公开(公告)号：KR100367143B1

公开(公告)日：2003-01-09

申请号：KR1020000061923

申请日：2000-10-20

Applicant: 한국화학연구원

Inventor： 오세화 ,  전근 ,  신종일 ,  신승림 ,  김태경 ,  권은경 ,  김진수 ,  박명순

IPC: C09B46/00

Abstract: PURPOSE: Provided are pigment yellow based on quinoxaline which is ecofriendly and has excellent solvent resistance and colorfastness to light, and a method for preparing the same. CONSTITUTION: The pigment yellow based on quinoxaline represented by formula 1 is characterized in that it is prepared using aminoquinoxaline represented by formula 9, as a diazotized compound. In the formulas, R, R1 and R2 are the same or different, and hydrogen, C1-C4 alkyl group, nitro(-NO2), C1-C2 alkoxy group, C1-C18 heterocycle, methyl ester(COOCH3) or halogen group such as chloro or bromo. The pigment yellow is prepared by the steps of (i) diazotizing amino quinoxaline compound represented by formula 9; (ii) dissolving coupler represented by formula 11 into solvent; (iii) mixing two reaction solution obtained from the steps (i) and (ii) at 0-5 deg.C; and (iv) adding base to the solution mixed in the step(iii) to adjust pH to 6-7 with stirring. In the formula 11, R, R1 and R2 are the same as the above.

Abstract translation: 用途：提供基于喹喔啉的颜料黄，其环保并且具有优异的耐溶剂性和耐光不褪色性，及其制备方法。 构成：基于由式1表示的喹喔啉的颜料黄的特征在于其使用由式9表示的氨基喹喔啉作为重氮化化合物制备。 在式中，R，R1和R2相同或不同，并且氢，C1-C4烷基，硝基（-NO2），C1-C2烷氧基，C1-C18杂环，甲酯（COOCH3）或卤素基团 如氯或溴。 通过以下步骤制备颜料黄：（i）使由式9表示的氨基喹喔啉化合物重氮化; （ii）将式11代表的成色剂溶解在溶剂中; （iii）在0-5℃下将步骤（i）和（ii）得到的两种反应溶液混合; 和（iv）向步骤（iii）中混合的溶液中加入碱以在搅拌下将pH调节至6-7。 在式11中，R，R1和R2与上述相同。

公开(公告)号：KR100832742B1

公开(公告)日：2008-05-27

申请号：KR1020070020220

申请日：2007-02-28

Applicant: 한국화학연구원

Inventor： 이현규 ,  박명순 ,  박창식 ,  박현규 ,  이현일 ,  임성윤

IPC: C12Q1/68

CPC classification number: C07K9/003 ,  C12Q1/6837 ,  C12Q1/6876

Abstract: A PNA(peptide nucleic acid) probe, a method for preparing a microarray using the same and a method for controlling quality of the PNA microarray are provided to measure the fixation efficiency non-destructively simultaneously on fixation without further operation. A PNA probe is characterized in that a 3-azidocumarine derivative represented by a formula(1) or (2) as a fluorescent linker is attached to an N-terminal, wherein m is from 0 to 4; n is from 1 to 4; p is from 0 to 3; q is 0 or 1; r is from 1 to 5; and X is O or NH. A method for preparing a PNA microarray comprises a step of fixing the PNA probe onto a solid substrate, which is modified to have an acetylene end, by spotting the PNA probe using a spotting solution including a Cu catalyst. A method for controlling quality of the PNA microarray comprises the steps of: (a) preparing the microarray by spotting the PNA probe onto the modified solid substrate; and (b) measuring the fixation efficiency by detecting a fluorescent signal emitted from spots of the PNA probe.

Abstract translation: 提供PNA（肽核酸）探针，使用其制备微阵列的方法和控制PNA微阵列质量的方法，用于在不进一步操作的情况下无损地同时测量固定效率。 PNA探针的特征在于，将由式（1）或（2）表示的3-叠氮胞菌素衍生物作为荧光接头连接到N-末端，其中m为0至4; n为1至4; p为0〜3; q为0或1; r为1〜5; X为O或NH。 制备PNA微阵列的方法包括通过使用包含Cu催化剂的斑点溶液点样PNA探针，将PNA探针固定在固体基底上的步骤，其被修饰为具有乙炔末端。 用于控制PNA微阵列质量的方法包括以下步骤：（a）通过将PNA探针点样到改性固体基质上来制备微阵列; 和（b）通过检测从PNA探针的斑点发射的荧光信号来测量固色效率。

公开(公告)号：KR1020020031450A

公开(公告)日：2002-05-02

申请号：KR1020000061923

申请日：2000-10-20

Applicant: 한국화학연구원

Inventor： 오세화 ,  전근 ,  신종일 ,  신승림 ,  김태경 ,  권은경 ,  김진수 ,  박명순

IPC: C09B46/00

Abstract: PURPOSE: Provided are pigment yellow based on quinoxaline which is ecofriendly and has excellent solvent resistance and colorfastness to light, and a method for preparing the same. CONSTITUTION: The pigment yellow based on quinoxaline represented by formula 1 is characterized in that it is prepared using aminoquinoxaline represented by formula 9, as a diazotized compound. In the formulas, R, R1 and R2 are the same or different, and hydrogen, C1-C4 alkyl group, nitro(-NO2), C1-C2 alkoxy group, C1-C18 heterocycle, methyl ester(COOCH3) or halogen group such as chloro or bromo. The pigment yellow is prepared by the steps of (i) diazotizing amino quinoxaline compound represented by formula 9; (ii) dissolving coupler represented by formula 11 into solvent; (iii) mixing two reaction solution obtained from the steps (i) and (ii) at 0-5 deg.C; and (iv) adding base to the solution mixed in the step(iii) to adjust pH to 6-7 with stirring. In the formula 11, R, R1 and R2 are the same as the above.

Abstract translation: 目的：提供基于喹喔啉的颜料黄，其是环保的并且具有优异的耐溶剂性和耐光色牢度及其制备方法。 构成：由式1表示的基于喹喔啉的颜料黄的特征在于使用由式9表示的氨基喹喔啉作为重氮化合物制备。 在式中，R 1，R 2和R 2相同或不同，氢，C 1 -C 4烷基，硝基（-NO 2），C 1 -C 2烷氧基，C 1 -C 18杂环，甲酯（COOCH 3） 作为氯或溴。 颜料黄由以下步骤制备：（i）重氮化由式9表示的氨基喹喔啉化合物; （ii）将由式11表示的成色剂溶解在溶剂中; （iii）在0-5℃下将由步骤（i）和（ii）获得的两种反应溶液混合; 和（iv）向步骤（iii）中混合的溶液中加入碱以在搅拌下将pH调节至6-7。 在式11中，R，R 1和R 2与上述相同。