2850693

申请日：2012-11-12

Applicant: HOFFMANN LA ROCHE

Inventor： PETRICH WOLFGANG ,  HORN CARINA ,  STEINKE NELLI ,  RINGEMANN CHRISTIAN ,  VON KETTELER ALEXA

IPC: A61B5/145 ,  G01N21/64 ,  G01N35/00

Abstract: An analytical apparatus (130) for detecting at least one analyte in a sample (126), in particular for detecting blood glucose, is proposed, - where the analytical apparatus (130) is equipped to carry out at least one analyte measurement, where in the analyte measurement at least a property changeable by presence of the analyte at least of a test chemical (119) of a test element (110) is recorded, in particular an electrical and/or optical property, and - where the analytical apparatus (130) is furthermore equipped to carry out at least a quality measurement on the test chemical (119), where in the quality measurement at least an intrinsic luminescence of the test chemical (119) is recorded and from the intrinsic luminescence a conclusion is drawn on a quality of the test chemical (119), in particular a degradation.

公开(公告)号：PL2513648T3

公开(公告)日：2015-11-30

申请号：PL10796365

申请日：2010-12-15

Applicant: HOFFMANN LA ROCHE

Inventor： HORN CARINA ,  HEINDL DIETER ,  HAAR HANS-PETER ,  STEINKE NELLI

IPC: G01N33/50 ,  C12Q1/54

公开(公告)号：CA2896152A1

公开(公告)日：2014-06-26

申请号：CA2896152

申请日：2013-12-19

Applicant: HOFFMANN LA ROCHE

Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

公开(公告)号：DK2364989T3

公开(公告)日：2014-06-10

申请号：DK11167476

申请日：2006-07-28

Applicant: HOFFMANN LA ROCHE

Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

公开(公告)号：DK2364988T3

公开(公告)日：2014-05-26

申请号：DK11167471

申请日：2006-07-28

Applicant: HOFFMANN LA ROCHE

Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

公开(公告)号：CA2854959A1

公开(公告)日：2013-06-27

申请号：CA2854959

申请日：2012-12-20

Applicant: HOFFMANN LA ROCHE

Inventor： HORN CARINA ,  UNKRIG VOLKER

IPC: C12Q1/54 ,  A61B5/145 ,  G01N33/52

Abstract: The invention relates to a method, to a test element (50), and to a device (190) for determining at least one concentration of at least one analyte in a sample (110), in particular for detecting at least one metabolite in a sample (110) of a bodily fluid, wherein at least one test element (50) having at least one test chemistry (102) is used, wherein at least one reaction of the test chemistry (102) with the analyte is detected. The invention further relates to at least one marker (104, 104'), wherein the marker (104, 104') is different from the analyte (117), wherein at least one diffusion of the marker (104, 104') in the sample (110) or at least one component of the sample (110) is detected. At least one piece of correction information is produced from the diffusion of the marker (104, 104'), wherein the concentration of the analyte is determined from the reaction of the test chemistry (102) with the analyte while taking into account the correction information.

公开(公告)号：AU2012203453B2

公开(公告)日：2012-12-06

申请号：AU2012203453

申请日：2012-06-13

Applicant: HOFFMANN LA ROCHE

Inventor： HORN CARINA ,  HOENES JOACHIM ,  HEINDL DIETER ,  GAESSLER-DIETSCHE CLAUDIA

IPC: C12N9/96 ,  C12N9/06 ,  C12Q1/32

Abstract: Stabilisation of dehydrogenases with stable coenzymes Abstract The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. Furthermore, the present invention relates to an enzyme stabilized using a stable coenzyme and to the use thereof in test elements for detecting analytes. C:\NRPortbI\DCC\GRS\4394283 I DOC - 13/6/12

公开(公告)号：MX2012006706A

公开(公告)日：2012-07-03

申请号：MX2012006706

申请日：2010-12-15

Applicant: HOFFMANN LA ROCHE

Inventor： HAAR HANS-PETER ,  HEINDL DIETER ,  HORN CARINA ,  STEINKE NELLI

IPC: G01N33/50 ,  C12Q1/54

Abstract: La presente invención se refiere al elemento de diagnóstico para determinar al menos un analito así como un dispositivo de medición analítico que comprende tal elemento de diagnóstico. La invención se refiere adicionalmente a un método para determinar un analito, un método para corregir una señal generada por un analito así como un método para revisar los ópticos de detección de un dispositivo de medición analítica utilizando el elemento de diagnóstico. La invención se refiere finalmente a un sistema para la liberación controlada de un reactivo, y al uso de tal sistema como un elemento de circuito.

公开(公告)号：AU2011200465B2

公开(公告)日：2012-02-09

申请号：AU2011200465

申请日：2011-02-04

Applicant: HOFFMANN LA ROCHE

Inventor： HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA ,  HEINDL DIETER ,  HOENES JOACHIM

IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

Abstract: C:\NRPoRtblCCIGRS\342 044 I DOC-3/02/20l - 46 Stable NAD/NADH derivatives Abstract 5 The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (1), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.

公开(公告)号：CA2585041C

公开(公告)日：2011-12-13

申请号：CA2585041

申请日：2005-10-25

Applicant: HOFFMANN LA ROCHE

Inventor： HORN CARINA

IPC: G01N21/64 ,  G01N21/86 ,  G01N33/542

Abstract: The present invention concerns a system for the luminescence detection of an analyte in a liquid sample where the system comprises a support on which an analyte-specific substance and a reference substance are located. In addition the invention concerns a method for detecting an analyte in a liquid sample in which the said system is used. In addition to detecting an analyte, the system according to the invention is also suitable for determining the amount of sample, the amount of analyte and/or the operational readiness of the support for a detection.