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公开(公告)号：WO2006114401A2
公开(公告)日：2006-11-02
申请号：PCT/EP2006061776
申请日：2006-04-24
Applicant: HOFFMANN LA ROCHE , GROEBKE-ZBINDEN KATRIN , HAAP WOLFGANG , HILPERT HANS , PANDAY NARENDRA , RICKLIN FABIENNE , WIRZ BEAT
Inventor： GROEBKE-ZBINDEN KATRIN , HAAP WOLFGANG , HILPERT HANS , PANDAY NARENDRA , RICKLIN FABIENNE , WIRZ BEAT
CPC classification number: C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D409/14 , C07D413/14 , C07D513/04
Abstract: The invention is concerned with novel cyclic amines of formula (I) wherein X 1 to X 3 , Y 1 to Y 3 , R 1' , R 1'' and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
Abstract translation: 本发明涉及新的式（I）的环胺，其中X 1至X 3，Y 1至Y 3， R 1，R 1，R 1和R 2如在说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa，并且可以用作药物。
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2.发明专利
公开(公告)号：BR112012024199A2
公开(公告)日：2016-07-05
申请号：BR112012024199
申请日：2011-03-23
Applicant: HOFFMANN LA ROCHE
Inventor： FLOHR ALEXANDER , KUHN BERND , PETERS JENS-UWE , GROEBKE-ZBINDEN KATRIN , BLEICHER KONRAD , GOBBI LUCA , RUDOLPH MARKUS , KOERNER MATTHIAS , SANCHÉZ RUBÉN ALVAREZ
IPC: C07D487/04 , A61K31/519 , A61P25/00 , A61P25/18 , C07D519/00
Abstract: derivados de n-(imidazopirimidin-7-il)-heteroarilamida e seu uso como inibidores de pde10a. a invenção está relacionada a novos derivados de imidazopirimidina de fórmula (i) em que r¹,r² e r são como definidos na descrição e nas reivindicações, bem como sais fisiologicamente aceitáveis e ésteres dos mesmos. estes compostos inibem pde10a e são usados como medicamentos.
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公开(公告)号：CA2604603A1
公开(公告)日：2006-11-02
申请号：CA2604603
申请日：2006-04-24
Applicant: HOFFMANN LA ROCHE
Inventor： RICKLIN FABIENNE , WIRZ BEAT , PANDAY NARENDRA , HILPERT HANS , HAAP WOLFGANG , GROEBKE-ZBINDEN KATRIN
IPC: C07D409/14 , A61K31/4025 , A61P7/02 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D413/14 , C07D513/04
Abstract: The invention is concerned with novel cyclic amines of formula (I) wherein X 1 to X3, Y1 to Y3, R1~ , R1~~ and n are as defined in the description and in t he claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：BRPI0609917A2
公开(公告)日：2010-05-11
申请号：BRPI0609917
申请日：2006-04-24
Applicant: HOFFMANN LA ROCHE
Inventor： GROEBKE-ZBINDEN KATRIN , HAAP WOLFGANG , HILPERT HANS , PANDAY NARENDRA , RICKLIN FABIENNE , WIRZ BEAT
IPC: C07D409/14 , A61K31/4025 , A61P7/02 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D413/14 , C07D513/04
Abstract: The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.
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公开(公告)号：NO20091721L
公开(公告)日：2009-07-28
申请号：NO20091721
申请日：2009-04-30
Applicant: HOFFMANN LA ROCHE
Inventor： GALLEY GUIDO , GROEBKE-ZBINDEN KATRIN , NORCROSS ROGER , STALDER HENRI
IPC: C07D403/06 , A61K31/4178 , A61P25/00 , C07D401/06 , C07D413/06
Abstract: The present invention relates to a compound of formula I, wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from the group consisting of hydrogen and lower alkyl; each R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, phenyloxy, benzyloxy, halogen and lower alkyl substituted by halogen; R4 is selected from the group consisting of hydrogen and lower alkyl; X is selected from the group consisting of —CH2—, —CH— and —O—; Y is selected from the group consisting of —CH2—, —CH2CH2—, —CH— and a bond; with the proviso that, when X is —O—, Y is —CH2—; Z is selected from the group consisting of —CH2— and —CH—; m is 1 or 2; and n is 1 or 2. The invention relates also to a pharmaceutically-acceptable acid-addition salt of such a compound, methods for making the compound, and a composition comprising such a compound. It has been found that the compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1.
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Patent Agency Ranking
公开(公告)号：NO20075158L
公开(公告)日：2007-11-23
申请号：NO20075158
申请日：2007-10-10
Applicant: HOFFMANN LA ROCHE
Inventor： WIRZ BEAT , HILPERT HANS , RICKLIN FABIENNE , HAAP WOLFGANG , PANDAY NARENDRA , GROEBKE-ZBINDEN KATRIN
IPC: C07D409/14 , A61K31/4427 , A61P7/02 , C07D207/10 , C07D401/14
Abstract: The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.
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公开(公告)号：CR20220118A
公开(公告)日：2022-04-20
申请号：CR20220118
申请日：2020-09-22
Applicant: HOFFMANN LA ROCHE
Inventor： GRETHER UWE , RICHTER HANS , KUHN BERND , HORNSPERGER BENOIT , LUTZ MARIUS DANIEL RINALDO , GOBBI LUCA , RITTER MARTIN , O`HARA FIONN , GROEBKE-ZBINDEN KATRIN , KROLL CARSTEN
IPC: A61P25/28 , A61K31/5375 , A61P25/00 , A61P25/24 , A61P35/00 , A61P37/00 , C07D491/04 , C07D498/04
Abstract: La invención proporciona nuevos compuestos heterocíclicos, que son inhibidores de monoacilglicerol lipasa (MAGL) que tienen la Fórmula general (I)
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公开(公告)号：CR20210056A
公开(公告)日：2021-03-02
申请号：CR20210056
申请日：2019-08-12
Applicant: HOFFMANN LA ROCHE
Inventor： KUHN BERND , HEER DOMINIK , RICHTER HANS , O`HARA FIONN , GRETHER UWE , BENZ JOERG , ANSELM LILLI , GROEBKE-ZBINDEN KATRIN , KROLL CARSTEN , HORNSPERGER BENOIT
IPC: A61P25/24 , A61K31/5365 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P35/00 , C07D498/04
Abstract: La invención proporciona nuevos compuestos heterocíclicos que tienen la fórmula general (I) en donde A, L, X, m, n, R 1 y R 2 son como se describen en el presente documento, composiciones que incluyen los compuestos, procesos de fabricación de los compuestos, métodos de uso de los compuestos y métodos para determinar la actividad inhibidora de monoacilglicerol lipasa (MAGL) de los compuestos
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公开(公告)号：CR20190268A
公开(公告)日：2019-07-11
申请号：CR20190268
申请日：2017-12-07
Applicant: HOFFMANN LA ROCHE
Inventor： GROEBKE-ZBINDEN KATRIN , KOBLET ANDREAS , BUETTELMANN BERND , FASCHING BERNHARD , PINARD EMMANUEL , CECERE GIUSEPPE , KNUST HENNER , THOMAS ANDREW , HERNANDEZ MARIA CLEMENCIA
IPC: A61K31/501 , A61K31/4439 , A61P25/28 , C07D413/14
Abstract: La invención proporciona compuestos novedosos que tienen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, X, Y y Z es tal como se describe en el presente documento, composiciones que incluye los compuestos y métodos de uso de los compuestos.The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：AU2006239329B2
公开(公告)日：2012-11-08
申请号：AU2006239329
申请日：2006-04-24
Applicant: HOFFMANN LA ROCHE
Inventor： HAAP WOLFGANG , PANDAY NARENDRA , HILPERT HANS , WIRZ BEAT , RICKLIN FABIENNE , GROEBKE-ZBINDEN KATRIN
IPC: C07D409/14 , A61K31/4025 , A61P7/02 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D413/14 , C07D513/04
Abstract: The invention is concerned with novel cyclic amines of formula (I) wherein X to X, Y to Y, R , R and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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