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公开(公告)号:US10593535B2
公开(公告)日:2020-03-17
申请号:US16320627
申请日:2016-09-21
Applicant: SHIMADZU CORPORATION
Inventor: Yusuke Tateishi
Abstract: A mass spectrometer including: an ionization chamber (11) that generates ions from a sample, a collision cell (222) located downstream from the ionization chamber (11), a mass separation unit (2412) located downstream from the collision cell (222), an energy barrier unit (223) located between the collision cell (222) and the mass separation unit (2412), a voltage application unit (30) that applies a voltage to each of the ionization chamber (11), the collision cell (222), and the energy barrier unit (223), and a control unit (42) that controls the voltage application unit (30) such that a potential of the ionization chamber (11) is set to a first potential, a potential of the collision cell (222) is set to a second potential that is lower than the first potential, and a potential of the energy barrier unit (223) is set to a third potential between the first potential and the second potential.
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公开(公告)号:US20200075301A1
公开(公告)日:2020-03-05
申请号:US16670703
申请日:2019-10-31
Applicant: Micromass UK Limited
Inventor: Zoltán TAKÁTS , Júlia BALOG , Steven Derek PRINGLE , Tamás KARANCSI , Michael Raymond MORRIS , Lajos GÖDÖRHÁZY , Dániel SZALAY , Dániel SIMON
IPC: H01J49/04 , H01J49/26 , H01J49/24 , H01J49/16 , H01J49/14 , H01J49/10 , H01J49/06 , H01J49/02 , H01J49/00 , G01N33/92 , G01N33/68 , G01N33/487 , G01N30/72 , G01N27/62 , G01N1/22 , C12Q1/24 , C12Q1/18 , C12Q1/04 , C12Q1/02 , A61F13/38 , A61B18/18 , A61B18/14 , A61B18/04 , A61B17/00 , A61B10/00 , A61B8/13 , A61B6/03 , A61B5/055 , A61B5/05 , A61B5/01 , A61B5/00 , A61B1/273 , A61B1/04 , A61B90/13 , G01N9/00 , G01N3/00 , A61B18/20 , A61B18/00 , A61B17/32 , A61B10/02
Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.
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公开(公告)号:US10580632B2
公开(公告)日:2020-03-03
申请号:US15846158
申请日:2017-12-18
Applicant: Agilent Technologies, Inc.
Inventor: Harry F. Prest , Charles W. Russ, IV
Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, one or more different conditioning gases are added to condition or modify one or more surfaces or regions of the ion source. The conditioning gas(es) may be added directly into the ion source. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample.
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公开(公告)号:US20200058478A1
公开(公告)日:2020-02-20
申请号:US16662881
申请日:2019-10-24
Applicant: Micromass UK Limited
Inventor: Tamas KARANCSI , Lajos GODORHAZY , Daniel SZALAY , Zoltan TAKATS , Julia BALOG , Steven Derek PRINGLE , Daniel SIMON
IPC: H01J49/04 , H01J49/26 , H01J49/24 , H01J49/16 , H01J49/14 , H01J49/10 , H01J49/06 , H01J49/02 , H01J49/00 , G01N33/92 , G01N33/68 , G01N33/487 , G01N30/72 , G01N27/62 , G01N1/22 , C12Q1/24 , C12Q1/18 , C12Q1/04 , C12Q1/02 , A61F13/38 , A61B18/18 , A61B18/14 , A61B18/04 , A61B17/00 , A61B10/00 , A61B8/13 , A61B6/03 , A61B5/055 , A61B5/05 , A61B5/01 , A61B5/00 , A61B1/273 , A61B1/04 , A61B90/13 , G01N9/00 , G01N3/00 , A61B18/20 , A61B18/00 , A61B17/32 , A61B10/02
Abstract: An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.
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公开(公告)号:US10564136B2
公开(公告)日:2020-02-18
申请号:US15780829
申请日:2015-12-04
Applicant: SHIMADZU CORPORATION
Inventor: Kazuma Maeda
Abstract: A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.
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公开(公告)号:US20200051802A1
公开(公告)日:2020-02-13
申请号:US16605392
申请日:2018-04-20
Applicant: Elemental Scientific Lasers, Inc.
Inventor: Leif C. Summerfield , Brock Meyer
Abstract: Systems and methods for an adjustable sample floor for ultrafast signal washout are disclosed. In an embodiment. A target support configured to adjustably support a target within a sample chamber may include: a support frame that may configured to be inserted into the sample chamber, a support platform that may be disposed within the support frame, and a platform adjustment system that may be coupled to the support frame and the support platform. The platform adjustment system may be configured to adjust at least one of: a position and an orientation of the support platform relative to the support frame when the support frame is inserted into the sample chamber.
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公开(公告)号:US10557835B2
公开(公告)日:2020-02-11
申请号:US14753272
申请日:2015-06-29
Applicant: Thermo Fisher Scientific Oy
Inventor: Robert DeWitte , Juhani Siidorov , Vesa Nuotio , Raimo Salminen , Jarmo Vehkomaki , Jukka Saukkonen , Bill Ostman , Joseph M. Senteno , John Edward Brann, III , Joseph L. Herman , Jeffrey A. Zonderman , Terry N. Olney
IPC: G01N30/72 , G01N35/00 , G01N35/08 , H01J49/26 , G01N30/06 , G01N30/86 , G01N35/02 , G01N27/62 , H01J49/04 , H01J49/00 , H01J49/10 , G01N30/88 , G01N30/16 , G06F19/00 , G01N30/02 , G01N30/62
Abstract: A sample preparation and analysis system. The system includes a sample preparation system and a sample analysis system. The sample preparation system prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system includes an analyzer that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link communicates data from the sample preparation system to the sample analysis system to reconfigure the analyzer in accordance with the selected assay.
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公开(公告)号:US20200043713A1
公开(公告)日:2020-02-06
申请号:US16601869
申请日:2019-10-15
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor: Alexander Alekseevich MAKAROV , Lothar ROTTMANN
Abstract: A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus.
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公开(公告)号:US20200041471A1
公开(公告)日:2020-02-06
申请号:US16339089
申请日:2016-11-29
Applicant: SHIMADZU CORPORATION
Inventor: Manabu UEDA
Abstract: An ionizer includes an ionization probe (21) provided with a capillary (211), a metallic slender tube (212), and a nebulizing gas pipe (213). The ionization probe (21) is equipped to perform ESI-based ionization of components in a liquid sample. An electroconductive capillary (22) is disposed at a position forward in a flow direction of a nebulized flow of the liquid sample from the ionization probe (21). A high voltage from a high voltage power supply (23) is applied to the electroconductive capillary (22) to induce corona discharge so that the components in the liquid sample are ionized by the APCI as well. At the time of tuning the ionizer, a standard sample solution is provided through the electroconductive capillary (22), and a high voltage from the high voltage power supply (23) is applied to the electroconductive capillary (22) so that components in the standard sample solution are ionized by the ESI or due to an ion molecular reaction with solvent molecular ions produced in the ionization probe (21). Thus, components in a standard sample can be ionized and subjected to mass spectrometry without pipe rearranging operations or without switch to and from different flow paths using a valve.
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公开(公告)号:US10529532B2
公开(公告)日:2020-01-07
申请号:US16381512
申请日:2019-04-11
Applicant: ULVAC, INC.
Inventor: Takumi Yuze , Toshihiro Terasawa , Naruyasu Sasaki
IPC: H01J37/08 , H01J27/08 , H01J49/10 , H01J37/30 , H01J37/317 , H01J27/02 , H01L21/265
Abstract: An ion source having an ion generation container configured to generate ions by reacting ionized gas introduced into the container via a tubular gas introduction pipe with an ion source material emitted in the container. The gas introduction pipe is configured to introduce the ionized gas into an inner space of the gas introduction pipe via a gas supply pipe. In the inner space of the gas introduction pipe, a detachable cooling trap member is disposed and includes a cooling trap portion configured to cool and trap a byproduct produced in the ion generation container. The cooling trap portion is disposed near a supply-side leading end of the gas supply pipe in the inner space of the gas introduction pipe and is not contact with an interior wall face of the gas introduction pipe.
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