公开(公告)号：WO2013049776A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/058197

申请日：2012-09-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： FREUDENTHAL, Jacob K. ,  MARKS, Jeffrey A. ,  CHENG, Francis T. ,  WESSEL, Thomas

IPC: G06T5/00 ,  G06T5/50

CPC classification number: G06T7/0012 ,  G06T5/008 ,  G06T5/50 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/10144 ,  G06T2207/20021 ,  G06T2207/20216 ,  G06T2207/30072

Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.

Abstract translation: 提供了一种用于校准生物仪器的方法。 该方法包括以下步骤：获取至少一个生物样本阵列的图像，确定图像内的第一感兴趣区域，其中所述第一感兴趣区域包括所述至少一个生物阵列上的第一多个位置; 以及在所述第一感兴趣区域内识别与所述至少一个生物阵列上的所述第一多个位置中的每一个相关联的多个图像元素。

公开(公告)号：WO2013049702A9

公开(公告)日：2013-04-04

申请号：PCT/US2012/058096

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： FREUDENTHAL, Jacob K. ,  DAHLHOFF, Geoffrey ,  MAHER, Kevin ,  CHEN, Mingsong ,  LIM, Gary ,  DANEHY, Ronald ,  FORTESCUE, David ,  SHEN, Ming ,  SOH, Woon Liang Terence ,  CHENG, Francis ,  WU, Ruoyun ,  LEE, Thiam Chye ,  CHAPPELL, Gary ,  LIM, Chee Kiong ,  DERE, Jeff ,  STRAUB, Ted ,  FONSECA, Jorge ,  BOO, Kuan Moon ,  LAU, Soo Yong

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

公开(公告)号：EP2761585B1

公开(公告)日：2019-08-07

申请号：EP12784376.1

申请日：2012-09-30

Applicant: Life Technologies Corporation

Inventor： FREUDENTHAL, Jacob K. ,  MARKS, Jeffrey A. ,  CHENG, Francis T. ,  WESSEL, Thomas

IPC: G06T5/00 ,  G06T5/50

公开(公告)号：EP2761585A1

公开(公告)日：2014-08-06

申请号：EP12784376.1

申请日：2012-09-30

Applicant: Life Technologies Corporation

Inventor： FREUDENTHAL, Jacob K. ,  MARKS, Jeffrey A. ,  CHENG, Francis T. ,  WESSEL, Thomas

IPC: G06T5/00 ,  G06T5/50

CPC classification number: G06T7/0012 ,  G06T5/008 ,  G06T5/50 ,  G06T2207/10024 ,  G06T2207/10064 ,  G06T2207/10144 ,  G06T2207/20021 ,  G06T2207/20216 ,  G06T2207/30072

Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.

Abstract translation: 提供了一种用于校准生物仪器的方法。 该方法包括以下步骤：获取至少一个生物样本阵列的图像，确定图像内的第一感兴趣区域，其中所述第一感兴趣区域包括所述至少一个生物阵列上的第一多个位置; 以及在所述第一感兴趣区域内识别与所述至少一个生物阵列上的所述第一多个位置中的每一个相关联的多个图像元素。

公开(公告)号：EP2760585A2

公开(公告)日：2014-08-06

申请号：EP12784373.8

申请日：2012-09-28

Applicant: Life Technologies Corporation

Inventor： FREUDENTHAL, Jacob K. ,  DAHLHOFF, Geoffrey ,  MAHER, Kevin ,  CHEN, Mingsong ,  LIM, Gary ,  DANEHY, Ronald ,  FORTESCUE, David ,  SHEN, Ming ,  SOH, Woon Liang Terence ,  CHENG, Francis ,  WU, Ruoyun ,  LEE, Thiam Chye ,  CHAPPELL, Gary ,  LIM, Chee Kiong ,  DERE, Jeff ,  STRAUB, Ted ,  FONSECA, Jorge ,  BOO, Kuan Moon ,  LAU, Soo Yong

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: C12Q1/686 ,  B01L3/50855 ,  B01L3/50857 ,  B01L7/52 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.

Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件，每个样本保持器被配置为接收多个样本。 该系统还包括配置成使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。