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1.发明申请SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO[4,5-B] [1,4] DIAZEPIN-4-AMINES ARE NOVEL KINASE INHIBITORS 审中-公开取代的7,8-二氢-1H-吡咯并[4,5-B] [1,4]二氮杂-4-胺是新型激酶抑制剂
公开(公告)号：WO2006124813A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018796
申请日：2006-05-16
Applicant: ABBOTT LAB , GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
Inventor： GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
CPC classification number: C07D487/04
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：ZA200908624B
公开(公告)日：2015-08-26
申请号：ZA200908624
申请日：2009-12-04
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： FRANK KRISTINE , GEORGE DAWN , ST JOHN MOORE NIGEL , VASUDEVAN ANIL , LONG ANDREW J , KOVAR PETER J , JOHNSON ERIC T , TEUSCH NICOLE , BAKKER MARGARETHA , MICHMERHUIZEN MELISSA J , KALVIN DOUGLAS M , SARRIS KATHY , GRACIAS VIJAYA J , GASIECKI ALAN F , WAKEFIELD BRIAN D , AKRITOPOULOU-ZANZE IRINI , HOBSON ADRIAN D , WANG LU , PATEL JYOTI R , SHUAI QI , TURNER SEAN C , DJURIC STEVAN W , MACK HELMUT , LI BIQIN
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公开(公告)号：CA2689117A1
公开(公告)日：2008-12-18
申请号：CA2689117
申请日：2008-06-04
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： WAKEFIELD BRIAN D , AKRITOPOULOU-ZANZE IRINI , MACK HELMUT , FRANK KRISTINE , LI BIQIN , VASUDEVAN ANIL , HOBSON ADRIAN , LONG ANDREW J , DJURIC STEVAN W , KOVAR PETER J , JOHNSON ERIC T , TURNER SEAN C , GEORGE DAWN , GASIECKI ALAN F , WANG LU , ST JOHN MOORE NIGEL , MICHMERHUIZEN MELISSA J , GRACIAS VIJAYA J , SARRIS KATHY , KALVIN DOUGLAS M , SHUAI QI , PATEL JYOTI R , BAKKER MARGARETHA , TEUSCH NICOLE
IPC: C07D403/04 , C07D413/04 , C07D417/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutic al acceptable salts, wherein A, R1, R2, R3 and m, are defined in the descrip tion. The present invention relates also to methods of making said compounds , and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janu s Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
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公开(公告)号：CA2560691A1
公开(公告)日：2005-10-13
申请号：CA2560691
申请日：2005-03-24
Applicant: MAKOTO AOYAMA , ABBOTT LAB
Inventor： WADA CAROL K , STEINMAN DOUGLAS H , RAFFERTY PAUL , MAKOTO AOYAMA , XIA ZHIREN , MICHAELIDES MICHAEL R , MUCKEY MELANIE A , DINGES JUERGEN , HOLMS JAMES H , ZHANG HENRY Q , AKRITOPOULOU-ZANZE IRINI , DIXON RICHARD W , DJURIC STEVAN W , ERICSSON ANNA M , FISCHER KIMBA , GRACIAS VIJAYA J , ARNOLD LEE D , GASIECKI ALAN F
IPC: C07D409/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P37/00 , C07D231/54 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04
Abstract: Compounds of the present invention are useful for inhibiting protein tyrosin e kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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5.发明专利
公开(公告)号：CA2608974C
公开(公告)日：2014-03-18
申请号：CA2608974
申请日：2006-05-16
Applicant: ABBOTT LAB
Inventor： GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , JI ZHIQIN , MICHAELIDES MICHAEL R , STEWART KENT D , ZANZE IRINI
IPC: C07D487/04 , A61K31/551 , A61P35/00
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Patent Agency Ranking
公开(公告)号：SG182187A1
公开(公告)日：2012-07-30
申请号：SG2012043113
申请日：2008-06-04
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： AKRITOPOULOU-ZANZE IRINI , WAKEFIELD BRIAN D , MACK HELMUT , TURNER SEAN C , GASIECKI ALAN F , GRACIAS VIJAYA J , SARRIS KATHY , KALVIN DOUGLAS M , MICHMERHUIZEN MELISSA J , SHUAI QI , PATEL JYOTI R , BAKKER MARGARETHA , TEUSCH NICOLE , KOVAR PETER J , DJURIC STEVAN W , LONG ANDREW J , VASUDEVAN ANIL , HOBSON ADRIAN , ST JOHN MOORE NIGEL , WANG LU , GEORGE DAWN , LI BIQIN , FRANK KRISTINE , JOHNSON ERIC T
Abstract: 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORSAbstractThe present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein A, R1,R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Ala, PAK4, PLK, CK2, KDR, MK2, JNK I, aurora, pim I and nek 2.No suitable figure
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公开(公告)号：MXPA06010904A
公开(公告)日：2007-06-11
申请号：MXPA06010904
申请日：2005-03-24
Applicant: ABBOTT LAB
Inventor： MICHAELIDES MICHAEL R , HOLMS JAMES H , STEINMAN DOUGLAS H , MUCKEY MELANIE A , WADA CAROL K , ARNOLD LEE D , DINGES JURGEN , DIXON RICHARD W , DJURIC STEVAN W , ERICSSON ANNA M , FISCHER KIMBA , GASIECKI ALAN F , GRACIAS VIJAYA J , RAFFERTY PAUL , XIA ZHIREN , AKRITOPOULOU-ZANZE IRINI , ZHANG HENRY Q , TAKESHITA MAKOTO
IPC: C07D409/04 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P35/00 , A61P37/00 , C07D231/54 , C07D409/14 , C07D413/14 , C07D491/04 , C07D495/04
Abstract: Se utilizan los compuestos de la presente invencion para inhibir proteinas de tirosin-cinasas. Tambien se describen los metodos para hacer los compuestos, composiciones que los contienen y metodos de tratamiento utilizando los compuestos.
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公开(公告)号：MX2009013213A
公开(公告)日：2010-03-30
申请号：MX2009013213
申请日：2008-06-04
Applicant: ABBOTT LAB
Inventor： KALVIN DOUGLAS M , WANG LU , GASIECKI ALAN F , GRACIAS VIJAYA J , AKRITOPOULOU-ZANZE IRINI , LI BIQIN , PATEL JYOTI R , SHUAI QI , TURNER SEAN C , DJURIC STEVAN W , BAKKER MARGARETHA , VASUDEVAN ANIL , MICHMERHUIZEN MELISSA J , SARRIS KATHY , HOBSON ADRIAN , TEUSCH NICOLE , MACK HELMUT , WAKEFIELD BRIAN D , JOHNSON ERIC T , KOVAR PETER J , LONG ANDREW J , MOORE NIGEL ST JOHN , GEORGE DAWN , FRANK KRISTINE
IPC: C07D403/04 , C07D413/04 , C07D417/04
Abstract: La presente invención se refiere a compuestos de la fórmula (I) o sales farmacéuticamente aceptables, en donde A, R1, R2, R3 y m, son como se definieron en la descripción. La presente invención se refiere también a métodos para elaborar los compuestos, y composiciones que contienen los compuestos los cuales son útiles para inhibir las cinasas tales como Glicógeno Cintaza cinasa 3 (GSK-3), Rho cinasa (ROCK), Janus Cinasas (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 y nek 2.
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9.发明专利
公开(公告)号：MX2007014384A
公开(公告)日：2008-02-12
申请号：MX2007014384
申请日：2006-05-16
Applicant: ABBOTT LAB
Inventor： JI ZHIQIN , MICHAELIDES MICHAEL R , GRACIAS VIJAYA J , ABAD-ZAPATERO CELERINO , DJURIC STEVAN W , STEWART KENT D , ZANZE IRINI
IPC: C07D487/04 , A61K31/551 , A61P35/00
Abstract: Los compuestos que tienen la formula (I) (ver formula (I)) son utiles para inhibir tirosina-quinasas de proteina. La presente invencion describe tambien metodos para preparar los compuestos; composiciones que contienen los compuestos, y metodos de tratamiento que utilizan los compuestos.
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10.发明专利
公开(公告)号：CA2608974A1
公开(公告)日：2006-11-23
申请号：CA2608974
申请日：2006-05-16
Applicant: ABBOTT LAB
Inventor： ABAD-ZAPATERO CELERINO , GRACIAS VIJAYA J , STEWART KENT D , MICHAELIDES MICHAEL R , JI ZHIQIN , DJURIC STEVAN W , ZANZE IRINI
IPC: C07D487/04 , A61K31/551 , A61P35/00
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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