公开(公告)号：US20170081639A1

公开(公告)日：2017-03-23

申请号：US15312273

申请日：2015-05-19

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Shoen KUME ,  Nobuaki SHIRAKI

IPC: C12N5/071 ,  G01N33/50

CPC classification number: C12N5/0676 ,  A61K35/12 ,  C12N5/0678 ,  C12N15/09 ,  C12N2500/92 ,  C12N2500/98 ,  C12N2501/01 ,  C12N2501/119 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/73 ,  C12N2506/45 ,  C12N2533/52 ,  G01N33/507 ,  G01N33/5073 ,  G01N33/74

Abstract: It is an object of the present invention to provide a method for efficiently directing differentiation into insulin-producing cells in a xeno-free culture system. According to the present invention, there is provided a method for directed differentiation into insulin-producing cells, comprising culturing stem cells in the following steps (1) to (5): (1) a step of culturing stem cells in a medium comprising an activator of activin receptor-like kinase-4/-7 and a GSK3 inhibitor and then culturing in a medium comprising an activator of activin receptor-like kinase-4/-7; (2) a step of culturing the cells obtained in step (1) in a medium comprising a hedgehog signaling inhibitor and an FGF; (3) a step of culturing the cells obtained in step (2) in a medium comprising a retinoic acid receptor agonist, a hedgehog signaling inhibitor and a BMP signaling inhibitor; (4) a step of culturing the cells obtained in step (3) in a medium comprising a TGF-β type I activin receptor-like kinase-4/-5/-7 inhibitor and a BMP signaling inhibitor; and (5) a step of culturing the cells obtained in step (4) in a medium comprising a phosphodiesterase inhibitor.

公开(公告)号：US09595715B2

公开(公告)日：2017-03-14

申请号：US14369507

申请日：2012-12-27

Applicant: National University Corporation Okayama University ,  Tokyo Institute of Technology ,  Kyoto University

Inventor： Jun Takada ,  Hideki Hashimoto ,  Tatsuo Fujii ,  Makoto Nakanishi ,  Ryoji Kanno ,  Genki Kobayashi ,  Mikio Takano

IPC: H01M4/88 ,  H01M4/525 ,  H01M4/52 ,  H01M4/131 ,  H01M4/58 ,  H01M4/62 ,  H01M10/0525

CPC classification number: H01M4/525 ,  H01M4/131 ,  H01M4/523 ,  H01M4/5825 ,  H01M4/621 ,  H01M4/623 ,  H01M4/624 ,  H01M4/625 ,  H01M10/0525 ,  H01M2220/30 ,  Y02E60/122

Abstract: This invention relates to an anode active material comprising at least one iron oxide selected from the group consisting of amorphous iron oxides, ferrihydrite, and lepidocrocite. The invention also relates to a lithium ion secondary battery anode material comprising the anode active material as a constituent component, a lithium ion secondary battery anode comprising the lithium ion secondary battery anode material, and a lithium ion secondary battery comprising the lithium ion secondary battery anode.

Abstract translation: 本发明涉及一种负极活性材料，其包含至少一种选自无定形氧化铁，铁水合物和锂铁矿石的氧化铁。 本发明还涉及包含负极活性物质作为构成成分的锂离子二次电池负极材料，包含锂离子二次电池负极材料的锂离子二次电池负极材料和锂离子二次电池负极 。

公开(公告)号：US20170066748A1

公开(公告)日：2017-03-09

申请号：US15254090

申请日：2016-09-01

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Masahito TOYAMA ,  Masato KIRIU ,  Hiroshi TANAKA

IPC: C07D405/06 ,  A61K51/04

CPC classification number: C07D405/06 ,  A61K51/0453 ,  C07B59/00 ,  C07B2200/05 ,  Y02P20/55

Abstract: There is provided a labeling precursor compound represented by the following general formula (2): wherein R1 represents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a monocyclic or condensed polycyclic aryl group or a nitrogen-containing heterocycle; R2 and R3 each independently represent an alkyl group or a hydroxyalkyl group which hydroxy group may be protected with a protecting group, and n is an integer of 1 or 2; R6 represents an alkyl group or —CONR11R12 wherein R11 and R12 each independently represent an alkyl group or a monocyclic or condensed polycyclic aryl group; and R4, R5, R7 and R8 each independently represent a hydrogen atom, an alkyl group or an alkoxy group.

Abstract translation: 其中R1表示炔基，炔氧基，叠氮基，叠氮基烷基，芳基叠氮基，单环或缩合多环芳基或含氮杂环; R2和R3各自独立地表示羟基可被保护基保护的烷基或羟烷基，n为1或2的整数; R6表示烷基或-CONR11R12，其中R11和R12各自独立地表示烷基或单环或缩合多环芳基; 并且R 4，R 5，R 7和R 8各自独立地表示氢原子，烷基或烷氧基。

公开(公告)号：US20170056885A1

公开(公告)日：2017-03-02

申请号：US15258454

申请日：2016-09-07

Applicant: TOPPAN PRINTING CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Masahiro TAKINOUE ,  Masamune MORITA ,  Hitoyoshi YAMASHITA

IPC: B01L3/00 ,  B01J19/00 ,  B01J13/04

CPC classification number: B01L3/502784 ,  B01J13/04 ,  B01J19/0093 ,  B01J2219/00797 ,  B01J2219/00891 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2300/0832 ,  B01L2400/0409

Abstract: A droplet producing device includes an outer tube; and an inner tube that is arranged inside the outer tube and feeds a droplet raw material, in which an inner tube discharge port opens to an inner tube tip portion formed on a downstream in a fluid feed direction, an outer tube discharge port opens to an outer tube tip portion formed on the downstream in the fluid feed direction, and in which a gap is formed between the outer tube and the inner tube.

Abstract translation: 液滴产生装置包括外管; 以及内管，其设置在所述外管的内部，并且供给液滴原料，所述液滴原料通过内管排出口向形成在流体供给方向的下游的内管末端部开口，外管排出口向 形成在流体供给方向下游的外管末端部分，并且在外管和内管之间形成有间隙。

公开(公告)号：US09583637B2

公开(公告)日：2017-02-28

申请号：US14806108

申请日：2015-07-22

Applicant: CANON KABUSHIKI KAISHA ,  TOKYO INSTITUTE OF TECHNOLOGY ,  Japan Science and Technology Agency

Inventor： Masafumi Sano ,  Katsumi Nakagawa ,  Hideo Hosono ,  Toshio Kamiya ,  Kenji Nomura

IPC: H01L29/06 ,  H01L29/786 ,  H01L21/428 ,  H01L21/02 ,  H01L29/66

CPC classification number: H01L29/78693 ,  H01L21/02422 ,  H01L21/02554 ,  H01L21/02565 ,  H01L21/02592 ,  H01L21/02631 ,  H01L21/428 ,  H01L27/1225 ,  H01L27/124 ,  H01L29/66969 ,  H01L29/7869 ,  H01L29/78696

Abstract: A novel amorphous oxide applicable, for example, to an active layer of a TFT is provided. The amorphous oxide comprises microcrystals.

Abstract translation: 提供了可应用于例如TFT的有源层的新颖的无定形氧化物。 无定形氧化物包括微晶。

公开(公告)号：US09573822B2

公开(公告)日：2017-02-21

申请号：US14423303

申请日：2013-08-20

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideo Hosono ,  Michikazu Hara ,  Yasunori Inoue ,  Masaaki Kitano ,  Fumitaka Hayashi ,  Toshiharu Yokoyama ,  Satoru Matsuishi ,  Yoshitake Toda

IPC: C01F7/00 ,  C01F7/16 ,  C01C1/04 ,  B01J37/08 ,  B01J37/16 ,  B01J21/16 ,  B01J23/58 ,  B01J23/02 ,  B01J35/00 ,  B01J37/02 ,  B01J37/04 ,  C01F7/02 ,  B01J37/10 ,  B01J37/18 ,  B01J37/34 ,  B01J35/10

CPC classification number: B01J21/16 ,  B01J23/02 ,  B01J23/462 ,  B01J23/58 ,  B01J35/0006 ,  B01J35/0033 ,  B01J35/026 ,  B01J35/1009 ,  B01J35/1014 ,  B01J37/0201 ,  B01J37/04 ,  B01J37/08 ,  B01J37/082 ,  B01J37/10 ,  B01J37/16 ,  B01J37/18 ,  B01J37/347 ,  C01B33/26 ,  C01C1/0411 ,  C01F7/02 ,  C01F7/164 ,  C01P2006/12 ,  C01P2006/40 ,  Y02P20/52 ,  Y10T428/2982

Abstract: If a conductive mayenite compound having a large specific surface area is obtained, the usefulness thereof in respective applications is remarkably increased. A conductive mayenite compound powder having a conduction electron density of 1015 cm−3 or more and a specific surface area of 5 m2g−1 or more is produced by: (1) a step for forming a precursor powder by subjecting a mixture of a starting material powder and water to a hydrothermal treatment; (2) a step for forming a mayenite compound powder by heating and dehydrating the precursor powder; (3) a step for forming an activated mayenite compound powder by heating the compound powder in an inert gas atmosphere or in a vacuum; and (4) a step for injecting electrons into the mayenite compound through a reduction treatment by mixing the activated mayenite compound powder with a reducing agent.

Abstract translation: 如果获得具有大比表面积的导电钙铝石化合物，其在各种应用中的用途显着增加。 导电电子密度为1015cm-3以上，比表面积为5m 2·g -1以上的导电钙铝石类化合物粉末是通过以下方法制造的：（1）通过使起始物 材料粉末和水进行水热处理; （2）通过加热和脱水前体粉末形成钙铝石化合物粉末的步骤; （3）通过在惰性气体气氛或真空中加热化合物粉末来形成活化的钙铝石化合物粉末的步骤; 和（4）通过将活化的钙铝石化合物粉末与还原剂混合来通过还原处理将电子注入钙铝石化合物的步骤。

公开(公告)号：US20160361712A1

公开(公告)日：2016-12-15

申请号：US15121702

申请日：2015-02-12

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideo HOSONO ,  Michikazu HARA ,  Masaaki KITANO ,  Toshiharu YOKOYAMA ,  Yasunori INOUE ,  Shinji KAMBARA

IPC: B01J27/24 ,  B01J23/75 ,  C01C1/04 ,  B01J27/22 ,  B01J35/00 ,  B01J23/46 ,  B01J23/745

CPC classification number: B01J27/24 ,  B01J23/462 ,  B01J23/745 ,  B01J23/75 ,  B01J27/22 ,  B01J35/0006 ,  B01J35/1009 ,  C01B21/0612 ,  C01C1/0411 ,  C01P2006/12 ,  Y02P20/52

Abstract: A catalyst is provided which is used for continuously synthesizing ammonia using a gas containing hydrogen and nitrogen as a raw material, wherein a transition metal which exhibits catalytic activity is supported by a support, and the support is a two-dimensional electride or a precursor thereof. The two-dimensional electride or the precursor thereof is a metal nitride represented by MxNyHz (M represents one or two or more of Group II metals selected from the group consisting of Mg, Ca, Sr and Ba, and x, y and z are in ranges of 1≦x≦11, 1≦y≦8, and 0≦z≦4 respectively, in which x is an integer, and y and z are not limited to an integer) or M3N2 (M is the same as above), or a metal carbide selected from the group consisting of Y2C, Sc2C, Gd2C, Tb2C, Dy2C, Ho2C and Er2C. These catalysts are used for continuously reacting nitrogen with hydrogen, which are raw materials, on the catalyst, wherein the reaction is performed in an ammonia synthesis reaction system under the preferable conditions of a reaction temperature which is equal to or higher than 100° C. and equal to or lower than 600° C., and a reaction pressure which is equal to or higher than 10 kPa and lower than 20 MPa.

Abstract translation: 提供了一种催化剂，其用于使用含有氢气和氮气的气体作为原料连续合成氨，其中具有催化活性的过渡金属由载体负载，并且载体是二维电子或其前体 。 二维电子电极或其前体是以M x N y H z表示的金属氮化物（M表示选自Mg，Ca，Sr和Ba的第II族金属中的一种或两种以上，x，y和z在 分别为1≤x≤11,1≤y≤8,0≤z≤4的范围，其中x为整数，y和z不限于整数）或M3N2（M与上述相同） 或选自Y2C，Sc2C，Gd2C，Tb2C，Dy2C，Ho2C和Er2C的金属碳化物。 这些催化剂用于使氮气与作为原料的氢气在催化剂上连续反应，其中反应在反应温度等于或高于100℃的优选条件下在氨合成反应体系中进行。 等于或低于600℃，反应压力等于或高于10kPa并低于20MPa。

公开(公告)号：US20160340182A1

公开(公告)日：2016-11-24

申请号：US15211599

申请日：2016-07-15

Applicant: TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideo Hosono ,  Fumitaka Hayashi ,  Toshiharu Yokoyama ,  Yoshitake Toda ,  Michikazu Hara ,  Masaaki Kitano

IPC: C01B3/04 ,  B01J23/78 ,  B01J23/58

CPC classification number: C01B3/047 ,  B01J21/16 ,  B01J23/58 ,  B01J23/78 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/0033 ,  B01J35/006 ,  B01J35/0066 ,  B01J35/1009 ,  B01J35/1014 ,  B01J37/0203 ,  B01J37/0207 ,  B01J37/0238 ,  B01J37/08 ,  B01J37/10 ,  B01J37/16 ,  B01J37/18 ,  B01J37/348 ,  C01B3/04 ,  H01M8/0606 ,  Y02E60/324 ,  Y02E60/364

Abstract: A metal-supporting catalyst for decomposing ammonia into hydrogen and nitrogen. The catalyst shows a high performance with a low cost and being advantageous from the viewpoint of resources, and an efficient method for producing hydrogen using the catalyst. The catalyst catalytically decomposes ammonia gas to generate hydrogen. The hydrogen generation catalyst includes, as a support, a mayenite type compound having oxygen ions enclosed therein or a mayenite type compound having 1015 cm−3 or more of conduction electrons or hydrogen anions enclosed therein, and metal grains for decomposing ammonia are supported on the surface of the support. Hydrogen is produced by continuously supplying 0.1-100 vol % of ammonia gas to a catalyst layer that comprises the aforesaid catalyst, and reacting the same at a reaction pressure of 0.01-1.0 MPa, at a reaction temperature of 300-800° C. and at a weight hourly space velocity (WHSV) of 500/mlg−1h−1 or higher.

公开(公告)号：US09496805B2

公开(公告)日：2016-11-15

申请号：US14360251

申请日：2012-11-15

Applicant: Tokyo Institute of Technology

Inventor： Hirofumi Akagi ,  Makoto Hagiwara

IPC: H02M7/483 ,  H02M7/797 ,  H02M7/497 ,  H02M7/537 ,  H02M7/538

CPC classification number: H02M7/797 ,  H02M7/483 ,  H02M7/497 ,  H02M7/537 ,  H02M7/53803 ,  H02M2007/4835

Abstract: This power converter (1) is provided with: unit cells (11-M) having a semiconductor switch, a DC capacitor (C) and a charge/discharge current I/O terminal; a first arm (12-P) and a second arm (12-N) comprising multiple unit cells (11-M) connected to each other in cascade; an arm connecting unit (13) which has a first terminal to which the first arm (12-P) is connected, a second terminal to which the second arm (12-N) is connected, and a third terminal to which a DC power source is connected; and a transformer (14) which has an AC I/O terminal on the primary side and an intermediate terminal on the secondary side winding, and in which the terminal of the first arm (12-P) and the terminal of the second arm (12-N) are connected to the two end terminals on the secondary winding, and the DC power source (Vdc) is connected to the intermediate terminal.

Abstract translation: 该功率转换器（1）具有：具有半导体开关的单元电池（11-M），直流电容器（C）和充放电电流I / O端子; 包括彼此串联连接的多个单电池（11-M）的第一臂（12-P）和第二臂（12-N） 臂连接单元（13），其具有连接有第一臂（12-P）的第一端子，与第二臂（12-N）连接的第二端子，以及第三端子，DC电源 来源连接; 以及变压器（14），其在初级侧具有AC I / O端子和在次级侧绕组上的中间端子，并且其中第一臂（12-P）的端子和第二臂的端子（ 12-N）连接到次级绕组上的两个端子，并且直流电源（Vdc）连接到中间端子。

公开(公告)号：US20160257789A1

公开(公告)日：2016-09-08

申请号：US15055018

申请日：2016-02-26

Applicant: TOKYO OHKA KOGYO CO., LTD. ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Takehiro SESHIMO ,  Teruaki HAYAKAWA

IPC: C08G77/42 ,  B05D3/02 ,  B05D7/00

CPC classification number: C08G77/42 ,  C08G77/442 ,  C08G77/46

Abstract: A block copolymer containing a first block having a structure represented by general formula (1) shown below (Rs01 and Rs02 each independently represents an organic group, provided that at least one of Rs01 and Rs02 has a polar group; and * represents a valence bond).

Abstract translation: 含有具有如下所示的通式（1）所示结构的第一嵌段的嵌段共聚物（Rs01和Rs02各自独立地表示有机基团，条件是Rs01和Rs02中的至少一个具有极性基团; *表示价键 ）。