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公开(公告)号：WO2007079164A2
公开(公告)日：2007-07-12
申请号：PCT/US2006049461
申请日：2006-12-28
Applicant: ABBOTT LAB , SHEPPARD GEORGE , WANG GARY , PALAZZO FABIO , BELL RANDY , MANTEI ROBERT , WANG JIEYI , HUBBARD ROBERT , KAWAI MEGUMI , ERICKSON SCOTT , BAMAUNG NWE , FIDANZE STEVE
Inventor： SHEPPARD GEORGE , WANG GARY , PALAZZO FABIO , BELL RANDY , MANTEI ROBERT , WANG JIEYI , HUBBARD ROBERT , KAWAI MEGUMI , ERICKSON SCOTT , BAMAUNG NWE , FIDANZE STEVE
CPC classification number: C07D487/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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2.发明申请3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS 审中-公开3-取代的吲哚乙酸可用作细胞增殖和血管生成抑制剂
公开(公告)号：WO0222576A3
公开(公告)日：2002-07-04
申请号：PCT/US0128789
申请日：2001-09-14
Applicant: ABBOTT LAB
Inventor： BAMAUNG NWE Y , CRAIG RICHARD A , KAWAI MEGUMI , WANG JIEYI , DAI YUJIA , GUO YAN , SHEPPARD GEORGE , VERZAL MARY K , VASUDEVAN ANIL , MICHAELLIDES MICHAEL R
IPC: A61P35/00 , A61P43/00 , C07D209/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/404
CPC classification number: C07D209/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: 3-Substituted indole carbohydrazides having the formula (I), are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.
Abstract translation: 具有式（I）的3-取代的吲哚碳酰肼可用于抑制血管生成和细胞增殖。 还公开了抑制血管发生和细胞增殖的组合物以及抑制哺乳动物血管生成和癌症的方法。
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Patent Agency Ranking
公开(公告)号：DE69228932T2
公开(公告)日：1999-11-11
申请号：DE69228932
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES , DAVIDSEN STEVEN , HOLMS JAMES , PIREH DAISY , HEYMAN H , MARTIN MICHAEL , STEINMAN DOUGLAS , SHEPPARD GEORGE , CARRERA GEORGE
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：CA2112562A1
公开(公告)日：1993-02-04
申请号：CA2112562
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE , CARRERA GEORGE M JR
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00 , A61K31/495 , A61K31/535 , A61K31/54
Abstract: 2112562 9301813 PCTABS00019 Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo¢1,2-c!pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：DE69228932D1
公开(公告)日：1999-05-20
申请号：DE69228932
申请日：1992-07-14
Applicant: ABBOTT LAB
Inventor： SUMMERS JAMES , DAVIDSEN STEVEN , HOLMS JAMES , PIREH DAISY , HEYMAN H , MARTIN MICHAEL , STEINMAN DOUGLAS , SHEPPARD GEORGE , CARRERA GEORGE
IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
Abstract: PCT No. PCT/US92/05890 Sec. 371 Date Dec. 2, 1993 Sec. 102(e) Date Dec. 2, 1993 PCT Filed Jul. 14, 1992 PCT Pub. No. WO93/01813 PCT Pub. Date Feb. 4, 1993.Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
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公开(公告)号：CA2635231C
公开(公告)日：2014-07-15
申请号：CA2635231
申请日：2006-12-28
Applicant: ABBOTT LAB
Inventor： SHEPPARD GEORGE , WANG GARY , PALAZZO FABIO , BELL RANDY , MANTEI ROBERT , WANG JIEYI , HUBBARD ROBERT , KAWAI MEGUMI , ERICKSON SCOTT , BAMAUNG NWE , FIDANZE STEVE
IPC: C07D487/04 , A61K31/4985 , A61K31/519 , A61P35/00
Abstract: Compounds of formula (I) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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公开(公告)号：CA2635231A1
公开(公告)日：2007-07-12
申请号：CA2635231
申请日：2006-12-28
Applicant: ABBOTT LAB
Inventor： WANG GARY , PALAZZO FABIO , MANTEI ROBERT , WANG JIEYI , FIDANZE STEVE , BAMAUNG NWE , ERICKSON SCOTT , HUBBARD ROBERT , KAWAI MEGUMI , BELL RANDY , SHEPPARD GEORGE
IPC: C07D487/04 , A61K31/4985 , A61K31/519 , A61P35/00
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