公开(公告)号：US20120014835A1

公开(公告)日：2012-01-19

申请号：US13143720

申请日：2010-01-08

Applicant: James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

Inventor： James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

IPC: G01N21/76

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.

Abstract translation: 公开了一种用于检测在多个反应容器（3）中发生的化学或生物化学反应产生的光中的光谱的装置。 每个反应容器（3）具有容纳部分，该容器部分具有能够发出光的发射区域。 该装置可以包括具有孔（6）阵列的掩模元件（5），来自每个反应容器（3）的光可以通过该孔排出。 多个光波导（7）布置成将来自掩模元件（5）中的孔（6）的光引导到用于将来自每个波导（7）的光分散到分散光谱中的光分散装置（8）。 光检测装置（10）基本上同时检测光的分散光谱中的特定光谱。 在一个实施例中，孔（6）的尺寸基本上小于反应容器的发射面积，但是在另一个实施例中，孔（6）的大小与反应容器的发射面积基本相似，并且光波导 （7）的直径从直径基本上类似于反应容器顶部的面积的第一端逐渐变细到直径基本上较小的第二端。 在替代实施例中，当来自小孔的光直接指向光分散装置时，不使用光波导。 在另一替代实施例中，为每个反应容器提供几个光波导，每个波导将光引导到不同的检测器以检测不同的特定光谱。

公开(公告)号：US20110312102A1

公开(公告)日：2011-12-22

申请号：US13162081

申请日：2011-06-16

Applicant: Sung-ho JO

Inventor： Sung-ho JO

IPC: G01N21/00

CPC classification number: G01N21/0332 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/1827 ,  B01L2300/185 ,  G01J3/0216 ,  G01J3/10 ,  G01J2003/1213 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0826

Abstract: A light transmissive temperature control apparatus, a bio-diagnosis apparatus including the transmissive temperature control apparatus, and a method of diagnosing biochemical reaction using the bio-diagnosing apparatus are provided. The light transmissive temperature control apparatus includes at least one tube which is formed of a light transmissive material and configured to contain a sample; and a temperature control unit which accommodates at least a part of the at least one tube which is transparent, guides light to be irradiated onto the at least one tube, and controls a temperature of the at least one tube.

Abstract translation: 提供了一种透光温度控制装置，包括透射温度控制装置的生物诊断装置和使用生物诊断装置诊断生化反应的方法。 透光温度控制装置包括由透光材料形成并构造成容纳样品的至少一个管; 以及温度控制单元，其容纳至少一个透明的管的至少一部分，将要照射的光引导到至少一个管上，并控制至少一个管的温度。

公开(公告)号：US20110066014A1

公开(公告)日：2011-03-17

申请号：US12875925

申请日：2010-09-03

Applicant: Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

Inventor： Kate Leeann Bechtel ,  Tobias Funk ,  Brian Patrick Wilfley ,  Joseph Anthony Heanue

IPC: A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/0091 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The present invention pertains to a method and apparatus for cerebral oximetry. A modulated optical signal based on a digital code sequence is transmitted to the human brain. A temporal transfer characteristic is derived from the modulated optical signal. Oxygen level in the brain is determined based on the temporal transfer characteristic.

Abstract translation: 本发明涉及脑血氧测定法的方法和装置。 基于数字码序列的调制光信号被传送到人脑。 从调制光信号导出时间传递特性。 基于时间转移特征确定脑中的氧水平。

公开(公告)号：US07843559B2

公开(公告)日：2010-11-30

申请号：US11476358

申请日：2006-06-28

Applicant: Dov Furman ,  Gad Neumann ,  Mark Wagner ,  Noam Dotan ,  Ram Segal ,  Shai Silberstein

Inventor： Dov Furman ,  Gad Neumann ,  Mark Wagner ,  Noam Dotan ,  Ram Segal ,  Shai Silberstein

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N21/8806 ,  G01N21/95607 ,  G01N21/95623 ,  G01N2021/479 ,  G01N2021/8825 ,  G01N2201/0697 ,  G01N2201/0826

Abstract: Fast on-line electro-optical detection of wafer defects by illuminating with a short light pulse from a repetitively pulsed laser, a section of the wafer while it is moved across the field of view of an imaging system, and imaging the moving wafer onto a focal plane assembly, optically forming a continuous surface of photo-detectors at the focal plane of the optical imaging system. The continuously moving wafer is illuminated by a laser pulse of duration significantly shorter than the pixel dwell time, such that there is effectively no image smear during the wafer motion. The laser pulse has sufficient energy and brightness to impart the necessary illumination to each sequentially inspected field of view required for creating an image of the inspected wafer die. A novel fiber optical illumination delivery system, which is effective in reducing the effects of source coherence is described. Other novel aspects of the system include a system for compensating for variations in the pulse energy of a Q-switched laser output, methods for autofocussing of the wafer imaging system, and novel methods for removal of repetitive features of the image by means of Fourier plane filtering, to enable easier detection of wafer defects.

Abstract translation: 通过用来自重复脉冲激光器的短光脉冲照射晶片缺陷的快速在线电光检测，晶片的一部分在成像系统的视场内移动，并将移动的晶片成像到 焦平面组件，在光学成像系统的焦平面处光学地形成光电检测器的连续表面。 持续移动的晶片被持续时间明显短于像素停留时间的激光脉冲照亮，使得在晶片运动期间实际上没有图像污迹。 激光脉冲具有足够的能量和亮度，以对于产生被检查的晶片管芯的图像所需的每个顺序检查的视场赋予必要的照明。 描述了一种有效减少源相干效应的新型光纤照明传输系统。 该系统的其他新颖的方面包括用于补偿Q开关激光输出的脉冲能量变化的系统，用于晶片成像系统的自动聚焦的方法，以及通过傅里叶平面去除图像的重复特征的新颖方法 过滤，以便更容易地检测晶片缺陷。

公开(公告)号：US20100157300A1

公开(公告)日：2010-06-24

申请号：US12503755

申请日：2009-07-15

Applicant: Dae-Sik Lee ,  Yo-Han Choi ,  Hyun-Woo Song ,  Moon-Youn Jung ,  Seon-Hee Park ,  Gun-Yong Sung

Inventor： Dae-Sik Lee ,  Yo-Han Choi ,  Hyun-Woo Song ,  Moon-Youn Jung ,  Seon-Hee Park ,  Gun-Yong Sung

IPC: G01J3/46

CPC classification number: G01N21/253 ,  G01N21/8483 ,  G01N2201/0256 ,  G01N2201/0826

Abstract: Provided is a liquid sample analysis chip reading system. The reading system includes an analysis chip, a light emitting part, a plurality of light wave-guides, and a light receiving part. The analysis chip includes a plurality of detecting parts. The light emitting part includes three light sources emitting light having wavelengths (or colors) different from each other. The plurality of light wave-guides irradiate the light emitted from the light emitting part onto the plurality of corresponding detecting parts, respectively. The light receiving part includes a plurality of light receiving devices for receiving the light having a specific color reflected from each of the plurality of corresponding detecting parts of the analysis chip. The three light sources are discontinuously controlled to emit light onto the plurality of light wave-guides.

Abstract translation: 提供了一种液体样品分析芯片读取系统。 读取系统包括分析芯片，发光部分，多个光波导和光接收部分。 分析芯片包括多个检测部分。 发光部分包括发射具有彼此不同的波长（或颜色）的光的三个光源。 多个光波导将从发光部发射的光分别照射到多个相应的检测部上。 光接收部分包括多个光接收装置，用于接收从分析芯片的多个相应的检测部分中的每一个反射的具有特定颜色的光。 不连续地控制三个光源以将光发射到多个光波导上。

公开(公告)号：US20100123088A1

公开(公告)日：2010-05-20

申请号：US12692758

申请日：2010-01-25

Applicant: Petri KIVELÄ

Inventor： Petri KIVELÄ

IPC: G01J1/58

CPC classification number: G01N21/253 ,  G01N21/13 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0826 ,  G01N2201/103

Abstract: The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample (281-285) is activated (212AS, 218AS) and the emission is detected (291, 292), wherein between the activation and detection phases of measuring the sample, a shift is made in the relative position between the sample and means (218) directing the activation radiation to the sample as well as in the relative position between the sample and the means (293) receiving the emission radiation from the sample. This can be implemented e.g. by moving (299) the sample assay plate and/or a measuring head between the activation and emission phases of a sample. The invention allows a simultaneous activation of a first sample and detecting emission from a second sample thus enhancing efficiency of the measurement.

Abstract translation: 本发明一般涉及生物化学实验室仪器领域，用于不同应用样品的测量性质。 微量滴定板和相应的样品支架。 本发明的目的是通过提供一种光学测量仪器实现的，其中样品（281-285）被激活（212AS，218AS）并且检测到发射（291,292），其中在测量样品的激活和检测阶段之间 在样品和将激活辐射指向样品的装置（218）之间的相对位置以及样品和接收来自样品的发射辐射的装置（293）之间的相对位置进行位移。 这可以被实现。 通过在样品的活化和发射阶段之间移动（299）样品测定板和/或测量头。 本发明允许同时激活第一样品并检测来自第二样品的发射，从而提高测量的效率。

公开(公告)号：US20100032582A1

公开(公告)日：2010-02-11

申请号：US12187815

申请日：2008-08-07

Applicant: Hua Xia ,  Li Zhu ,  Eugene Barash ,  Erin Jean Finehout ,  Matthew Damian Pietrzykowski

Inventor： Hua Xia ,  Li Zhu ,  Eugene Barash ,  Erin Jean Finehout ,  Matthew Damian Pietrzykowski

IPC: G01N21/64

CPC classification number: G01N21/645 ,  B01L3/5027 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/08 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fluorescence detection system comprises a light source configured to produce an excitation light, an optical lens and a fiber bundle. The optical lens is configured to focus the excitation light to a sample to emit fluorescence and to collect the fluorescence. The fiber bundle probe comprises a transmitting fiber configured to transmit the excitation light to the optical lens, and a first receiving fiber configured to deliver the collected fluorescence. The fluorescence detection system further comprises a first detector configured to detect the fluorescence delivered by the receiving fiber to generate a response signal, and a processing unit configured to determine information about the samples by analyzing the response signal. Additionally, a fluorescence detection method is also presented.

Abstract translation: 荧光检测系统包括被配置为产生激发光，光学透镜和光纤束的光源。 光学透镜被配置为将激发光聚焦到样品以发射荧光并收集荧光。 纤维束探针包括被配置为将激发光透射到光学透镜的发射光纤和被配置为传送所收集的荧光的第一接收光纤。 荧光检测系统还包括第一检测器，其被配置为检测由接收光纤传送的荧光以产生响应信号;以及处理单元，被配置为通过分析响应信号来确定关于样本的信息。 另外，还提出了荧光检测方法。

公开(公告)号：US20100020319A1

公开(公告)日：2010-01-28

申请号：US12507585

申请日：2009-07-22

Applicant: Stavros G. Demos ,  Miroslav Y. Shverdin ,  Michael D. Shirk

Inventor： Stavros G. Demos ,  Miroslav Y. Shverdin ,  Michael D. Shirk

IPC: G01J3/44 ,  G01J3/30

CPC classification number: G01N21/6456 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2021/651 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/06166 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Portable, field-deployable laser synthesizer devices designed for multi-dimensional spectrometry and time-resolved and/or hyperspectral imaging include a coherent light source which simultaneously produces a very broad, energetic, discrete spectrum spanning through or within the ultraviolet, visible, and near infrared wavelengths. The light output is spectrally resolved and each wavelength is delayed with respect to each other. A probe enables light delivery to a target. For multidimensional spectroscopy applications, the probe can collect the resulting emission and deliver this radiation to a time gated spectrometer for temporal and spectral analysis.

Abstract translation: 设计用于多维光谱法和时间分辨和/或高光谱成像的便携式现场可部署激光合成器装置包括相干光源，其同时产生跨越紫外线，可见光和近紫外线的非常宽泛，高能的离散光谱 红外波长。 光输出被光谱分解，并且每个波长相对于彼此延迟。 探头可以轻松传送到目标。 对于多维光谱应用，探针可以收集所得到的发射并将该辐射传递到时间选通光谱仪用于时间和光谱分析。

公开(公告)号：US07466418B2

公开(公告)日：2008-12-16

申请号：US11670376

申请日：2007-02-01

Applicant: David Nilson ,  Brad Rice ,  Tamara Troy

Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

IPC: G01J3/30 ,  G01N21/25

CPC classification number: G01N21/6456 ,  A01K1/031 ,  A61M16/104 ,  A61M16/18 ,  A61M16/202 ,  A61M2016/0039 ,  G01N2021/1787 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface facing toward the view port of the imaging apparatus. The support surface defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between.

Abstract translation: 提供了一种宏观荧光照明组件，用于与具有不透光成像室的成像装置一起使用。 该成像设备包括限定了一个视图端口的内壁，该视图端口延伸到成像室中以使得能够观察其中容纳的样本。 照明组件包括面向成像设备的视口的样本支撑表面。 支撑表面限定了能够使光通过的窗口部分。 窗口部分被选择性地定尺寸和尺寸使得当被支撑在支撑表面上方时，样本可以以基本上在其之间形成不透光密封的方式被定位和安置在窗口部分上。

公开(公告)号：US07461961B2

公开(公告)日：2008-12-09

申请号：US11740569

申请日：2007-04-26

Applicant: Falai Li

Inventor： Falai Li

IPC: F21V7/04

CPC classification number: H01L21/67288 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/8822 ,  G01N2201/08 ,  G01N2201/0826

Abstract: A fiber optic darkfield ring light with many angled fiber optic light lines with direct illumination in a very small package. The fiber optic darkfield ring light includes a base with multiple light heads and multiple light covers attached thereto, a main cover, an optional cord grip, and an optional hood. It incorporates multiple fiber optic line arrays positioned at low angle and used in conjunction with a strobe light source.

Abstract translation: 一种光纤暗场环形灯，具有许多成角度的光纤光线，具有非常小的封装中的直接照明。 光纤暗场环形灯包括具有多个光头的基座和附接到其上的多个灯罩，主盖，可选的绳把和可选的罩。 它集成了多个光栅线阵列，它们以低角度定位并与闪光灯光源一起使用。