公开(公告)号：CA2647592C

公开(公告)日：2014-01-28

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： DIEBOLD ROBERT B ,  DJURIC STEVAN W ,  GIRANDA VINCENT L ,  HEXAMER LAURA ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  TONG YUNSONG ,  VASUDEVAN ANIL ,  WANG LE ,  WOODS KEITH W ,  XIA ZHIREN ,  ZHANG HENRY Q

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (see formula I) wherein X1, C1, and D1 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting Plk1, Plk1 causes mitotic arrest, and inhibitors of Plk1 are cytotoxic agents that are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：MX2008015004A

公开(公告)日：2008-12-05

申请号：MX2008015004

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： HEXAMER LAURA ,  WANG LE ,  TONG YUNSONG ,  DJURIC STEVAN W ,  XIA ZHIREN ,  ZHANG HENRY Q ,  PENNING THOMAS D ,  GIRANDA VINCENT L ,  DIEBOLD ROBERT B ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  VASUDEVAN ANIL ,  WOODS KEITH W

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Se describen compuestos que inhiben Plk1, composiciones que contienen los compuestos y métodos para tratar enfermedades utilizando los compuestos.

公开(公告)号：CA2647592A1

公开(公告)日：2007-12-06

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： PRZYTULINSKA MAGDALENA ,  VASUDEVAN ANIL ,  TONG YUNSONG ,  DIEBOLD ROBERT B ,  SOWIN THOMAS ,  LIN NAN-HORNG ,  XIA ZHIREN ,  PENNING THOMAS D ,  WOODS KEITH W ,  WANG LE ,  DJURIC STEVAN W ,  MIYASHIRO JULIE M ,  ZHANG HENRY Q ,  TAO ZHI-FU ,  SULLIVAN GERARD ,  HEXAMER LAURA ,  GIRANDA VINCENT L

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：DE10199053I1

公开(公告)日：2002-08-29

申请号：DE10199053

申请日：1993-12-16

Applicant: ABBOTT LAB

Inventor： KEMPF DALE ,  NORBECK DANIEL ,  SHAM HING LEUNG ,  ZHAO CHEN ,  SOWIN THOMAS ,  RENO DANIEL ,  HAIGHT ANTHONY ,  COOPER ARTHUR

IPC: C07D275/02 ,  A61K31/395 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K38/00 ,  A61K45/06 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  A61P43/00 ,  C07C33/46 ,  C07C43/164 ,  C07C43/174 ,  C07C43/205 ,  C07C43/215 ,  C07C43/23 ,  C07C43/30 ,  C07C43/315 ,  C07C45/00 ,  C07C45/29 ,  C07C45/56 ,  C07C45/62 ,  C07C45/67 ,  C07C45/74 ,  C07C53/134 ,  C07C69/34 ,  C07C69/65 ,  C07C69/732 ,  C07C211/27 ,  C07C215/18 ,  C07C215/20 ,  C07C215/28 ,  C07C229/08 ,  C07C229/26 ,  C07C229/34 ,  C07C233/36 ,  C07C233/40 ,  C07C235/10 ,  C07C235/12 ,  C07C235/34 ,  C07C235/78 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/10 ,  C07C239/18 ,  C07C239/20 ,  C07C247/10 ,  C07C251/40 ,  C07C271/20 ,  C07C271/22 ,  C07C271/34 ,  C07C275/16 ,  C07C275/24 ,  C07C311/03 ,  C07C311/13 ,  C07C311/18 ,  C07C317/10 ,  C07C317/28 ,  C07C317/44 ,  C07C323/12 ,  C07C323/25 ,  C07C381/00 ,  C07D20060101 ,  C07D213/26 ,  C07D213/30 ,  C07D213/34 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/75 ,  C07D233/54 ,  C07D233/84 ,  C07D235/10 ,  C07D235/14 ,  C07D235/16 ,  C07D239/26 ,  C07D241/12 ,  C07D261/06 ,  C07D261/08 ,  C07D263/24 ,  C07D263/30 ,  C07D263/32 ,  C07D263/48 ,  C07D265/30 ,  C07D277/22 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/32 ,  C07D277/34 ,  C07D277/36 ,  C07D277/40 ,  C07D277/42 ,  C07D277/56 ,  C07D295/13 ,  C07D295/205 ,  C07D295/215 ,  C07D303/36 ,  C07D307/42 ,  C07D333/16 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00 ,  C07F5/02 ,  C07F5/04 ,  C07K5/06 ,  C07K5/065

Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.

公开(公告)号：DE69420421T2

公开(公告)日：2000-05-04

申请号：DE69420421

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY ,  KERDESKY FRANCIS ,  LIJEWSKI-LINCH LINDA M ,  NORBECK DANIEL ,  SCARPETTI DAVID ,  TIEN JIEN-HEH ,  ALLEN MICHAEL ,  LANGRIDGE DENTON ,  MELCHER LAURA ,  RENO DANIEL ,  SHAM HING ,  ZHAO CHEN ,  HAIGHT ANTHONY ,  LEANNA M ,  MORTON HOWARD ,  ROBBINS TIMOTHY ,  SOWIN THOMAS

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：DE69420421D1

公开(公告)日：1999-10-07

申请号：DE69420421

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY ,  KERDESKY FRANCIS ,  LIJEWSKI LINDA ,  NORBECK DANIEL ,  SCARPETTI DAVID ,  TIEN JIEN-HEH ,  ALLEN MICHAEL ,  LANGRIDGE DENTON ,  MELCHER LAURA ,  RENO DANIEL ,  SHAM HING ,  ZHAO CHEN ,  HAIGHT ANTHONY ,  LEANNA M ,  MORTON HOWARD ,  ROBBINS TIMOTHY ,  SOWIN THOMAS

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.