公开(公告)号：WO2008082887A3

公开(公告)日：2008-12-04

申请号：PCT/US2007087250

申请日：2007-12-12

Applicant: ABBOTT LAB ,  GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  WOODS KEITH W

Inventor： GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  WOODS KEITH W

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

CPC classification number: C07D241/08 ,  C07D241/44 ,  C07D243/08 ,  C07D243/14 ,  C07D471/04 ,  C07D487/04

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

Abstract translation: 公开了聚（ADP-核糖）聚合酶抑制剂，使其制备方法和使用它们治疗患者的方法。

公开(公告)号：CA2672860C

公开(公告)日：2013-01-29

申请号：CA2672860

申请日：2007-12-12

Applicant: ABBOTT LAB

Inventor： GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  WOODS KEITH W

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.

公开(公告)号：MX2009007053A

公开(公告)日：2009-07-09

申请号：MX2009007053

申请日：2007-12-12

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  WOODS KEITH W

IPC: A61K31/4188 ,  C07D487/04 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

Abstract: Se describen inhibidores de poli(ADP-ribosa)polimerasa, formas para elaborarlos y métodos para tratar pacientes utilizándolos tal como se describe.

公开(公告)号：MX2008015004A

公开(公告)日：2008-12-05

申请号：MX2008015004

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： HEXAMER LAURA ,  WANG LE ,  TONG YUNSONG ,  DJURIC STEVAN W ,  XIA ZHIREN ,  ZHANG HENRY Q ,  PENNING THOMAS D ,  GIRANDA VINCENT L ,  DIEBOLD ROBERT B ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  VASUDEVAN ANIL ,  WOODS KEITH W

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Se describen compuestos que inhiben Plk1, composiciones que contienen los compuestos y métodos para tratar enfermedades utilizando los compuestos.

公开(公告)号：CA2647592A1

公开(公告)日：2007-12-06

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： PRZYTULINSKA MAGDALENA ,  VASUDEVAN ANIL ,  TONG YUNSONG ,  DIEBOLD ROBERT B ,  SOWIN THOMAS ,  LIN NAN-HORNG ,  XIA ZHIREN ,  PENNING THOMAS D ,  WOODS KEITH W ,  WANG LE ,  DJURIC STEVAN W ,  MIYASHIRO JULIE M ,  ZHANG HENRY Q ,  TAO ZHI-FU ,  SULLIVAN GERARD ,  HEXAMER LAURA ,  GIRANDA VINCENT L

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：CA2647592C

公开(公告)日：2014-01-28

申请号：CA2647592

申请日：2007-05-24

Applicant: ABBOTT LAB

Inventor： DIEBOLD ROBERT B ,  DJURIC STEVAN W ,  GIRANDA VINCENT L ,  HEXAMER LAURA ,  LIN NAN-HORNG ,  MIYASHIRO JULIE M ,  PENNING THOMAS D ,  PRZYTULINSKA MAGDALENA ,  SOWIN THOMAS ,  SULLIVAN GERARD ,  TAO ZHI-FU ,  TONG YUNSONG ,  VASUDEVAN ANIL ,  WANG LE ,  WOODS KEITH W ,  XIA ZHIREN ,  ZHANG HENRY Q

IPC: C07C225/20 ,  A61K31/132 ,  A61K31/505 ,  A61P35/00 ,  C07D249/14 ,  C07D277/64 ,  C07D285/06 ,  C07D333/20

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (see formula I) wherein X1, C1, and D1 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting Plk1, Plk1 causes mitotic arrest, and inhibitors of Plk1 are cytotoxic agents that are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.

公开(公告)号：CA2672860A1

公开(公告)日：2008-07-10

申请号：CA2672860

申请日：2007-12-12

Applicant: ABBOTT LAB

Inventor： WOODS KEITH W ,  GIRANDA VINCENT L ,  MIYASHIRO JULIE M ,  PENNING THOMAS D

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5513 ,  A61K31/5517 ,  C07D241/06 ,  C07D241/36 ,  C07D243/14

Abstract: Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods o f treating patients using them are disclosed.