公开(公告)号：WO2009023539A3

公开(公告)日：2009-03-19

申请号：PCT/US2008072560

申请日：2008-08-08

Applicant: ABBOTT LAB ,  KYM PHILIP R ,  BROWN BRIAN S ,  DAANEN JEROME F ,  GOMTSYAN ARTHUR R ,  KEDDY RYAN G ,  KORT MICHAEL ,  MATULENKO MARK A ,  VASUDEVAN ANIL

Inventor： KYM PHILIP R ,  BROWN BRIAN S ,  DAANEN JEROME F ,  GOMTSYAN ARTHUR R ,  KEDDY RYAN G ,  KORT MICHAEL ,  MATULENKO MARK A ,  VASUDEVAN ANIL

IPC: C07D401/04 ,  A61K31/4545

CPC classification number: C07D401/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, and R3, are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药盐或其组合，其中R1，R2和R3在本说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：BG65261B1

公开(公告)日：2007-10-31

申请号：BG10552301

申请日：2001-05-19

Applicant: ABBOTT LAB

Inventor： BLACK LAWRENCE ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT MICHAEL ,  LIU HUAQING ,  MCCARTY CATHERINE ,  PATEL MEENA ,  ROHDE JEFFREY ,  COGHLAN MICHAEL ,  STEWART ANDREW

IPC: C07D237/14 ,  A61K31/50 ,  A61K31/501 ,  A61P19/02 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06

Abstract: The present invention describes pyridazoline compounds of formula which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX 2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COC-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal(GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marked non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：BG64675B1

公开(公告)日：2005-11-30

申请号：BG10424100

申请日：2000-03-15

Applicant: ABBOTT LAB

Inventor： BLACK LAWRENCE ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT MICHAEL ,  LIU HUAQING ,  MCCARTY CATHERINE ,  PATEL MEENA ,  RHODE JEFFREY

IPC: C07D237/14 ,  A61K31/496 ,  A61K31/50 ,  A61K31/501 ,  A61K31/5377 ,  A61P5/00 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D237/10 ,  C07D237/16 ,  C07D237/18 ,  C07D237/20 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F9/547 ,  C07F9/6509 ,  C07F11/00

Abstract: The pyridazinon compounds are selective inhibitors of cyclooxygenase (COX), in particular of cyclooxygenase-2 (COX/2), COX-2 - inducible isoform which is related to the respective inflammation, as opposite to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important enzyme in many tissues, including the gastrointestinal tract and in the kidneys. The selectivity of the COX-2 compounds reduces to a minimum the unwanted side effects in the gastrointestinal tract and in the kidneys observed in the so-far knowm nonsteroid antiphlogistic medicaments.

公开(公告)号：MX2010001486A

公开(公告)日：2010-03-01

申请号：MX2010001486

申请日：2008-08-08

Applicant: ABBOTT LAB

Inventor： VASUDEVAN ANIL ,  BROWN BRIAN S ,  GOMTSYAN ARTHUR R ,  KEDDY RYAN G ,  DAANEN JEROME F ,  KYM PHILIP R ,  KORT MICHAEL ,  MATULENKO MARK A

IPC: C07D401/04 ,  A61K31/4545

Abstract: La presente invención se refiere a compuestos de la fórmula (I), o sales farmacéuticamente aceptables, profármacos, sales de profármacos, o combinaciones de los mismos, en donde R1, R2 y R3, son definidos en la descripción. También se describen composiciones que comprenden dichos compuestos y métodos pata el tratamiento de padecimientos y enfermedades utilizando dichos compuestos y composiciones.

公开(公告)号：AT401310T

公开(公告)日：2008-08-15

申请号：AT02714958

申请日：2002-01-17

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT J ,  BAI HAO ,  BRIONI JORGE ,  CARROL WILLIAM ,  GOPALAKRISHNAN MURALI ,  HOLLADAY MARK W ,  HUANG PEGGY ,  KINCAID JOHN ,  KORT MICHAEL ,  KYM PHILIP ,  LYNCH JOHN ,  PEREZ-MEDRANO ARTURO ,  ZHANG HENRY ,  GREGG ROBERT

IPC: C07D213/75 ,  A61K31/17 ,  A61K31/275 ,  A61K31/4164 ,  A61K31/4406 ,  A61K31/455 ,  A61K31/47 ,  A61K31/505 ,  A61P1/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/06 ,  A61P15/10 ,  A61P17/00 ,  A61P17/14 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07C233/36 ,  C07C233/78 ,  C07C233/83 ,  C07C255/61 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07C335/20 ,  C07D209/08 ,  C07D209/30 ,  C07D213/40 ,  C07D213/74 ,  C07D213/82 ,  C07D215/38 ,  C07D233/42 ,  C07D233/84 ,  C07D235/06 ,  C07D239/42 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：AT382620T

公开(公告)日：2008-01-15

申请号：AT99960168

申请日：1999-10-28

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM ,  AGRIOS KONSTANTINOS ,  ALTENBACH ROBERT ,  DRIZIN IRENE ,  KORT MICHAEL

IPC: C07D335/02 ,  C07D471/04 ,  A61K20060101 ,  A61K31/436 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/47 ,  A61K31/55 ,  A61P20060101 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C205/44 ,  C07D20060101 ,  C07D211/86 ,  C07D219/00 ,  C07D309/30 ,  C07D471/14 ,  C07D491/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/14 ,  C07D491/147 ,  C07D491/153 ,  C07D495/04 ,  C07D495/14 ,  C07D513/00

Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

公开(公告)号：CA2708320A1

公开(公告)日：2009-02-19

申请号：CA2708320

申请日：2008-08-08

Applicant: ABBOTT LAB

Inventor： KYM PHILIP R ,  BROWN BRIAN S ,  DAANEN JEROME F ,  GOMTSYAN ARTHUR R ,  KEDDY RYAN G ,  KORT MICHAEL ,  MATULENKO MARK A ,  VASUDEVAN ANIL

IPC: C07D401/04 ,  A61K31/4545

Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, and R3, are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：AT373642T

公开(公告)日：2007-10-15

申请号：AT00955327

申请日：2000-08-02

Applicant: ABBOTT LAB

Inventor： ALTENBACH ROBERT ,  BAI HAO ,  BRIONI JORGE ,  CARROLL WILLIAM ,  GOPALAKRISHNAN MURALI ,  GREGG ROBERT ,  HOLLADAY MARK ,  HUANG PEGGY ,  KINCAID JOHN ,  KORT MICHAEL ,  KYM PHILIP ,  LYNCH JOHN ,  PEREZ-MEDRANO ARTURO ,  ZHANG HENRY

IPC: C07D213/74 ,  C07D249/18 ,  A61K31/166 ,  A61K31/17 ,  A61K31/417 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/47 ,  A61P1/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P15/00 ,  A61P15/10 ,  A61P17/14 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C275/54 ,  C07C279/22 ,  C07C279/28 ,  C07C279/30 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07C335/26 ,  C07D209/08 ,  C07D213/75 ,  C07D215/38 ,  C07D233/02 ,  C07D233/42 ,  C07D235/06 ,  C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12