公开(公告)号：DE69025472D1

公开(公告)日：1996-03-28

申请号：DE69025472

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT ,  KEBABIAN JOHN ,  MARTIN YVONNE ,  DENINNO MICHAEL ,  PERNER RICHARD ,  STOUT DAVID ,  HSIAO CHI-NUNG ,  DIDOMENICO STANLEY ,  DEBERNARDIS JOHN ,  BASHA FATIMA ,  MEYER MICHEAL ,  DE BISWANATH ,  EHRLICH PAUL ,  CAMPBELL JAMES ,  MORTON HOWARD ,  LIJEWSKI LINDA

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/335 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/30 ,  C07C41/02 ,  C07C215/48 ,  C07C215/64 ,  C07C217/56 ,  C07C217/74 ,  C07C219/28 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D209/08 ,  C07D209/62 ,  C07D221/06 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D313/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D493/10 ,  C07K5/06 ,  C07D409/04 ,  C07D311/74 ,  C07D487/00 ,  C07D209/56 ,  C07D211/00 ,  C07C69/76 ,  A01N43/32 ,  A01N43/16 ,  A01N43/42 ,  A01N43/62

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

公开(公告)号：DE69420421D1

公开(公告)日：1999-10-07

申请号：DE69420421

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY ,  KERDESKY FRANCIS ,  LIJEWSKI LINDA ,  NORBECK DANIEL ,  SCARPETTI DAVID ,  TIEN JIEN-HEH ,  ALLEN MICHAEL ,  LANGRIDGE DENTON ,  MELCHER LAURA ,  RENO DANIEL ,  SHAM HING ,  ZHAO CHEN ,  HAIGHT ANTHONY ,  LEANNA M ,  MORTON HOWARD ,  ROBBINS TIMOTHY ,  SOWIN THOMAS

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：DE69025472T2

公开(公告)日：1996-10-17

申请号：DE69025472

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT ,  KEBABIAN JOHN ,  MARTIN YVONNE ,  DENINNO MICHAEL ,  PERNER RICHARD ,  STOUT DAVID ,  HSIAO CHI-NUNG ,  DIDOMENICO STANLEY ,  DEBERNARDIS JOHN ,  BASHA FATIMA ,  MEYER MICHEAL ,  DE BISWANATH ,  EHRLICH PAUL ,  CAMPBELL JAMES ,  MORTON HOWARD ,  LIJEWSKI LINDA

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/335 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/30 ,  C07C41/02 ,  C07C215/48 ,  C07C215/64 ,  C07C217/56 ,  C07C217/74 ,  C07C219/28 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D209/08 ,  C07D209/62 ,  C07D221/06 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D313/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D493/10 ,  C07K5/06 ,  C07D409/04 ,  C07D311/74 ,  C07D487/00 ,  C07D209/56 ,  C07D211/00 ,  C07C69/76 ,  A01N43/32 ,  A01N43/16 ,  A01N43/42 ,  A01N43/62

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.