公开(公告)号：US11840446B2

公开(公告)日：2023-12-12

申请号：US16908666

申请日：2020-06-22

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Swaminathan Rajaraman ,  Charles Didier ,  Avra Kundu

IPC: B81C1/00 ,  B81B1/00 ,  C12M1/34 ,  G01N33/50

CPC classification number: B81C1/00111 ,  B81B1/008 ,  C12M41/46 ,  G01N33/5082 ,  B81B2201/055 ,  B81C2201/0146

Abstract: Disclosed herein is a microelectrode platform that may be used for multiple biosystem applications including cell culturing techniques and biosensing. Also disclosed are microfabrication techniques for inexpensively producing microelectrode platforms.

公开(公告)号：US11712549B2

公开(公告)日：2023-08-01

申请号：US16456695

申请日：2019-06-28

Applicant: Kinneret Rand

Inventor： Kinneret Rand

IPC: A61M37/00 ,  B33Y80/00

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B33Y80/00 ,  B81B2201/055 ,  B81B2201/057

Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.

公开(公告)号：US20180221635A1

公开(公告)日：2018-08-09

申请号：US15748184

申请日：2016-07-29

Applicant: OSONG MEDICAL INNOVATION FOUNDATION

Inventor： Jin-Hee MOON ,  In-Ho SONG ,  Jin-Won KIM ,  Seung-A LEE ,  Ha-Chul JUNG ,  Jin-Won AHN ,  Sang-Hun LEE ,  A-Hee KIM

IPC: A61M37/00 ,  A61M31/00 ,  A61N1/05 ,  B81B1/00 ,  B81C1/00

CPC classification number: A61M37/00 ,  A61M31/002 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2205/04 ,  A61M2205/054 ,  A61M2207/00 ,  A61N1/05 ,  B81B1/00 ,  B81B1/008 ,  B81B3/00 ,  B81B7/02 ,  B81B2201/055 ,  B81B2203/0338 ,  B81C1/00 ,  B81C1/00111 ,  B81C3/00

Abstract: In an implantable hybrid lead and a method of manufacturing the implantable hybrid lead, the implantable hybrid lead includes a conduit, a line electrode and a plurality of electrode terminals. The conduit has a fine channel through which a medicine is injected. The line electrode is inserted to and is combined with an outside of the conduit, and applies electrical simulation to a selected portion of a living body. A plurality of electrode terminals is disposed at an end of the conduit by a predetermined distance.

公开(公告)号：US20180200157A1

公开(公告)日：2018-07-19

申请号：US15744768

申请日：2016-07-13

Applicant: JUVIC INC.

Inventor： Hyung Il JUNG ,  Hui Suk YANG

IPC: A61K8/02 ,  A61K8/67 ,  A61K8/73 ,  A61K8/49 ,  A61Q19/02 ,  B81B1/00 ,  B81C1/00

CPC classification number: A61K8/0204 ,  A61K8/498 ,  A61K8/676 ,  A61K8/735 ,  A61K9/0021 ,  A61Q19/02 ,  B81B1/008 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention relates to a method of manufacturing a microstructure, including: (a) forming a solid on a substrate; (b) fluidizing the solid by adding a solvent thereto; and (c) shaping the fluidized solid, and a microstructure manufactured using the method.

公开(公告)号：US09919916B2

公开(公告)日：2018-03-20

申请号：US15031957

申请日：2014-10-15

Applicant: Semitechnologies Limited

Inventor： Yufei Lui ,  Owen Guy

IPC: B44C1/22 ,  C25F3/00 ,  B81C1/00 ,  A61M37/00 ,  C23C16/40

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  B81C2201/0176 ,  B81C2201/0181 ,  C23C16/402

Abstract: A method of forming microneedles where through a series of coating and etching processes microneedles are formed from a surface as an array. The microneedles have a bevelled end and bore which are formed as part of the process with no need to use a post manufacturing process to finish the microneedle.

公开(公告)号：US09595479B2

公开(公告)日：2017-03-14

申请号：US14218633

申请日：2014-03-18

Applicant: MCube, Inc.

Inventor： Xiao (Charles) Yang

IPC: H01L31/036 ,  H01L21/8238 ,  G01L9/00 ,  H01L21/762 ,  H01L27/06 ,  H03H3/007 ,  G01P15/125 ,  G01P15/08 ,  H01L21/822 ,  B81C1/00 ,  H01L29/04 ,  H01L25/065 ,  A61B5/145

CPC classification number: H01L21/823878 ,  A61B5/14514 ,  B81B2201/025 ,  B81B2201/055 ,  B81C1/00246 ,  G01L9/0042 ,  G01L9/0054 ,  G01P15/0802 ,  G01P15/125 ,  H01L21/76254 ,  H01L21/8221 ,  H01L25/0657 ,  H01L27/0688 ,  H01L29/045 ,  H01L2924/0002 ,  H03H3/0073 ,  H01L2924/00

Abstract: A method for fabricating a three-dimensional integrated circuit device includes providing a first substrate having a first crystal orientation, forming at least one or more PMOS devices overlying the first substrate, and forming a first dielectric layer overlying the one or more PMOS devices. The method also includes providing a second substrate having a second crystal orientation, forming at least one or more NMOS devices overlying the second substrate, and forming a second dielectric layer overlying the one or more NMOS devices. The method further includes coupling the first dielectric layer to the second dielectric layer to form a hybrid structure including the first substrate overlying the second substrate.

Abstract translation: 一种制造三维集成电路器件的方法包括提供具有第一晶体取向的第一衬底，形成覆盖在第一衬底上的至少一个或多个PMOS器件，以及形成覆盖该一个或多个PMOS器件的第一介电层。 该方法还包括提供具有第二晶体取向的第二衬底，形成覆盖第二衬底的至少一个或多个NMOS器件，以及形成覆盖该一个或多个NMOS器件的第二电介质层。 该方法还包括将第一电介质层耦合到第二电介质层以形成包括覆盖在第二衬底上的第一衬底的混合结构。

公开(公告)号：US09561356B2

公开(公告)日：2017-02-07

申请号：US14988769

申请日：2016-01-06

Applicant: Debiotech S.A.

Inventor： Astrid Cachemaille ,  François Cannehan

IPC: C25F3/00 ,  B44C1/22 ,  C03C15/00 ,  A61M37/00 ,  B81C1/00

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  Y10T29/49826 ,  Y10T428/24479

Abstract: Out-of-plane microneedle manufacturing process comprising the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat (2) above each microneedle (1) under formation, said process comprising the following steps: providing bridges (3) between the hats (3), maintaining the bridges (3) during the remaining microneedle manufacturing steps, removing the bridges (3), together with the hats (2), when the microneedles (1) are formed.

Abstract translation: 面外微型制造工艺包括同时创建微针网络并在形成每个微针（1）上方形成多边形帽（2），所述方法包括以下步骤：提供桥 （3），在剩余的微针制造步骤期间保持桥（3），当形成微针（1）时，与帽子（2）一起移除桥（3）。

公开(公告)号：US20160264408A1

公开(公告)日：2016-09-15

申请号：US15031957

申请日：2014-10-15

Applicant: Swansea University

Inventor： Yufei LUI ,  Owen GUY

IPC: B81C1/00 ,  A61M37/00

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C2201/0132 ,  B81C2201/0133 ,  B81C2201/0159 ,  B81C2201/0176 ,  B81C2201/0181 ,  C23C16/402

Abstract: A method of forming microneedles where through a series of coating and etching processes microneedles are formed from a surface as an array. The microneedles have a bevelled end and bore which are formed as part of the process with no need to use a post manufacturing process to finish the microneedle.

Abstract translation: 一种形成微针的方法，其中通过一系列涂层和蚀刻处理微针从表面形成为阵列。 微针具有倾斜的端部和孔，其形成为该过程的一部分，而不需要使用后制造工艺来完成微针。

公开(公告)号：US20160220803A1

公开(公告)日：2016-08-04

申请号：US15010734

申请日：2016-01-29

Applicant: The University of Queensland

Inventor： Mark Anthony Fernance KENDALL ,  Derek William Kenneth JENKINS

IPC: A61M37/00 ,  A61K9/00 ,  H01J37/32

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61K9/0097 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  H01J37/32009 ,  H01J37/3244 ,  H01J2237/334

Abstract: A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen.

公开(公告)号：US20160129232A1

公开(公告)日：2016-05-12

申请号：US14988769

申请日：2016-01-06

Applicant: Debiotech S.A.

Inventor： Astrid Cachemaille ,  François Cannehan

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  Y10T29/49826 ,  Y10T428/24479

Abstract: Out-of-plane microneedle manufacturing process comprising the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat (2) above each microneedle (1) under formation, said process comprising the following steps: providing bridges (3) between the hats (3), maintaining the bridges (3) during the remaining microneedle manufacturing steps, removing the bridges (3), together with the hats (2), when the microneedles (1) are formed.

Abstract translation: 面外微型制造工艺包括同时创建微针网络并在形成每个微针（1）上方形成多边形帽（2），所述方法包括以下步骤：提供桥 （3），在剩余的微针制造步骤期间保持桥（3），当形成微针（1）时，与帽子（2）一起移除桥（3）。