公开(公告)号：US20110133101A1

公开(公告)日：2011-06-09

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G01J1/58 ,  G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US07835601B2

公开(公告)日：2010-11-16

申请号：US11871389

申请日：2007-10-12

Applicant: Volker Seyfried ,  Rafael Storz

Inventor： Volker Seyfried ,  Rafael Storz

IPC: G02B6/28 ,  G02B6/36 ,  H01S3/30 ,  H01S3/10

CPC classification number: H01S3/02 ,  G01N21/6458 ,  G01N2201/024 ,  G02B21/0032 ,  H01S3/2383

Abstract: A device for generating a laser light beam includes a module. The module includes at least one laser light source, and a mechanical, an electrical and/or an optical interface defined towards an outside of the module.

Abstract translation: 用于产生激光束的装置包括模块。 该模块包括至少一个激光光源，以及朝向模块的外部限定的机械，电和/或光学接口。

公开(公告)号：US20090097806A1

公开(公告)日：2009-04-16

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US20080003142A1

公开(公告)日：2008-01-03

申请号：US11803104

申请日：2007-05-11

Applicant: Darren Link ,  Michael Weiner ,  David Marran ,  Jonathan Rothberg

Inventor： Darren Link ,  Michael Weiner ,  David Marran ,  Jonathan Rothberg

IPC: G01N21/64 ,  B01L3/00 ,  B29C33/38

CPC classification number: B01F3/0807 ,  B01F13/0062 ,  B01J19/0093 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/565 ,  B01L7/525 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0487 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  C12N15/1068 ,  C12N15/1086 ,  C12Q1/00 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2565/628 ,  C12Q2565/629 ,  G01N15/147 ,  G01N21/05 ,  G01N21/64 ,  G01N27/3275 ,  G01N35/08 ,  G01N2021/0346 ,  G01N2035/00237 ,  G01N2035/00326 ,  G01N2201/024 ,  Y10T137/87571 ,  Y10T137/87619 ,  Y10T137/87652 ,  C12Q2525/191 ,  C12Q2563/159 ,  C12Q2535/101 ,  C12Q2563/149 ,  C12Q2531/113

Abstract: The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

Abstract translation: 本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。 基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

公开(公告)号：US20070183931A1

公开(公告)日：2007-08-09

申请号：US11351181

申请日：2006-02-08

Applicant: Daniel Stock ,  Josef Atzler

Inventor： Daniel Stock ,  Josef Atzler

IPC: G01N21/00

CPC classification number: G01N21/645 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample is provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

Abstract translation: 提供了一种用于分析样品的装置中的盒和盒系统。 盒具有一个或多个光源和/或光学系统以及其它特定于某种类型的应用，如荧光，吸光度或发光的组件。 用于特定应用的光源，光学系统和其他部件容纳在单个盒中。 该系统具有用于多模仪器的不同应用的多个盒。 盒可以以“插入”格式可移除地与设备接合，使得一个盒可以从设备移除，并且另一个盒可以容易地安装。

公开(公告)号：US07230697B2

公开(公告)日：2007-06-12

申请号：US11040709

申请日：2005-01-20

Applicant: Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

Inventor： Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

IPC: G01J3/28

CPC classification number: G01N21/6458 ,  G01J3/0202 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/36 ,  G01N2021/6423 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/024 ,  G01N2201/10 ,  G01N2201/103 ,  G02B21/26

Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.

Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。

公开(公告)号：US07199879B2

公开(公告)日：2007-04-03

申请号：US10784997

申请日：2004-02-25

Applicant: Raimo Harju ,  Janne Salonen ,  Hannu Turunen

Inventor： Raimo Harju ,  Janne Salonen ,  Hannu Turunen

IPC: G01N21/25

CPC classification number: G01N21/763 ,  G01N21/6452 ,  G01N2201/024 ,  G02B6/0001

Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrument for photoluminescence, chemiluminescence and/or AlphaScreen measurements wherein different optical modules are used for alternative measurements. The excitation pulses for the alternative measurements are guided via two different routes to optical modules, the routes reaching the module in different angles. This way it is possible to use alternative radiation sources without optical switches and without changing the optical system. The object of the invention is further achieved by providing an additional lens in the optical module when a thermo plate is used. This way it is possible to achieve a correct optical focus in different measurement modes not depending on the use of the thermo plate.

Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供用于光致发光，化学发光和/或AlphaScreen测量的光学测量仪器来实现，其中不同的光学模块用于替代测量。 用于替代测量的激励脉冲通过两个不同的路由被引导到光学模块，这些路径以不同的角度到达模块。 这样就可以使用没有光开关的替代辐射源，而不改变光学系​​统。 当使用热板时，通过在光学模块中提供附加透镜来进一步实现本发明的目的。 通过这种方式，可以在不同于热板的使用的不同测量模式下实现正确的光学焦点。

公开(公告)号：US20050214863A1

公开(公告)日：2005-09-29

申请号：US11010816

申请日：2004-12-13

Applicant: John McDevitt ,  Eric Anslyn ,  Jason Shear ,  Dean Neikirk ,  Nick Christodoulides

Inventor： John McDevitt ,  Eric Anslyn ,  Jason Shear ,  Dean Neikirk ,  Nick Christodoulides

IPC: B01J19/00 ,  B01L3/00 ,  C40B40/10 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/53 ,  G01N33/543 ,  G01N33/544 ,  G01N33/552 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N33/5304 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487 ,  C40B40/10 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/77 ,  G01N33/54313 ,  G01N33/544 ,  G01N33/552 ,  G01N33/6887 ,  G01N33/92 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2201/024 ,  G01N2800/32 ,  Y10S436/807 ,  Y10S436/809

Abstract: A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

Abstract translation: 用于快速表征唾液中分析物的系统。 在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施方案中，一系列化学敏感性颗粒位于空腔内。 当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。 在一个实施例中，多个空腔的每个空腔被设计成捕获并容纳特定尺寸的颗粒。 可以将柔性突出部定位在每个空腔上，以提供颗粒在空腔中的保持。

公开(公告)号：US20050157294A1

公开(公告)日：2005-07-21

申请号：US11040709

申请日：2005-01-20

Applicant: Mark Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

Inventor： Mark Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

IPC: G01J3/04 ,  G01J3/10 ,  G01J3/28 ,  G01J3/30 ,  G01J3/36 ,  G01N21/64 ,  G02B21/26

CPC classification number: G01N21/6458 ,  G01J3/0202 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/36 ,  G01N2021/6423 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/024 ,  G01N2201/10 ,  G01N2201/103 ,  G02B21/26

Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.

Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。

公开(公告)号：US20050122519A1

公开(公告)日：2005-06-09

申请号：US10826257

申请日：2004-04-19

Applicant: Jau-Jiu Ju ,  Yuan-Chin Lee ,  K. C. Chin ,  Kuang-Wu Hsu ,  Chen-I Kuo ,  Hae-Ruoh Huang ,  Yueh-Hsuan Tsai

Inventor： Jau-Jiu Ju ,  Yuan-Chin Lee ,  K. C. Chin ,  Kuang-Wu Hsu ,  Chen-I Kuo ,  Hae-Ruoh Huang ,  Yueh-Hsuan Tsai

IPC: C12M1/00 ,  C12M1/34 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N21/645 ,  G01N2021/6471 ,  G01N2201/024

Abstract: A fluorescent auxiliary testing apparatus includes a light source module which emits a laser light to pass through a collimator, a dichroic mirror, and a first converging lens to project a testing object. The testing object emits a corresponding testing fluorescent light which passes through a filter assembly and a second converging lens and is received by a photo detector for generating a photoelectric signal. The photoelectric signal is transferred to a data processing equipment to perform test and analysis processes. The apparatus has a small size and a simple structure, and may be fabricated at a low cost.

Abstract translation: 荧光辅助测试装置包括发射激光以通过准直仪的光源模块，二向色镜和第一会聚透镜以投影测试对象。 测试对象发射相应的测试荧光，其通过过滤器组件和第二会聚透镜，并由光电检测器接收以产生光电信号。 光电信号被传送到数据处理设备进行测试和分析处理。 该装置具有小尺寸和简单的结构，并且可以以低成本制造。