公开(公告)号：NO981793L

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JUERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：BG101781A

公开(公告)日：1998-03-31

申请号：BG10178197

申请日：1997-07-17

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JORG ,  ROSENBERG JOERG ,  SANNER ALEX

IPC: A61K9/22 ,  A61K9/20

Abstract: The preparation was produced in the extraction of smelt of atleast one active substance and mixture of from 10 to 90 wt.% watersoluble thermoplastically treatable polymer, from 10 to 90 wt.%hydroxypropylcellulose with low degree of substitution, and from 0to 50 wt.% compared with the total quantity of the preparation,customary pharmacuetically acceptable auxiliary substances.6 claims

公开(公告)号：ZA967170B

公开(公告)日：1998-03-02

申请号：ZA967170

申请日：1996-08-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/20 ,  A61K

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

公开(公告)号：TR9700786T1

公开(公告)日：1998-02-21

申请号：TR9700786

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JOERG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

CPC classification number: A61K9/2054 ,  A61K9/2095

公开(公告)号：TR199700786T1

公开(公告)日：1998-02-21

申请号：TR9700786

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JOERG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：SK77197A3

公开(公告)日：1998-02-04

申请号：SK77197

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JORG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：CA2209943A1

公开(公告)日：1998-01-23

申请号：CA2209943

申请日：1997-07-08

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  ZETTLER HANS DIETER ,  BREITENBACH JOERG ,  SCHIESSL MICHAEL

IPC: A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

Abstract: Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.

公开(公告)号：CA2208495A1

公开(公告)日：1997-12-20

申请号：CA2208495

申请日：1997-06-17

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  DIENER RALPH ,  SIMON DIRK ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  ZEIDLER JUERGEN

IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26 ,  A61K31/185 ,  A61K31/192 ,  A61K31/40 ,  A61K31/405 ,  A61K31/41 ,  A61K31/60

Abstract: A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.

公开(公告)号：PL320936A1

公开(公告)日：1997-11-10

申请号：PL32093695

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：ZA961137B

公开(公告)日：1997-09-16

申请号：ZA961137

申请日：1996-02-13

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  BREITENBACH JOERG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20 ,  A61K

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.