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1.发明申请HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN 审中-公开用于治疗疼痛的钠或钙通道阻断剂的异喹啉基苯基衍生物
公开(公告)号：WO2005013914A8
公开(公告)日：2006-09-28
申请号：PCT/US2004025827
申请日：2004-08-09
Applicant: VERTEX PHARMA , GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
Inventor： GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: C07C311/46 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
Abstract translation: 本发明涉及电压门控钠通道抑制剂的式（I-A）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。
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2.发明申请HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN 审中-公开用于治疗疼痛的钠或钙通道阻断剂的异喹啉基苯基衍生物
公开(公告)号：WO2005013914A3
公开(公告)日：2005-07-21
申请号：PCT/US2004025827
申请日：2004-08-09
Applicant: VERTEX PHARMA , GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
Inventor： GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04 , C07C311/44
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
Abstract translation: 本发明涉及电压门控钠通道抑制剂的式（I-A）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。
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公开(公告)号：CA2539227A1
公开(公告)日：2005-02-17
申请号：CA2539227
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE , TERMIN ANDREAS P , GONZALES JESUS E III
IPC: C07D285/12 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/44 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
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公开(公告)号：ZA200805338B
公开(公告)日：2010-03-31
申请号：ZA200805338
申请日：2006-12-21
Applicant: VERTEX PHARMA
Inventor： WILSON DEAN , FANNING LEV T D , SHETH URVI , MARTINBOROUGH ESTHER , TERMIN ANDREAS , NEUBERT TIMOTHY , ZIMMERMAN NICOLE , KNOLL TARA , WHITNEY TARA , KAWATKAR AARTI , LEHSTEN DANIELLE , STAMOS DEAN , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , GUTIERREZ COREY
IPC: A61K20100101 , A61P20100101 , C07D20100101
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：PE20050358A1
公开(公告)日：2005-05-16
申请号：PE2004000774
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , MARTINBOROUGH ESTHER , GONZALEZ III JESUS E , ZIMMERMAN NICOLE
IPC: A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04 , A61K7/00
Abstract: REFERIDA A UN COMPUESTO DE FORMULA I-A DONDE RN ES H, C1-C4 ALIIFATICO OPCIONALMENTE SUSTITUIDO; X1 ES O, S O NRX; X2 ES C1-C3 ALIFATICO OPCIONALMENTE SUSTITUIDO; p ES 0-1; Z ES i, ii, ENTRE OTROS; T ES ANILLO BICICLICO O TRICICLICO, AROMATICO O NO, DE 8-14 MIEMBROS TAL COMO NAFTILO, TETRALINA, O DECALINA. SON COMPUESTOS PREFERIDOS: 4-(2,4-DICLOROFENOXI)-BUTIRATO DE ETILO; 5,7-DICLORO-INDOL-2-IL-N-[4-(TIADIAZOL-2-ILSULFAMOIL)-FENIL]AMIDA Y N-[4-(TIAZOL-2-ILSULFAMOIL)-FENIL]-2-(4-FLUOROFENOXI)-ACETAMIDA; ENTRE OTROS. TAMBIEN REFERIDO A COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS QUE SON UTILES PARA EL TRATAMIENTO DE DOLORES NEUROPATICOS E INTRATABLES
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Patent Agency Ranking
公开(公告)号：CA2554566A1
公开(公告)日：2005-02-17
申请号：CA2554566
申请日：2004-08-05
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , NEUBERT TIMOTHY D , WILSON DEAN M , WANG JIAN , ZHANG YULIAN , ZIMMERMAN NICOLE , MARTINBOROUGH ESTHER , GONZALES JESUS E III
IPC: C07D239/94 , A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
Abstract: The present invention relates to compounds of formula (I) useful as inhibito rs of voltage-gated sodium channels. The invention also provides pharmaceutical ly acceptable compositions comprising the compounds of the invention and method s of using the compositions in the treatment of various disorders. Wherein R1, R2, X1-X4, P, and ring A are as defined in the present application.
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公开(公告)号：NZ545710A
公开(公告)日：2010-02-26
申请号：NZ54571004
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： GONZALES JESUS E , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: C07D285/12 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/44 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: Compounds of formula I, wherein the substituents are as defined in the specification, are useful for inhibiting sodium and calcium channels, and for treating acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epileptic conditions, neurodegenerative disorders, psychiatric disorders, anxiety, depression, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, and cancer pain. Novel compounds of formula I-A are also disclosed.
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公开(公告)号：PE03552005A1
公开(公告)日：2005-05-16
申请号：PE0007612004
申请日：2004-08-05
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , ZHANG YULIAN , GONZALEZ III JESUS E , ZIMMERMAN NICOLE , WANG JIAN , WILSON DEAN M , NEUBERT TIMOTHY D , MARTINBOROUGH ESTHER
IPC: A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
CPC classification number: C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
Abstract: REFERIDA A UN COMPUESTO DE FORMULA I O A UNA DE SUS SALES DONDE p ES 0-2; X1, X2, X3 Y X4 SON CADA UNO C=O, S, O, ENTRE OTROS; R1 Y R2 SON CADA UNO, H, UN GRUPO ALIFATICO C1-C6; ARILO DE 5-6 MIEMBROS, ENTRE OTROS; A ES ANILLO MONOCICLICO DE 5-6 MIEMBROS O BICICLICO DE 8-10 MIEMBROS, ANILLO SATURADO DE 3-7 MIEMBROS, ENTRE OTROS. ADICIONALMENTE, ESTOS COMPUESTOS RESULTANTES QUE SON UTILES COMO INHIBIDORES DE LOS CANALES DE SODIO REGULADOS POR VOLTAJE FORMAN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE DOLOR AGUDO, ARTRITIS, EPILEPSIA, ENTRE OTROS
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公开(公告)号：AU2004263179A1
公开(公告)日：2005-02-17
申请号：AU2004263179
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： GONZALES JESUS E III , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE , TERMIN ANDREAS P
IPC: C07D285/12 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/44 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：NZ579370A
公开(公告)日：2011-06-30
申请号：NZ57937004
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： GONZALES JESUS E , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: C07D277/52 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/44 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: Disclosed are compounds of formula III, wherein the substituents are as defined in the specification, their properties as inhibitors of voltage-gated sodium or calcium channel blockers and their utility in the treatment of pain. Also disclosed is a broader class of voltage-gated sodium/calcium channel blockers having formula T-L1-A-L2-Z wherein the substituents are as defined in the specification. (62) Divided Out of 545710
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