公开(公告)号：NZ606259A

公开(公告)日：2014-06-27

申请号：NZ60625906

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： ROBINSON DANIEL ,  BINCH HAYLEY ,  DAVIS CHRIS ,  MILLER ANDREW ,  RUTHERFORD ALISTAIR ,  EVERITT SIMON ,  O’DONNELL MICHAEL ,  FRAYSSE DAMIEN ,  PINDER JOANNE ,  STUDLEY JOHN ,  BOYALL DEAN ,  MORTIMORE MICHAEL ,  RAMAYA SHARN

IPC: A01N57/00 ,  A01N43/54 ,  A61K31/66

Abstract: Disclosed is N-(5-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(3-cyclopropyl-3-fluoroazetidin-2-yl)pyrimidin-2-ylthio)pyridin-2-yl)-3,3,3- trifluoropropanamide represented by structural formula (I-21) or a pharmaceutically acceptable salt thereof, which inhibit Aurora protein kinase activity and are suitable for treating a proliferative disorder is selected from melanoma, myeloma, leukemia, lymphoma, neuroblastoma, or a cancer selected from colon, breast, gastric, ovarian, cervical, lung, central nervous system, renal, prostate, bladder, pancreatic, brain, head and neck, kidney, liver, melanoma, sarcoma, or thyroid cancer.

公开(公告)号：HK1259148A1

公开(公告)日：2019-11-29

申请号：HK19101173

申请日：2019-01-23

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  MORTIMORE MICHAEL ,  O’DONNELL MICHAEL ,  PINDER JOANNE ,  RUTHERFORD ALISTAIR ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  REAPER PHILIP MICHAEL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：NZ606263A

公开(公告)日：2014-03-28

申请号：NZ60626312

申请日：2006-11-03

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  MORTIMORE MICHAEL ,  FRAYSSE DAMIEN ,  DAVIS CHRIS ,  O’DONNELL MICHAEL ,  BOYALL DEAN ,  EVERITT SIMON ,  ROBINSON DANIEL ,  RAMAYA SHARN ,  STUDLEY JOHN ,  MILLER ANDREW ,  RUTHERFORD ALISTAIR ,  PINDER JOANNE

IPC: C07D239/02 ,  A61K31/4155 ,  C07D403/14

Abstract: 606263 Disclosed herein is a compound of formula I-24, and the use thereof in the treatment of a

公开(公告)号：NZ603477A

公开(公告)日：2014-09-26

申请号：NZ60347711

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： STORCK PIERRE-HENRI ,  KAY DAVID ,  BINCH HAYLEY MARIE ,  FANNING LEV TYLER DEWEY ,  REAPER PHILIP MICHAEL ,  CHARRIER JEAN-DAMIEN ,  YOUNG STEPHEN CLINTON ,  HURLEY DENNIS JAMES ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  JOSHI PRAMOD ,  O’DONNELL MICHAEL ,  CLEVELAND THOMAS ,  VIRANI ANISA NIZARALI ,  GROTE MATTHEW PAUL ,  PINDER JOANNE ,  DURRANT STEVEN JOHN

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: The disclosure relates to pyrazine and pyridine derivatives of formula (I), wherein the variables are as defined in the specification. These compounds are useful as inhibitors of ATR protein kinase involved in cellular responses to DNA damage, and are suitable for treating various diseases, disorders, and conditions that are mediated by the particular protein kinase, particularly suitable for treating cancer selected from lung cancer, head and neck cancer, pancreatic cancer, gastric cancer, and brain cancer. Processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors are also disclosed.