公开(公告)号：MX2013015147A

公开(公告)日：2014-03-27

申请号：MX2013015147

申请日：2012-07-03

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM ,  TANOURY GERALD J ,  JUNG YOUNG CHUN ,  MAGDZIAK DEREK ,  KLINE BRILLIE J ,  JURCIK VÁCLAV ,  OLMO BEATRIZ DOMINGUEZ

IPC: C07D471/04

Abstract: La presente invención se refiere a procesos y productos intermediarios para la preparación de compuestos útiles como inhibidores de cinasas Janus (JAK).

公开(公告)号：SG175800A1

公开(公告)日：2011-12-29

申请号：SG2011078581

申请日：2010-04-27

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E ,  LOOKER ADAM ,  JURKAUSKAS VALDAS

Abstract: The invention relates to compounds and processes u useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

公开(公告)号：AU2005223767B2

公开(公告)日：2011-12-01

申请号：AU2005223767

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： MINZHANG CHEN ,  JONES ANDREW D ,  TANOURY GERALD J ,  SNOONIAN JOHN R ,  NYCE PHILIP L ,  MARTIN TRUDEAU ,  GUERIN DAVID J

IPC: C07B43/04 ,  C07B57/00 ,  C07D405/12

Abstract: The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.

公开(公告)号：SG170729A1

公开(公告)日：2011-05-30

申请号：SG2011018868

申请日：2007-03-14

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  JUNG YOUNG CHUN ,  FORSLUND RAYMOND E

Abstract: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula (1) wherein the variables R1R'1 and R2 are defined herein and the compound of Formula (1) has an enantiomeric excess (ee) of 55% or greater. No suitable figure

公开(公告)号：SI1934179T1

公开(公告)日：2010-08-31

申请号：SI200630710

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E

IPC: C07D209/00

公开(公告)号：DK1934179T3

公开(公告)日：2010-08-09

申请号：DK06813568

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E

IPC: C07D209/52

公开(公告)号：SG150546A1

公开(公告)日：2009-03-30

申请号：SG2009013061

申请日：2005-03-11

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  JONES ANDREW D ,  NYCE PHILIP L ,  TRUDEAU MARTIN ,  GUERIN DAVID J ,  SNOONIAN JOHN R

IPC: C07B43/04 ,  C07B57/00 ,  C07D405/12

Abstract: The invention relates to a process of producing a compound of comprising purifying a mixture of wherein R 8 is a protecting group, and purifying includes chromatographing, selectively crystallizing, or dynamically crystallizing the mixture.

公开(公告)号：CA2619659A1

公开(公告)日：2007-02-22

申请号：CA2619659

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E

IPC: C07D209/52 ,  A61K31/403

Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

公开(公告)号：AU2006279357A1

公开(公告)日：2007-02-22

申请号：AU2006279357

申请日：2006-08-18

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E

IPC: C07D209/52

Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

公开(公告)号：DK3421468T3

公开(公告)日：2021-01-11

申请号：DK18164040

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083