公开(公告)号：US06831271B1

公开(公告)日：2004-12-14

申请号：US09762238

申请日：2001-05-09

Applicant: Roger Guevremont ,  Randy Purves ,  David Barnett

Inventor： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC: H01J4940

CPC classification number: G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

Abstract: The present invention relates to a method for separating and enriching stable isotopes in gas phase using the principles of high field asymmetric waveform ion mobility spectrometry, substantially at atmospheric pressure (760 torr) and substantially at room temperature (298 K). Specifically, the method of the present invention may be used to separate and enrich isotopes of chlorine. Electrospray ionization may be used to generate a gaseous mixture of ions and the ion beam exiting the high field asymmetric waveform ion mobility spectrometer may be sampled into a mass spectrometer for isotope identification.

Abstract translation: 本发明涉及一种基于大气压（760乇）和基本上在室温（298K）的高场非对称波形离子淌度光谱法的原理分离和富集气相中稳定同位素的方法。 具体地说，本发明的方法可用于分离和富集氯的同位素。 可以使用电喷雾离子化来产生离子的气体混合物，离开高场非对称波形离子迁移谱仪的离子束可以被采样到用于同位素鉴定的质谱仪中。

公开(公告)号：US06646254B2

公开(公告)日：2003-11-11

申请号：US09845287

申请日：2001-05-01

Applicant: Yasufumi Tanaka

Inventor： Yasufumi Tanaka

IPC: H01J4942

CPC classification number: H01J49/067 ,  G01N30/724 ,  H01J49/044 ,  H01J49/063

Abstract: A liquid chromatograph mass spectrometer includes a solvent removing tube, a first ion lens and a second ion lens. Voltages applied to the solvent removing tube, and the first and second ion lenses corresponding to each mass number of a standard sample are studied in advance so that efficiencies of passing ions become best. A voltage scanning pattern is made based on the impressed voltages, and stored in a memory portion. When a scanning measurement is carried out, a control portion controls a current voltage source and a high frequency voltage source according to the voltage scanning pattern, synchronizing with the scanning of the impressed voltage to the quadrupole filter. As a result of the control, an objective ion which is generated by being atomized from a nozzle may effectively pass through the entrance of a quadrupole filter.

Abstract translation: 液相色谱质谱仪包括溶剂去除管，第一离子透镜和第二离子透镜。 预先施加到溶剂去除管的电压以及与标准样品的每个质量数对应的第一和第二离子透镜，使得通过离子的效率变得最佳。 基于外加电压进行电压扫描图案，并存储在存储器部分中。 当执行扫描测量时，控制部分根据电压扫描图案控制电流电压源和高频电压源，与向四极滤波器的外加电压的扫描同步。 作为控制的结果，通过从喷嘴雾化产生的客观离子可以有效地通过四极过滤器的入口。

公开(公告)号：US06593568B1

公开(公告)日：2003-07-15

申请号：US09324401

申请日：1999-06-02

Applicant: Craig M. Whitehouse ,  Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Clement Catalano

Inventor： Craig M. Whitehouse ,  Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Clement Catalano

IPC: B01D5944

CPC classification number: H01J49/0477 ,  H01J49/0404 ,  H01J49/044

Abstract: An Atmospheric Pressure Ion (API) source is configured for Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) operating modes. The API source includes a multipurpose heater assembly mounted in the API source chamber. The multipurpose heater supplies heat to the API chamber endplate, bath gas and entrance end of the capillary orifice into vacuum as well as supplying electrical connections to the API source elements. An additional heater is configured at the exit end of the capillary orifice into vacuum. With this configuration, the bath gas, endplate and capillary entrance temperature can be set independent of gas flow rate. The capillary exit and entrance temperatures can be set independently as well. The multipurpose endplate heater combined with the capillary exit heater allows the optimization of API source performance over a wide range of operating conditions and analytical applications.

Abstract translation: 大气压离子（API）源被配置用于电喷雾（ES）和大气压化学电离（APCI）操作模式。 API源包括安装在API源室中的多用途加热器组件。 多功能加热器将API室端板，浴室气体和毛细孔入口端的热量提供到真空中，并向API源元件提供电气连接。 另外的加热器配置在毛细管孔的出口端进入真空。 通过这种配置，浴气，终板和毛细管入口温度可独立于气体流量设定。 毛细管出口和入口温度也可以独立设置。 多用途终板加热器与毛细管出口加热器相结合，可以在广泛的操作条件和分析应用中优化API源性能。

公开(公告)号：US06586732B2

公开(公告)日：2003-07-01

申请号：US09788837

申请日：2001-02-20

Applicant: Milton L. Lee ,  David C. Collins

Inventor： Milton L. Lee ,  David C. Collins

IPC: H01J4900

CPC classification number: H01J49/044 ,  G01N27/622 ,  H01J49/165

Abstract: A high voltage ion propulsion field is applied across the length of an ion mobility spectrometer that is divided by a barrier wall into a desolvation region and a drift tube. A plume of ions and solvent is electrosprayed into the desolvation region, and ions are propelled from the desolvation region through the drift tube to an ion target. Drift gas flows through the drift tube in the opposite direction to oppose the ion flow. A portal in the barrier wall permits ions to move from the desolvation region into the drift tube, and restricts flow of drift gas from the drift tube into the desolvation region. The resulting drift gas velocity increase effects desolvation without requiring elevated temperature or decreased pressure. An ion gate is located near the portal and an aperture grid is located near the ion target. The drift gas flow rate is varied to change the ionization spectra to alter selectivity.

公开(公告)号：US06528784B1

公开(公告)日：2003-03-04

申请号：US09715815

申请日：2000-11-16

Applicant: Keqi Tang ,  Alan E. Schoen ,  Jean-Jacques Dunyach

Inventor： Keqi Tang ,  Alan E. Schoen ,  Jean-Jacques Dunyach

IPC: B01D5944

CPC classification number: H01J49/063 ,  H01J49/044 ,  H01J49/067

Abstract: There is described an interface for delivering ions generated in an ion source into a mass analyzer in a chamber under vacuum pressure. In particular, the interface employs two consecutive ion guides operated to dissociate adduct ions formed in the ion source or high pressure regions of the interface between the ion source and the mass analyzer, thus improving the limit of detection or limit of quantitation of the mass analyzer by increasing the analyte ion current.

Abstract translation: 描述了在真空压力下将在离子源中产生的离子输送到室中的质量分析器的界面。 特别地，界面使用两个连续的离子导向器来操作以离解形成在离子源中的加合离子或离子源和质量分析器之间的界面的高压区域，从而提高质量分析器的检测限度或定量限度 通过增加分析物离子电流。

公开(公告)号：US5663560A

公开(公告)日：1997-09-02

申请号：US555192

申请日：1995-11-08

Applicant: Minoru Sakairi ,  Tadao Mimura ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

Inventor： Minoru Sakairi ,  Tadao Mimura ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC: H01J49/04 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/044 ,  H01J49/061

Abstract: A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.

Abstract translation: 将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为 大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

公开(公告)号：US5565679A

公开(公告)日：1996-10-15

申请号：US338221

申请日：1994-11-09

Applicant: Scott D. Tanner ,  Donald J. Douglas ,  Lisa Cousins

Inventor： Scott D. Tanner ,  Donald J. Douglas ,  Lisa Cousins

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/067 ,  H01J49/044 ,  H01J49/105

Abstract: A method of analyzing an analyte contained in a plasma, in inductively coupled plasma mass spectrometry (ICP-MS). A sample of the plasma is drawn through an orifice in a sampler, then skimmed in a skimmer orifice, and the skimmed sample is directed at supersonic velocity onto a blunt reducer having a small orifice therein, forming a shock wave on the reducer. Gas in the shock wave is sampled through an offset aperture in the reducer into a vacuum chamber containing ion optics and a mass spectrometer. This reduces space charge effects, thus reducing mass bias and also reducing the mass dependency of matrix effects. Since the region between the skimmer and the reducer can operate at about 0.1 Torr, which is the same pressure as that produced by the roughing pump which backs the high vacuum pump for the vacuum chamber, a single common pump can be used for both purposes, thus reducing the hardware needed. In a simplified version, the skimmer can be replaced by a small beam blocking finger which extends across a line of sight between the sampler and reducer orifices and occludes the reducer orifice from the sampler orifice.

Abstract translation: 在电感耦合等离子体质谱（ICP-MS）中分析包含在等离子体中的分析物的方法。 等离子体的样品通过采样器中的孔被抽吸，然后在分离器孔口中被撇去，并将脱脂样品以超声速度引导到具有小孔口的钝化还原剂上，在还原剂上形成冲击波。 冲击波中的气体通过减速器中的偏移孔被采样到包含离子光学器件和质谱仪的真空室中。 这减少了空间电荷效应，从而减少了质量偏差并且还降低了矩阵效应的质量依赖性。 由于撇渣器和减速器之间的区域可以在大约0.1托的范围内工作，这是与用于真空室的高真空泵背对的粗抽泵产生的压力相同的压力，因此可以使用单个公共泵用于两个目的， 从而减少所需的硬件。 在简化版本中，撇渣器可以由小梁阻挡手指代替，该手指延伸穿过取样器和减速器孔之间的视线并且从采样器孔口封闭减速器孔口。

公开(公告)号：US5381008A

公开(公告)日：1995-01-10

申请号：US59393

申请日：1993-05-11

Applicant: Scott D. Tanner ,  Donald J. Douglas ,  Lisa Cousins

Inventor： Scott D. Tanner ,  Donald J. Douglas ,  Lisa Cousins

IPC: H01J49/04 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/067 ,  H01J49/044 ,  H01J49/105

Abstract: A method of analyzing an analyte contained in a plasma, in inductively coupled plasma mass spectrometry (ICP-MS). A sample of the plasma is drawn through an orifice in a sampler. The sample is then skimmed in a skimmer orifice, and the skimmed sample is directed at supersonic velocity onto a blunt reducer having a small orifice therein, forming a shock wave on the reducer. Gas in the shock wave is sampled through an offset aperture in the reducer into a vacuum chamber containing ion optics and a mass spectrometer. Because the gas sampled through the skimmer and reducer orifices is substantially neutral (ions and free electrons are in close proximity), and also because the reducer orifice is very small, space charge effects are reduced, thus reducing mass bias and also reducing the mass dependency of matrix effects. Separation of ions from free electrons and focusing of ions into the mass spectrometer largely occurs in and downstream of the ion optics in the vacuum chamber. Since the region between the skimmer and the reducer can operate at about 0.1 Torr, which is the same pressure as that produced by the roughing pump which backs the high vacuum pump for the vacuum chamber, a single common pump can be used for both purposes, thus reducing the hardware needed.

Abstract translation: 在电感耦合等离子体质谱（ICP-MS）中分析包含在等离子体中的分析物的方法。 等离子体的样品通过采样器中的孔抽出。 然后将样品撇取在分离器孔口中，并将脱脂样品以超声速度引导到其中具有小孔口的钝化还原剂上，在还原剂上形成冲击波。 冲击波中的气体通过减速器中的偏移孔被采样到包含离子光学器件和质谱仪的真空室中。 由于通过分离器和还原剂孔抽取的气体基本上是中性的（离子和自由电子非常接近），并且由于还原剂孔口非常小，所以空间电荷效应降低，从而减少了质量偏差并且还降低了质量依赖性 的矩阵效应。 分离离子与自由电子并将离子聚焦到质谱仪中大部分发生在真空室内离子光学器件的下游。 由于撇渣器和减速器之间的区域可以在大约0.1托的范围内工作，这是与用于真空室的高真空泵背对的粗抽泵产生的压力相同的压力，因此可以使用单个公共泵用于两个目的， 从而减少所需的硬件。

公开(公告)号：US4999493A

公开(公告)日：1991-03-12

申请号：US514658

申请日：1990-04-24

Applicant: Mark Allen ,  Ivor A. S. Lewis

Inventor： Mark Allen ,  Ivor A. S. Lewis

IPC: G01N30/72 ,  H01J49/04

CPC classification number: H01J49/165 ,  G01N30/7266 ,  G01N30/7273 ,  H01J49/044 ,  H01J49/0486

Abstract: Improved techniques are provided for forming ionized molecules from electrosprayed droplets for analysis by a mass spectrometer. A high voltage is applied to a capillary tube for spraying droplets at substantially atmospheric pressure or above, and the electrosprayed droplets contain sample solute of interest and solvent. The electrosprayed droplets are passed into an ion generating chamber which is maintained at a pressure in the range of from 0.2 Torr to 10 Torr. The walls of the ion generating chamber are controllably heated to a temperature which will desolvate the droplets and produce ionized molecules of interest for analysis by the mass spectrometer. The electrospray technique does not rely upon a countercurrent heated gas flow, and provides a particularly simple and inexpensive means to couple electrospray ionization to either quadrupole or magnetic mass analyzers.

Abstract translation: 提供了用于从电喷雾液滴形成离子化分子以进行质谱分析的改进技术。 将高电压施加到用于在基本上大气压以上喷雾液滴的毛细管，并且电喷雾的液滴含有目标溶剂和溶剂。 电喷雾的液滴进入离子产生室，其保持在0.2托至10托的压力范围内。 离子发生室的壁被可控地加热到将使液滴脱溶质并产生离子化分子的温度，由质谱仪分析。 电喷雾技术不依赖于逆流加热的气流，并且提供了将电喷雾离子化耦合到四极杆或磁性质量分析器的特别简单和便宜的手段。

公开(公告)号：US4990740A

公开(公告)日：1991-02-05

申请号：US320002

申请日：1989-03-06

Applicant: Gerhard A. Meyer

Inventor： Gerhard A. Meyer

IPC: G01N21/73 ,  H01J49/04 ,  H05H1/30

CPC classification number: H01J49/044 ,  G01N21/73 ,  H05H1/30

Abstract: An intra-microspray ICP torch for use in conjunction with spectographic analysis generates a high temperature ionized gas in a plasma region at one end of the torch, and includes a preshaped tube mounted within the torch, with a first end of the tube terminating adjacent the plasma region, and a nebulizer mounted to a second end of the tube. The preshaped tube has at least one set of impactors that define at least two chambers, the impactors blocking the line of sight between adjacent chambers. The nebulizer propels a pressurized aerosol/sample mixture at the impactors, toward the plasma region. The impactors divert the mixture as it travels from chamber to chamber toward the plasma region, causing a filtering effect that promotes passage to the plasma region of sample particles having a size of about 15 microns or less, thereby resulting in optimum spectrographic clarity.

Abstract translation: 用于与光谱分析结合使用的微内射线炬手在炬的一端处的等离子体区域中产生高温电离气体，并且包括安装在炬内的预成型管，管的第一端终止于 等离子体区域和安装到管的第二端的雾化器。 预成型管具有限定至少两个室的至少一组冲击器，冲击器阻挡相邻室之间的视线。 喷雾器将冲击器上的加压气溶胶/样品混合物推向等离子体区域。 当混合物从室到室朝向等离子体区域移动时，冲击器转移混合物，引起促进通过尺寸为约15微米或更小的样品颗粒的等离子体区域的过滤效果，从而得到最佳的光谱清晰度。