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1.发明申请MUTANT PEPTIDES DERIVED FROM BAD AND THEIR USE TO IDENTIFY SUBSTANCES WHICH BIND TO A MEMBER OF THE BCL-2 FAMILY OF PROTEINS 审中-公开从BAD衍生的突变体及其用于识别BCL-2蛋白家族成员的物质
公开(公告)号：WO0220568A3
公开(公告)日：2002-09-26
申请号：PCT/US0127410
申请日：2001-09-04
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , MEADOWS ROBERT P , JOSEPH MARY K , OLEJNICZAK EDWARD T , PETROS ANDREW M , NETTESHEIM DAVID G , SWIFT KERRY M , MATAYOSHI EDMUND , ZHANG HAICHAO
CPC classification number: C07K14/4702
Abstract: The present invention relates to peptides derived from the wild-type human Bad peptide which bind to a member of the Bcl-2 family of proteins. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
Abstract translation: 本发明涉及衍生自与蛋白质Bcl-2家族成员结合的野生型人Bad肽的肽。 本发明的肽可用于测定诱导或促进细胞凋亡的候选物质。
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2.发明申请
公开(公告)号：WO0230959A3
公开(公告)日：2002-09-26
申请号：PCT/US0132121
申请日：2001-10-12
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , MEADOWS ROBERT P , BETZ STEPHEN P , LIU ZHIHONG , OLEJNICZAK EDWARD T , SUN CHAOHONG
CPC classification number: C07K14/8139 , C07K14/4702
Abstract: The present invention relates to peptides derived from the wildtype human smac (DIABLO) protein which binds to a member of an IAP family member. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
Abstract translation: 本发明涉及衍生自与IAP家族成员结合的野生型人类smac（DIABLO）蛋白质的肽。 本发明的肽可用于测定诱导或促进细胞凋亡的候选物质。
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