公开(公告)号：US06687001B2

公开(公告)日：2004-02-03

申请号：US09938483

申请日：2001-08-27

Applicant: Takeo Iwama

Inventor： Takeo Iwama

IPC: G01J328

CPC classification number: G01J9/0246 ,  G01J3/1256 ,  G01J3/2803

Abstract: In an optical spectrum analyzer comprising a spectrograph and a photodevice array, and an optical spectrum detecting method, a wavelength deviation, from an assigned wavelength, of a light detected by a photodevice array which detects a wavelength of a diffraction light or a non-diffraction light from an acoustooptic device, is detected and a feedback control to a diffraction angle of the acoustooptic device is performed. Also, without using a feedback control, an exit light and a diffraction light from the acoustooptic device are respectively received by two photodevice arrays and the photodevices are arranged in order to mutually compensate gaps between the photodevices, whereby a center of each photodevice is similarly made coincide with a peak of an optical beam to be received.

Abstract translation: 在包括光谱仪和光器件阵列以及光谱检测方法的光谱分析仪中，从检测衍射光的波长的光器件阵列检测到的光的波长偏差，或非衍射 检测来自声光装置的光，并执行对声光装置的衍射角的反馈控制。 此外，不使用反馈控制，来自声光装置的出射光和衍射光分别由两个光器件阵列接收，并且设置光器件以相互补偿光器件之间的间隙，由此类似地制造每个光器件的中心 与待接收的光束的峰值一致。

公开(公告)号：US20020176125A1

公开(公告)日：2002-11-28

申请号：US10200183

申请日：2002-07-23

Applicant: Proximion Fiber Optics AB.

Inventor： Adel Asseh ,  Mikael Bergman ,  Bengt Sahlgren ,  Simon Sandgren ,  Raoul Stubbe

IPC: G02F001/01

CPC classification number: G01J3/1256 ,  G02F1/125 ,  G02F2201/307

Abstract: A method of establishing transmission of light through a chirped Bragg-reflector, a method of analyzing the power spectrum of a light signal using a chirped Bragg-reflector, and an arrangement for analyzing the power spectrum of a light signal. The Bragg-reflector reflects, in an unperturbed state, essentially all incident light within a predefined wavelength range. The methods include the steps of directing the light to be analyzed into an input end of a light-guiding structure, such as an optical fiber, which light-guiding structure is provided with a Bragg-reflector, and sending an acoustic pulse along the light-guiding structure, thereby effectively lowering the reflectance of the Bragg-reflector for a certain wavelength at a certain time. By monitoring the light thus transmitted through the Bragg-reflector, a power spectrum analysis of the incident light is obtained.

Abstract translation: 通过啁啾布拉格反射器建立光的透射的方法，使用啁啾布拉格反射器分析光信号的功率谱的方法以及用于分析光信号的功率谱的装置。 在无扰动状态下，布拉格反射器基本上反射了预定波长范围内的所有入射光。 这些方法包括以下步骤：将待分析的光引导到诸如光纤的光导结构的输入端，光导结构设置有布拉格反射器，并沿着光发送声脉冲 导向结构，从而在一定时间内有效地降低了布拉格反射器对某一波长的反射率。 通过监测通过布拉格反射器传输的光，可以获得入射光的功率谱分析。

公开(公告)号：US5991028A

公开(公告)日：1999-11-23

申请号：US824234

申请日：1997-03-25

Applicant: Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Nissim Ben-Yosef

Inventor： Dario Cabib ,  Robert A. Buckwald ,  Zvi Malik ,  Nissim Ben-Yosef

IPC: G01B9/02 ,  C12N5/06 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01J5/10 ,  G01N15/14 ,  G01N21/27 ,  G01N21/64 ,  G01N33/48 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76

CPC classification number: C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01J5/10 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6417

Abstract: According to the present invention there is provided a spectral bio-imaging methods which can be used for automatic and/or semiautomatic spectrally resolved morphometric classification of cells, the method comprising the steps of (a) preparing a sample to be spectrally imaged, the sample including at least a portion of at least one cell; (b) viewing the sample through an optical device, the optical device being optically connected to an imaging spectrometer, the optical device and the imaging spectrometer being for obtaining a spectrum of each pixel of the sample; (c) classifying each of the pixels into classification groups according to the pixels spectra; and (d) analyzing the classification groups and thereby classifying the at least one cell into a cell class.

Abstract translation: 根据本发明，提供了可用于细胞的自动和/或半自动光谱解析形态学分类的光谱生物成像方法，该方法包括以下步骤：（a）制备待光谱成像的样品，样品 包括至少一个细胞的至少一部分; （b）通过光学装置观察样品，光学装置光学连接到成像光谱仪，光学装置和成像光谱仪用于获得样品的每个像素的光谱; （c）根据像素光谱将每个像素分类成分类组; 和（d）分析分类组，从而将至少一个细胞分类成细胞类别。

公开(公告)号：US5828451A

公开(公告)日：1998-10-27

申请号：US940543

申请日：1997-09-30

Applicant: Peter A. Bellus ,  Dennis R. Suhre

Inventor： Peter A. Bellus ,  Dennis R. Suhre

IPC: G01J3/12 ,  G01J3/28

CPC classification number: G01J3/1256 ,  G01J3/2823

Abstract: An acousto-optic tunable filter (AOTF) has one or more optical wavelength passbands dependent on the frequency or frequencies of a radio frequency signal applied thereto. A radio frequency generator applies the radio frequency signal under computer control of the RF frequency so that the radio frequency signal has one or more preselected frequency components. An input optics system directs incident object or scene light to the AOTF. A first polarizing element passes to the AOTF only image light which is polarized in a first direction. A second polarizing element receives output image light from the AOTF and passes only image light which is polarized in a direction orthogonal to the first direction. The image light passed by the second polarizing element is detected by a camera. An output optics system focusses image light passed by the second polarizer on an image plane of the camera, and an image corresponding to the detected image light is recorded. An image processor receives recorded image data for processing.

Abstract translation: 声光可调谐滤波器（AOTF）具有取决于施加到其上的射频信号的频率或频率的一个或多个光学波长通带。 无线电频率发生器在RF频率的计算机控制下施加射频信号，使得射频信号具有一个或多个预选频率分量。 输入光学系统将入射物体或场景光引导到AOTF。 第一偏振元件传递到仅在第一方向上偏振的仅AOTF图像光。 第二偏振元件从AOTF接收输出图像光，并且仅通过在与第一方向正交的方向上偏振的图像光。 由第二偏振元件通过的图像光由相机检测。 输出光学系统将通过第二偏振器的图像光聚焦在相机的图像平面上，并且记录与检测到的图像光对应的图像。 图像处理器接收用于处理的记录图像数据。

公开(公告)号：US5798262A

公开(公告)日：1998-08-25

申请号：US844516

申请日：1997-04-18

Applicant: Yuval Garini ,  Nir Katzir ,  David Wine ,  Dario Cabib

Inventor： Yuval Garini ,  Nir Katzir ,  David Wine ,  Dario Cabib

IPC: G01N33/48 ,  C12M1/00 ,  C12M3/00 ,  C12N15/09 ,  C12N15/11 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/28 ,  G01N21/64 ,  G01N21/75 ,  G01N33/483 ,  G01N33/50 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58 ,  G01N37/00 ,  G02B21/00 ,  G02B21/16 ,  G06K9/00 ,  G06K9/76 ,  C12M1/34 ,  G06F15/00

CPC classification number: G01J3/12 ,  C12Q1/6816 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/582 ,  G06K9/00127 ,  G06K9/0014 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6423 ,  G01N2021/6441

Abstract: A method for finding L internal reference vectors for classification of L chromosomes or portions of chromosomes of a cell, the L chromosomes or portions of chromosomes being painted with K different fluorophores or combinations thereof, wherein K basic chromosomes or portions of chromosomes of the L chromosomes or portions of chromosomes are each painted with only one of the K different fluorophores, whereas the other L-K of the L chromosomes or portions of chromosomes are each painted with a different combination of the K different fluorophores, the method comprising the steps of (a) using a multi-band collection device for measuring a first vector for each pixel of each of the L chromosomes or portions of chromosomes; (b) identifying pixels belonging to each of the K basic chromosomes or portions of chromosomes and defining the pixels as basic pixels, so as to obtain K basic classes of basic pixels; (c) using at least one basic pixel from each of the K basic classes for obtaining K basic vectors, the K basic vectors being K internal reference vectors; (d) using the K basic vectors for identifying pixels belonging to the other L-K chromosomes or portions of chromosomes; and (e) using the pixels belonging to the other L-K chromosomes or portions of chromosomes for calculating the other L-K internal reference vectors, thereby finding all of the L internal reference vectors. A method for classification of L chromosomes or portions of chromosomes of a cell similarly painted using the above method for finding L internal reference vectors, and using the L reference vectors for classification of each of the pixels into one of L classification classes. And, images presenting color chromosomes.

公开(公告)号：US5796512A

公开(公告)日：1998-08-18

申请号：US603035

申请日：1996-02-16

Applicant: Elliot S. Wachman ,  Daniel L. Farkas ,  Wen-Hua Niu

Inventor： Elliot S. Wachman ,  Daniel L. Farkas ,  Wen-Hua Niu

IPC: G01J3/12 ,  G01J3/28 ,  G02F1/33

CPC classification number: G01J3/1256 ,  G01J3/2823

Abstract: An imaging system comprises an acousto-optic tunable filter for receiving light at an input end thereof and outputting light at an output end thereof. A control circuit is provided for tuning the filter. A prism is responsive to the light output by the tunable filter. The prism is oriented at an angle with respect to the filter to compensate for dispersion of the output light caused by the tunable filter.

Abstract translation: 成像系统包括用于在其输入端接收光并在其输出端输出光的声光可调滤波器。 提供用于调谐滤波器的控制电路。 棱镜响应于可调谐滤光器的光输出。 棱镜相对于滤光片定向成一定角度，以补偿由可调谐滤光器引起的输出光的色散。

公开(公告)号：US5539517A

公开(公告)日：1996-07-23

申请号：US392019

申请日：1995-02-21

Applicant: Dario Cabib ,  Zvi Friedman ,  Stephen G. Lipson ,  Robert A. Buckwald

Inventor： Dario Cabib ,  Zvi Friedman ,  Stephen G. Lipson ,  Robert A. Buckwald

IPC: C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

CPC classification number: G01N21/6456 ,  C12Q1/6883 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/6428 ,  G06K9/00127 ,  G06K9/76 ,  G01J2003/2866 ,  G01J3/02 ,  G01N2021/6423

Abstract: A method of analyzing an optical image of a scene to determine the spectral intensity of each pixel of the scene, which includes collecting incident light from the scene; (b) passing the light through an interferometer which outputs modulated light corresponding to a predetermined set of linear combinations of the spectral intensity of the light emitted from each pixel; focusing the light outputted from the interferometer on a detector array; and processing the output of the detector array to determine the spectral intensity of each pixel thereof. If the interferometer is of the moving type scanning in one dimension is required where the detector array is one dimensional, and no scanning when the detector array is two-dimensional. If the interferometer is of the non-moving type scanning is required in one dimension when the detector array is two-dimensional, and in two dimensions when the detector array is one-dimensional.

Abstract translation: 一种分析场景的光学图像以确定场景的每个像素的光谱强度的方法，其包括从场景收集入射光; （b）使光通过干涉仪，该干涉仪输出对应于从每个像素发射的光的光谱强度的预定的一组线性组合的调制光; 将从干涉仪输出的光聚焦在检测器阵列上; 以及处理检测器阵列的输出以确定其每个像素的光谱强度。 如果在检测器阵列是一维的情况下需要扫描一维的干涉仪，而检测器阵列是二维的则不需要扫描。 如果当检测器阵列是二维的时，如果干涉仪是一个维度中的非移动型扫描，并且当检测器阵列是一维的时在二维中。

公开(公告)号：US5438406A

公开(公告)日：1995-08-01

申请号：US134188

申请日：1993-10-07

Applicant: Jeffrey J. Puschell

Inventor： Jeffrey J. Puschell

IPC: G01J3/12 ,  G01J3/36 ,  G01N31/35

CPC classification number: G01J3/1256

Abstract: Light from a discrete broadband visible and/or infrared light source is collimated and transmitted within an optical path that is open to an ambient environment through a spatial region of interest and is focused to a beam splitter, which splits the transmitted light into different beams and directs the different beams respectively to a pair of narrowband acousto-optical tunable filters (AOTF). One such AOTF is disposed for filtering one split transmitted light beam and is rapidly tuned through a predetermined series of different wavelengths that are characteristic of an energy absorption spectrum for a first given substance, or of a first predetermined set of given substances. The other AOTF is disposed for filtering the other split transmitted light beam and is rapidly tuned through a given substances. First and second detectors respectively detect the energy of the filtered transmitted light from the two AOTFs at each of the tuned wavelengths to provide simultaneous signals that are indicative of energy absorption spectra for the region of interest at wavelengths that are characteristic of the energy absorption spectra for the first and second given substances or for the first and second predetermined sets of given substances.

Abstract translation: 来自离散宽带可见光和/或红外光源的光在通过感兴趣的空间区域对周围环境开放的光路内进行准直和透射，并被聚焦到分束器，分束器将透射光分成不同的光束， 将不同的光束分别引导到一对窄带声光可调滤波器（AOTF）。 一个这样的AOTF被设置用于对一个分裂的透射光束进行滤波，并且通过预定的一系列不同的波长被快速调谐，这些不同的波长是第一给定物质或第一预定的给定物质的能量吸收光谱的特征。 另一个AOTF设置用于过滤其他分裂透射光束，并通过给定的物质快速调谐。 第一和第二检测器分别在每个调谐的波长处分别检测来自两个AOTF的滤波的透射光的能量，以提供同时的信号，其表示在对于在能量吸收光谱的特征的波长处的感兴趣区域的能量吸收光谱， 第一和第二给定物质或第一和第二预定组给定物质。

公开(公告)号：US5379065A

公开(公告)日：1995-01-03

申请号：US904550

申请日：1992-06-22

Applicant: James A. Cutts

Inventor： James A. Cutts

IPC: G01J3/12 ,  G01J3/28 ,  H04N5/353 ,  H04N5/372 ,  H04N9/04

CPC classification number: G01J3/2823 ,  G01J3/1256 ,  G01J3/2803 ,  H04N3/1543 ,  H04N3/155 ,  H04N9/045

Abstract: A hyperspectral imager includes a focal plane having an array of spaced image recording pixels receiving light from a scene moving relative to the focal plane in a longitudinal direction, the recording pixels being transportable at a controllable rate in the focal plane in the longitudinal direction, an electronic shutter for adjusting an exposure time of the focal plane, whereby recording pixels in an active area of the focal plane are removed therefrom and stored upon expiration of the exposure time, an electronic spectral filter for selecting a spectral band of light received by the focal plane from the scene during each exposure time and an electronic controller connected to the focal plane, to the electronic shutter and to the electronic spectral filter for controlling (a) the controllable rate at which the recording is transported in the longitudinal direction, (b) the exposure time and (c) the spectral band so as to record a selected portion of the scene through M spectral bands with a respective exposure time t.sub.q for each respective spectral band q.

Abstract translation: 高光谱成像器包括焦平面，该焦平面具有从纵向方向相对于焦平面移动的场景接收光的间隔图像记录像素的阵列，记录像素可在纵向方向上在焦平面中以可控速率传送， 用于调节焦平面的曝光时间的电子快门，由此在曝光时间到期时从焦点平面的活动区域中记录像素被移除并存储;电子光谱滤波器，用于选择由焦点接收的光的光谱带 （a）在纵向方向上传送记录的可控速率;（b）在每个曝光时间内从场景平面和连接到焦平面的电子控制器，电子快门和电子光谱滤波器，用于控制（a） 曝光时间和（c）光谱带，以便通过M个光谱带记录场景的选定部分 对于每个相应的光谱带q具有相应的曝光时间tq。

公开(公告)号：US4781425A

公开(公告)日：1988-11-01

申请号：US830457

申请日：1966-02-18

Applicant: William P. Risk ,  Gordon S. Kino

Inventor： William P. Risk ,  Gordon S. Kino

IPC: G01J3/02 ,  G01J3/12 ,  G01J3/447 ,  G01J9/00 ,  G02B6/10 ,  G02B6/34 ,  G02F1/01 ,  G02F1/11

CPC classification number: G02B6/29302 ,  G01J3/447 ,  G01J9/00 ,  G02B6/105 ,  G02F1/0134 ,  G01J3/1256 ,  G02B6/2713 ,  G02B6/274 ,  G02B6/2766

Abstract: An acousto-optic frequency shifter having a long interaction region is used as an optical analyzer. A variable frequency signal generator is used to drive an acoustic transducer to launch an acoustic wave in contact with an optical fiber. The acoustic frequency is varied over a known range to generate acoustic waves having known wavelengths. An optical signal having an unknown optical wavelength is introduced into one end of the optical fiber in a first polarization mode. The effect of the acoustic wave on the optical signal is to cause coupling of the optical signal from the first polarization mode to a second orthogonal polarization mode. The amount of the coupling is dependent upon the phase-matching between the acoustic wavelength and the optical beat length. The coupling between the polarization modes is maximum when the acoustic wavelength is equal to the optical beat length. The intensity of the optical signal coupled to the second polarization mode can be measured to determine the optical wavelength corresponding to the acoustic wavelength when the maximum intensity occurs.

Abstract translation: 使用具有长相互作用区域的声光移频器作为光学分析器。 可变频率信号发生器用于驱动声换能器以发射与光纤接触的声波。 声频在已知范围内变化以产生具有已知波长的声波。 具有未知光波长的光信号以第一偏振模式被引入光纤的一端。 声波对光信号的影响是使来自第一偏振模式的光信号耦合到第二正交偏振模式。 耦合的量取决于声波长和光学拍子长度之间的相位匹配。 当声波长等于光拍长度时，极化模式之间的耦合是最大的。 可以测量耦合到第二偏振模式的光信号的强度，以确定当发生最大强度时对应于声波长的光波长。