公开(公告)号：WO2006124813A2

公开(公告)日：2006-11-23

申请号：PCT/US2006018796

申请日：2006-05-16

Applicant: ABBOTT LAB ,  GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  STEWART KENT D ,  ZANZE IRINI

Inventor： GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  STEWART KENT D ,  ZANZE IRINI

CPC classification number: C07D487/04

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：CA2608974C

公开(公告)日：2014-03-18

申请号：CA2608974

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  STEWART KENT D ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551 ,  A61P35/00

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：ES2378779T3

公开(公告)日：2012-04-17

申请号：ES06759877

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： GRACIAS VIJAYA ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN ,  JI ZHIQIN ,  MICHAELIDES MICHAEL ,  STEWART KENT ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551

Abstract: Un compuesto seleccionado del grupo que consiste en: N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-fenilurea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-fenilurea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[3-(trifluorometil)fenil]urea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(4-fluoro-3-metilfenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(2-fluoro-5-metilfenil)urea; N-[5-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)-2a metilfenil]-N'-[3-(trifluorometil)fenil]urea; N-[5-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)-2-metilfenil]-N'-(2-fluoro-5-metilfenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[2-fluoro-5-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-cloro-3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(3-clorofenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-fluoro-3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(3-bromofenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[2-fluoro-3-(trifluorometil)fenil]urea; y N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-3-[3-(trifluorometil)fenil]acrilamida.

公开(公告)号：AT540951T

公开(公告)日：2012-01-15

申请号：AT06759877

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： GRACIAS VIJAYA ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN ,  JI ZHIQIN ,  MICHAELIDES MICHAEL ,  STEWART KENT ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：MX2007014384A

公开(公告)日：2008-02-12

申请号：MX2007014384

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  STEWART KENT D ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551 ,  A61P35/00

Abstract: Los compuestos que tienen la formula (I) (ver formula (I)) son utiles para inhibir tirosina-quinasas de proteina. La presente invencion describe tambien metodos para preparar los compuestos; composiciones que contienen los compuestos, y metodos de tratamiento que utilizan los compuestos.

公开(公告)号：CA2608974A1

公开(公告)日：2006-11-23

申请号：CA2608974

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： ABAD-ZAPATERO CELERINO ,  GRACIAS VIJAYA J ,  STEWART KENT D ,  MICHAELIDES MICHAEL R ,  JI ZHIQIN ,  DJURIC STEVAN W ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551 ,  A61P35/00

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.