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公开(公告)号：WO0058314A3
公开(公告)日：2001-02-22
申请号：PCT/US0007641
申请日：2000-03-23
Applicant: ABBOTT LAB
Inventor： KAWAI MEGUMI , GUNAWARDANA INDRANI W
IPC: C07D498/08 , A61K31/539 , A61P17/04 , A61P17/06 , A61P17/10 , A61P37/00 , A61P37/02 , A61P37/08 , C07D498/18 , A61K31/407 , A61K31/4353
CPC classification number: C07D498/18
Abstract: The present invention relates to novel compounds of formula (I), which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the preparation of compounds of formula (I), compositions containing such compounds, and methods of using such compounds.
Abstract translation: 本发明涉及新的式（I）化合物，其可用作免疫调节剂，特别是大环内酯类免疫抑制剂。 本发明还涉及制备式（I）化合物，含有这些化合物的组合物，以及使用这些化合物的方法。
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2.发明申请
公开(公告)号：WO0039081A3
公开(公告)日：2001-05-25
申请号：PCT/US9931162
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , BOYD STEVEN A , JAE HWAN-SOO , LYNCH JOHN K , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/10 , A61K31/33 , C07D295/20
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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公开(公告)号：WO9962908A3
公开(公告)日：2000-03-30
申请号：PCT/US9912419
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）的化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：HRP20010776A2
公开(公告)日：2002-12-31
申请号：HRP20010776
申请日：2001-10-23
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN THOMAS W VON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：HU0200222A2
公开(公告)日：2002-06-29
申请号：HU0200222
申请日：1999-12-29
Applicant: ABBOTT LAB
Inventor： BOYD STEVEN A , FREEMAN JENNIFER C , VON GELDERN TOM , GUNAWARDANA INDRANI W , JAE HWAN-SOO , LINK JAMES , LIU GANG , LYNCH JOHN K , PEI ZHONGHUA , STAEGER MICHAEL A , WINN MARTIN , XIN ZHILI , ZHU GUI-DONG
IPC: C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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Patent Agency Ranking
公开(公告)号：HK1040985A1
公开(公告)日：2002-06-28
申请号：HK02102655
申请日：2002-04-09
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN VON THOMAS W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00 , C07C , C07D , A61K , A61P
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：MXPA01009935A
公开(公告)日：2002-05-06
申请号：MXPA01009935
申请日：2000-03-23
Applicant: ABBOTT LAB
Inventor： GUNAWARDANA INDRANI W
IPC: A61K31/661 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/14 , A61P37/00 , A61P37/06 , C07F9/6561 , A61K31/675
Abstract: La presente invencion se refiere a nuevos compuestos de la formula (1) que son utiles como inmunomoduladores, en particular, inmunosupresores de macrolido. La invencion se refiere a la preparacion de los compuestos de la formula (1), composiciones que contienen tales compuestos y metodos para utilizar tales compuestos.
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公开(公告)号：BR9910864A
公开(公告)日：2002-02-05
申请号：BR9910864
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：HU0102366A2
公开(公告)日：2001-11-28
申请号：HU0102366
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： ARENDSEN DAVID L , BHATIA PRAMILA , BOYD STEVEN A , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STEWART ANDREW O , STOUT DAVID M , ZHU GUI-DONG
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：CA2369238A1
公开(公告)日：2000-10-12
申请号：CA2369238
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： XIN ZHILI , WINN MARTIN , LYNCH JOHN K , JAE HWAN-SOO , LIU GANG , WANG SHELDON , VON GELDERN THOMAS W , PEI ZHONGHUA , ZHU GUI-DONG , BOYD STEVEN A , LINK JAMES , FREEMAN JENNIFER C , STAEGER MICHAEL A , GUNAWARDANA INDRANI W
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in whic h at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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