公开(公告)号：DE19843904A1

公开(公告)日：2000-03-30

申请号：DE19843904

申请日：1998-09-24

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BERNDL GUNTHER ,  MEFFERT HELMUT

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/32 ,  A61K9/42

Abstract: A solid dosage form contains a copolymer of an N-vinyl-lactam, methyl methacrylate, an ester or acid derivative monomer and optionally an acid monomer, as polymeric binder. A solid dosage form comprises least one polymeric binder, at least one active agent (A) and optionally conventional additives, where the binder is a copolymer of: (a) at least one N-vinyl-lactam of formula (I) (15-83 wt. %); (b) methyl methacrylate (15-83 wt. %); (c) at least one monomer (2-70 wt. %) selected from vinyl esters of 1-22C aliphatic carboxylic acids, esters of 3-8C alpha , beta -ethylenically unsaturated mono- or dicarboxylic acids with 1-8C alkanols, 1-4C diols or di-(1-4C alkyl)-amino-(1-4C) alkanols and amides, nitriles or cyclic anhydrides of these acids; and (d) at least one alpha , beta -ethylenically unsaturated acid (0-9.9 wt. %) selected from 3-8C alpha , beta -ethylenically unsaturated mono- or dicarboxylic acids, their non-cyclic anhydrides, hemi-esters of the dicarboxylic acids and alpha , beta -ethylenically unsaturated sulfonic acids (including salts or quaternized derivatives). n = 1-3. An Independent claim is included for the preparation of the dosage form, by mixing the components (directly or after preliminary melting) and shaping the obtained plastic mixture into the required dosage form.

公开(公告)号：NO20000486D0

公开(公告)日：2000-01-31

申请号：NO20000486

申请日：2000-01-31

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG

IPC: A23K40/10 ,  A23K40/20 ,  A23K50/80 ,  A23K

Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

公开(公告)号：CA2298659A1

公开(公告)日：1999-02-11

申请号：CA2298659

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JURGEN ,  ROSENBERG JORG ,  BREITENBACH JORG ,  BERNDL GUNTHER ,  VOLLGRAF CHRISTIANE ,  NEUMANN JORG ,  LIEPOLD BERND

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: The invention relates to a fast-acting analgesic, containing ibuprofen as the active analgesic substance in an auxiliary substance matrix, with a porous structure and a density of greater than 1 - 2.5 g/cm3.

公开(公告)号：CA2298440A1

公开(公告)日：1999-02-11

申请号：CA2298440

申请日：1998-07-21

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG

IPC: A23K40/10 ,  A23K40/20 ,  A23K50/80 ,  A23K1/18 ,  A23K1/00

Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm3 for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

公开(公告)号：AT269060T

公开(公告)日：2004-07-15

申请号：AT99105799

申请日：1999-03-22

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN ,  BERNDL GUNTHER ,  SIMON DIRK ,  SANNER AXEL

IPC: A23L33/00 ,  A61K9/20 ,  A61K9/22 ,  A61K47/32 ,  A61K47/34 ,  C08F279/02 ,  C08L51/04

Abstract: Solid dosage forms containing at least one polymer binder, at least one active ingredient and, where appropriate, conventional additives, wherein a physiologically tolerated, water-swellable graft copolymer or a mixture of graft copolymers is employed as polymeric binder.

公开(公告)号：PT1035841E

公开(公告)日：2002-11-29

申请号：PT98965716

申请日：1998-11-30

Applicant: BASF AG

Inventor： SANNER AXEL ,  KOTHRADE STEPHAN ,  ERNST ANDREAS ,  MEFFERT HELMUT ,  BERNDL GUNTHER

IPC: A61K47/32 ,  A23K20/10 ,  A23K40/10 ,  A23K40/20 ,  A23L27/00 ,  A23L33/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/277 ,  A61K31/421

Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.

公开(公告)号：CA2408915A1

公开(公告)日：2002-11-13

申请号：CA2408915

申请日：2001-05-29

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  HEGER ROBERT ,  WILKE PETER ,  STADLER MICHAEL ,  BREITENBACH JORG ,  ROSENBERG JORG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

公开(公告)号：DE19951617A1

公开(公告)日：2001-05-03

申请号：DE19951617

申请日：1999-10-26

Applicant: BASF AG

Inventor： HEGER ROBERT ,  BREITENBACH JOERG ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K38/00 ,  A61K9/20 ,  A61K9/48 ,  A61K38/13

Abstract: The invention relates to solid pharmaceutical galenic forms comprising an agent in the form of a physical mixture of two different preparations with regard to the physical state of the agent.

公开(公告)号：CA2388614A1

公开(公告)日：2001-05-03

申请号：CA2388614

申请日：2000-10-17

Applicant: BASF AG

Inventor： BINDER RUDOLF ,  BERNDL GUNTHER ,  BREITENBACH JORG ,  HEGER ROBERT

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K9/20

Abstract: The invention relates to solid pharmaceutical galenic forms comprising an agent in the form of a physical mixture of two different preparations with regard to the physical state of the agent.

公开(公告)号：DE19913692A1

公开(公告)日：2000-09-28

申请号：DE19913692

申请日：1999-03-25

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BERNDL GUNTHER ,  LIEPOLD BERND ,  BREITENBACH JOERG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The invention relates to mechanically stable pharmaceutical presentation forms for peroral administration which in addition to one or more active ingredients and at least one thermoplastically mouldable matrix-forming auxiliary contain more than 10 and up to 40 % by weight of a surface-active substance which has an HLB of between 2 and 18 and is liquid at 20 DEG C or has a dropping point at between 20 and 50 DEG C.