公开(公告)号：US09535247B2

公开(公告)日：2017-01-03

申请号：US15166668

申请日：2016-05-27

Applicant: The Regents of the University of California

Inventor： Xiaodong Tao ,  Joel A. Kubby

IPC: G01N21/45 ,  G02B27/00 ,  G01N21/49 ,  G01N21/64 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36 ,  G01J9/00 ,  G02B27/09 ,  G01N21/47

CPC classification number: G02B27/0068 ,  G01J9/00 ,  G01N21/45 ,  G01N21/49 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/4709 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/121 ,  G02B21/16 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0927

Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

Abstract translation: 干涉测深（IF），而不是传统的几何聚焦，激发光到深埋在组织中的引导星，增加其荧光强度。 该方法可以延长波前测量的深度，并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的差异。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 虽然激励路径中只有弹道光被校正，波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。

公开(公告)号：US20160313241A1

公开(公告)日：2016-10-27

申请号：US15102769

申请日：2014-12-02

Applicant: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.

Inventor： Kazuhiro OCHI ,  Tatsuya TAKAHASHI

IPC: G01N21/359 ,  G01N33/02

CPC classification number: G01N21/359 ,  G01N33/02 ,  G01N2201/068 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/1214

Abstract: This calorie measurement device is provided with the following: a light-emission unit that exposes a food article to light that contains near-infrared wavelengths; a light-reception unit that receives transmitted light that had passed through the food article and/or reflected light that was reflected by the food article; a correction unit that computes a base absorbance for the food article on the basis of the transmitted and/or reflected light and corrects the light intensity measured by the light-reception unit and/or the computed base absorbance on the basis of affecting factors, said affecting factors being those that affect the absorption and reflection of light by the food article but are essentially unaffected by the light-absorption and light-reflection properties of the components of the food article; and an analysis unit that computes an analysis value indicating the caloric content of the food article on the basis of the corrected light intensity measured by the light-reception unit and/or the corrected base absorbance.

Abstract translation: 这种卡路里测量装置具有以下装置：将食品暴露于含有近红外波长的光的发光单元; 光接收单元，其接收通过食品的透射光和/或被食品反射的反射光; 校正单元，其基于透射和/或反射光计算食品的基本吸光度，并且基于影响因素校正由光接收单元测量的光强度和/或计算的基底吸光度，所述校正单元 影响因素是影响食品对光的吸收和反射的因素，但基本上不受食品的组分的光吸收和光反射性质的影响; 以及分析单元，其基于由光接收单元测量的校正光强度和/或校正的基本吸光度计算指示食品的热量含量的分析值。

公开(公告)号：US20160187363A1

公开(公告)日：2016-06-30

申请号：US14985679

申请日：2015-12-31

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Kui Hyun Kim ,  Sang Bum Park ,  Joo Hee Park

IPC: G01N35/00 ,  G01N21/77

CPC classification number: G01N21/77 ,  B01L3/5027 ,  B01L2200/0684 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0409 ,  G01N21/78 ,  G01N35/00069 ,  G01N35/00623 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2035/00346 ,  G01N2035/00851 ,  G01N2201/121

Abstract: Disclosed herein are a reactor, a test apparatus, and a test method, which measure, when a material included in a sample acts as an interfering material with respect to estimating a concentration of a target material, a concentration of the interfering material, and correct an estimated concentration of the target material based on the concentration of the interfering material, thereby improving the reliability and accuracy of the concentration of the target material. The reactor includes: a target material detecting chamber in which a first reagent that includes a first material that is activated by a target material is contained; a first material detecting chamber in which a second reagent that includes the target material is contained; an inlet hole into which a sample is injected; and a channel configured to connect the inlet hole, the target material detecting chamber, and the first material detecting chamber to each other.

Abstract translation: 本文公开了一种反应器，测试装置和测试方法，其当包含在样品中的材料在估计目标材料的浓度时作为干扰材料，测量干扰材料的浓度并校正 基于干扰材料的浓度的目标材料的估计浓度，从而提高目标材料的浓度的可靠性和精度。 所述反应器包括：目标材料检测室，其中包含第一试剂，所述第一试剂包含被靶材料活化的第一材料; 第一材料检测室，其中包含包含靶材料的第二试剂; 注入样品的入口孔; 以及配置为将入口孔，目标材料检测室和第一材料检测室彼此连接的通道。

公开(公告)号：US20160139037A1

公开(公告)日：2016-05-19

申请号：US14545606

申请日：2015-05-28

Applicant: Mark Salemo ,  I-Tsung Shih ,  Craig Harrison

Inventor： Mark Salemo ,  I-Tsung Shih ,  Craig Harrison

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N21/00 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/255 ,  G01N21/59 ,  G01N2021/0346 ,  G01N2201/0612 ,  G01N2201/0853 ,  G01N2201/121

Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

公开(公告)号：US20160130632A1

公开(公告)日：2016-05-12

申请号：US14897432

申请日：2014-06-11

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Ozan Akkus ,  Mikhail Slipchenko ,  Anna Akkus ,  Shan Yang ,  Bolan Li

IPC: C12Q1/40 ,  G01N1/40 ,  G01N21/65 ,  C12Q1/37

CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

Abstract translation: 用于确定特定化合物，特别是晶体是否存在于指示个体的生物流体样品中具有特定疾病或病症（例如但不限于痛风，假结肠或泌尿道结石）的方法。 在一些实施方案中，所述方法包括以下步骤：消化和过滤滑液样品，以便从样品中分离（如果存在的话）单酸一钠水溶液（MSU），焦磷酸钙二水合物（CPPD）或磷酸钙晶体，其中 用拉曼装置分析滤液以确定晶体的存在和类型。 公开了用于执行该方法的步骤的装置。

公开(公告)号：US20150355094A1

公开(公告)日：2015-12-10

申请号：US14829983

申请日：2015-08-19

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya FUKUYAMA

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N2201/10 ,  G01N2201/121 ,  G02B21/06 ,  G02B21/365

Abstract: A high-resolution fluorescence image in which an afterimage is suppressed is obtained, even when a fluorescence detection interval is shortened. Provided is a scanning observation apparatus including a scanning unit that spatially scans pulsed excitation light emitted from a light source at prescribed time intervals on a specimen; a fluorescence detecting unit that detects fluorescence generated by exciting a fluorescent substance inside the specimen with the excitation light scanned by the scanning unit, in synchronization with the emission of the excitation light; and a fluorescence correcting unit that subtracts, from a fluorescence intensity detected by the fluorescence detecting unit, an afterimage fluorescence component calculated on the basis of time-sequential fluorescence detected by the fluorescence detecting unit prior thereto, at each scanning position, to correct the fluorescence intensity at the scanning position.

Abstract translation: 即使在荧光检测间隔缩短的情况下也能够得到抑制残像的高分辨率的荧光图像。 本发明提供一种扫描观察装置，其具备：扫描单元，其以规定的时间间隔在样本上空间扫描从光源发出的脉冲激发光; 荧光检测单元，其与通过所述激发光的发射同步地检测利用所述扫描单元扫描的激发光来激发所述样本内的荧光物质而产生的荧光; 以及荧光校正单元，从荧光检测单元检测出的荧光强度，在每个扫描位置根据荧光检测单元检测到的时间序列荧光计算的余像荧光成分，从而校正荧光 在扫描位置的强度。

公开(公告)号：US20150346085A1

公开(公告)日：2015-12-03

申请号：US14648855

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain OBERTI ,  Johan FOURNEL

IPC: G01N21/27 ,  G01N21/3504

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: A method for controlling a spectrometer for analyzing a product includes steps of: acquiring a measurement representative of the operation of a light source, determining, depending on the measurement, a value of supply current of the light source, and/or a value of integration time of light-sensitive cells of a sensor, disposed on a route of a light beam emitted by the light source and having interacted with a product to be analyzed, and if the integration time and/or supply current value is between threshold values, supplying the light source with a supply current corresponding to the determined supply current value, adjusting the integration time of a light-sensitive cell to the determined integration time value, and acquiring light intensity measurements supplied by the sensor, enabling a spectrum to be formed.

Abstract translation: 一种用于控制用于分析产品的光谱仪的方法包括以下步骤：获取代表光源的操作的测量，根据测量确定光源的电源电流的值和/或积分值 传感器的感光单元的时间设置在由光源发射的光束的路径上并且与待分析的产品相互作用，并且如果积分时间和/或电源电流值在阈值之间，则提供 所述光源具有与所确定的电源电流值相对应的电源电流，将感光单元的积分时间调整到所确定的积分时间值，以及获取由所述传感器提供的光强度测量值，从而能够形成光谱。

公开(公告)号：US08736842B2

公开(公告)日：2014-05-27

申请号：US13266610

申请日：2010-04-14

Applicant: Helmut Scherer ,  Dieter Schrader ,  Stefan Menninger

Inventor： Helmut Scherer ,  Dieter Schrader ,  Stefan Menninger

IPC: G01N21/00 ,  G01J1/00 ,  G01N21/39 ,  G01N21/85 ,  G01J1/42

CPC classification number: G01N21/39 ,  G01J1/42 ,  G01J1/4257 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/61 ,  G01N21/8507 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/121 ,  G01N2201/1245 ,  G01N2201/12753

Abstract: The invention relates to an actuation and evaluation circuit for a laser diode (1) and a photodiode (3) for determining the concentration of a gas. The laser diode can generate light in the range of an absorption line of the gas. The circuit comprises a driver (10, 11, 12, 13) for generating a driving signal (17) for the laser diode (1), an assembly (8, 9) for generating a reference signal (20), and a subtractor (5) for subtracting the reference signal (20) from the signal (21) supplied by the photodiode. The invention further relates to a measuring device for determining the concentration of a gas by means of such an actuation and evaluation circuit. Finally, the invention relates to a corresponding method.

Abstract translation: 本发明涉及用于确定气体浓度的激光二极管（1）和光电二极管（3）的致动和评估电路。 激光二极管可以在气体的吸收线的范围内产生光。 电路包括用于产生用于激光二极管（1）的驱动信号（17）的驱动器（10,11,12,13），用于产生参考信号（20）的组件（8,9）和减法器 5），用于从由光电二极管提供的信号（21）中减去参考信号（20）。 本发明还涉及一种用于通过这种致动和评估电路确定气体浓度的测量装置。 最后，本发明涉及一种相应的方法。

公开(公告)号：US20130293894A1

公开(公告)日：2013-11-07

申请号：US13694899

申请日：2013-01-16

Applicant: Mark Salerno ,  I-Tsung Shih ,  Craig Harrison

Inventor： Mark Salerno ,  I-Tsung Shih ,  Craig Harrison

IPC: G01N21/59

CPC classification number: G01N21/31 ,  G01N21/00 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/255 ,  G01N21/59 ,  G01N2021/0346 ,  G01N2201/0612 ,  G01N2201/0853 ,  G01N2201/121

Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

公开(公告)号：US20120197575A1

公开(公告)日：2012-08-02

申请号：US13015624

申请日：2011-01-28

Applicant: Alexei SAVELIEV ,  Vilas Vyankatrao JANGALE ,  Sergeui ZELEPOUGA ,  John PRATAPAS

Inventor： Alexei SAVELIEV ,  Vilas Vyankatrao JANGALE ,  Sergeui ZELEPOUGA ,  John PRATAPAS

IPC: G01D18/00 ,  G06F19/00

CPC classification number: G01J3/42 ,  G01N21/276 ,  G01N21/3504 ,  G01N21/359 ,  G01N2201/121 ,  G01N2201/1273

Abstract: A method and apparatus for absorbance correction in a spectroscopic heating value sensor in which a reference light intensity measurement is made on a non-absorbing reference fluid, a light intensity measurement is made on a sample fluid, and a measured light absorbance of the sample fluid is determined. A corrective light intensity measurement at a non-absorbing wavelength of the sample fluid is made on the sample fluid from which an absorbance correction factor is determined. The absorbance correction factor is then applied to the measured light absorbance of the sample fluid to arrive at a true or accurate absorbance for the sample fluid.

Abstract translation: 在分光加热值传感器中进行吸光度校正的方法和装置，其中在非吸收参考流体上进行参考光强度测量，对样品流体进行光强度测量，并且测量样品流体的吸光度 决心，决意，决定。 在样品流体上对样品流体的非吸收波长进行校正光强度测量，其中确定吸光度校正因子。 然后将吸光度校正因子应用于测量的样品流体的吸光度，以获得样品流体的真实或准确的吸光度。