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公开(公告)号：US09824873B2
公开(公告)日：2017-11-21
申请号：US14826388
申请日：2015-08-14
Applicant: Bruker Daltonik GmbH
Inventor： Andreas Brekenfeld , Martin Engel
CPC classification number: H01J49/0486 , C03B19/12 , C04B35/14 , H01J49/0422 , H01J49/044 , H01J49/045 , H01J49/0477 , H01J49/10 , Y02P40/57
Abstract: The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material.
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公开(公告)号：US09299552B2
公开(公告)日：2016-03-29
申请号：US14640766
申请日：2015-03-06
Applicant: KABUSHIKI KAISHA TOSHIBA
Inventor： Toma Yorisaki
CPC classification number: H01J49/161 , H01J49/0409 , H01J49/0463 , H01J49/0468 , H01J49/0486 , H01J49/06 , H01J49/162
Abstract: A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, and comprising a temperature control mechanism for the sample, an ion beam irradiation device which irradiates an ion beam on the sample to generate neutral particles, a laser irradiation device which irradiates the neutral particles with a laser to obtain photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions and performs mass analysis, a driving system mirror which is provided retractably on a laser light path between the laser irradiation device and the sample table, and reflects the laser when positioned within the laser light path, and, a profiler which is arranged in a reflective direction of the driving system mirror and detects a feature of the laser.
Abstract translation: 溅射中性粒子质谱装置包括：样品台，其保持作为质谱分析对象的样品，并且包括用于样品的温度控制机构;将离子束照射在样品上以产生中性粒子的离子束照射装置; 用激光照射中性粒子以获得光激发离子的激光照射装置，吸取被引出的光激发离子并进行质量分析的质谱仪，在激光照射装置之间的激光路径上可缩回地设置的驱动系统反射镜 和样品台，并且当位于激光光路内时反射激光器，以及沿驱动系统反射镜的反射方向布置并检测激光器的特征的轮廓仪。
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3.发明授权公开(公告)号：US11728146B2
公开(公告)日：2023-08-15
申请号：US17575135
申请日：2022-01-13
Applicant: Wisconsin Alumni Research Foundation
Inventor： Michael Scott Westphall , Joshua Jacques Coon
CPC classification number: H01J49/0004 , G01N1/42 , H01J49/04 , H01J49/0468 , H01J49/0486 , H01J49/0495 , H01J49/062
Abstract: Imaging by cryo-electron microscopy (cryo-EM) requires that a sample be encased in an amorphous solid, such as amorphous ice. In current cryo-EM preparation systems, once the sample has been deposited on an EM grid and coated in the amorphous solid, the EM grid must be removed from vacuum and then transferred into the vacuum of the cryo-EM system. As a result, samples deposited on the grid are exposed to damage and contamination. The present invention provides improved EM grid handling systems and devices compatible with advanced cryo-EM sample preparation techniques and which reduce or eliminate exposure of the sample on the grid to atmosphere and elevated temperatures. These methods and devices will also significantly reduce handling time and complexities associated with cryo-EM sample preparation.
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公开(公告)号：US4730111A
公开(公告)日：1988-03-08
申请号：US832743
申请日：1986-02-24
Applicant: Marvin L. Vestal , Calvin R. Blakley
Inventor： Marvin L. Vestal , Calvin R. Blakley
CPC classification number: H01J49/049 , G01N30/7253 , H01J49/0445 , H01J49/0486 , G01N2030/3038 , G01N2030/3053 , G01N30/32
Abstract: This disclosure is concerned with method and apparatus for vaporizing liquid solutions in order to detect, quantitate, and/or determine physical or chemical properties of samples present in liquid solution. Mixtures may be separated by an on-line liquid chromatographic column and the methods used for detection, quantitation, indentification, and/or determination of chemical and physical properties include mass spectrometry, photoionization, flame ionization, electron capture, optical photemetry, including UV, visible, and IR regions of the spectrum, light scattering, light emission, atomic absorption, and any other technique suitable for detecting or analyzing molecules or particles in a gaseous or vacuum environment. The method and apparatus involves controlled partial vaporization of the solution. Methods are disclosed for controlling the degree of partial vaporization and the temperature at which this vaporization occurs, and for maintaining this degree of vaporization essentially constant even though the solvent flow rate and/or composition may vary in either a controlled or an uncontrolled fasion. This "thermospray" method and apparatus allows the solvent to be substantially vaporized to produce a supersonic free jet containing a fraction of unvaporized solvent as liquid droplets entrained in the jet. Solutes which are less volatile than the solvent are preferentially contained in the droplets. Methods are disclosed for controlling the temperature at which the process occurs in order to prevent unwanted chemical modification of the solutes (for example, pyrolysis) and to prevent premature vaporization of the solutes.
Abstract translation: 本公开涉及用于蒸发液体溶液以便检测，定量和/或确定液体溶液中存在的样品的物理或化学性质的方法和装置。 混合物可以通过在线液相色谱柱分离，用于检测，定量，鉴定和/或测定化学和物理性质的方法包括质谱法，光电离，火焰离子化，电子捕获，光学光伏，包括UV， 可见光和红外光谱区域，光散射，发光，原子吸收以及适用于在气态或真空环境中检测或分析分子或颗粒的任何其他技术。 该方法和装置包括溶液的受控部分蒸发。 公开了用于控制部分蒸发的程度和发生该蒸发的温度的方法，并且为了保持该蒸发程度基本上恒定，即使溶剂流速和/或组成可以在受控的或不受控制的过程中变化。 这种“热喷涂”方法和装置允许溶剂基本上蒸发，以产生含有一部分未蒸发溶剂的超音速自由射流，作为夹带在射流中的液滴。 比溶剂挥发性低的溶质优先包含在液滴中。 公开了用于控制过程发生温度的方法，以防止溶质的不希望的化学改性（例如热解），并防止溶质过早蒸发。
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公开(公告)号：US20150270112A1
公开(公告)日：2015-09-24
申请号：US14640766
申请日：2015-03-06
Applicant: KABUSHIKI KAISHA TOSHIBA
Inventor： Toma YORISAKI
CPC classification number: H01J49/161 , H01J49/0409 , H01J49/0463 , H01J49/0468 , H01J49/0486 , H01J49/06 , H01J49/162
Abstract: A sputter neutral particle mass spectrometry apparatus includes a sample table holding a sample which is a mass spectrometry target, and comprising a temperature control mechanism for the sample, an ion beam irradiation device which irradiates an ion beam on the sample to generate neutral particles, a laser irradiation device which irradiates the neutral particles with a laser to obtain photoexcited ions, a mass spectrometer which draws in the drawn out photoexcited ions and performs mass analysis, a driving system mirror which is provided retractably on a laser light path between the laser irradiation device and the sample table, and reflects the laser when positioned within the laser light path, and, a profiler which is arranged in a reflective direction of the driving system mirror and detects a feature of the laser.
Abstract translation: 溅射中性粒子质谱装置包括：样品台，其保持作为质谱分析对象的样品，并且包括用于样品的温度控制机构;将离子束照射在样品上以产生中性粒子的离子束照射装置; 用激光照射中性粒子以获得光激发离子的激光照射装置，吸取被引出的光激发离子并进行质量分析的质谱仪，在激光照射装置之间的激光路径上可缩回地设置的驱动系统反射镜 和样品台，并且当位于激光光路内时反射激光器，以及沿驱动系统反射镜的反射方向布置并检测激光器的特征的轮廓仪。
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Patent Agency Ranking
公开(公告)号：US20050274905A1
公开(公告)日：2005-12-15
申请号：US11155070
申请日：2005-06-16
Applicant: Timothy Joyce , Jean-Luc Truche , Jian Bai
Inventor： Timothy Joyce , Jean-Luc Truche , Jian Bai
CPC classification number: H01J49/164 , H01J49/0422 , H01J49/0477 , H01J49/0486
Abstract: The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.
Abstract translation: 本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。 离子源还可以包括温度传感器。 加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。 还公开了具有基于基质的离子源的质谱仪系统。 还提供了使用被加热到预定温度的气体产生离子的方法。
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公开(公告)号：US5196700A
公开(公告)日：1993-03-23
申请号：US798755
申请日：1991-11-27
Applicant: Norio Kameshima
Inventor： Norio Kameshima
CPC classification number: H01J49/0422 , G01N30/7206 , H01J49/0486 , H01J49/147 , G01N2030/3038 , G01N2030/6013
Abstract: An ionization chamber is separated from an ion lens system while the chamber is in contact with an interface block so that they are directly coupled in which a heater embedded in the interface block serves to heat both the interface block and the ionization chamber.
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公开(公告)号：US11776800B2
公开(公告)日：2023-10-03
申请号：US17619693
申请日：2019-06-20
Applicant: Hitachi High-Tech Corporation
Inventor： Yasuaki Takada , Shun Kumano , Masuyuki Sugiyama , Tsukasa Shishika , Shinji Yoshioka , Akimasa Osaka
CPC classification number: H01J49/0486 , H01J49/004 , H01J49/0409
Abstract: A substance analyzer that includes, to enhance selectivity of substance analysis, the following: a heater that heats a medium for collecting a chemical substance adhering to a surface of an inspection object; a mass spectrometer that performs tandem mass spectrometry of vapor derived from the chemical substance heated and vaporized by the heater from the medium; and a control device that causes the mass spectrometer to perform, based on a temperature of the medium in the heater, tandem mass spectrometry for the chemical substance that is vaporized at the temperature of the medium using the vapor sent from the heater to the mass spectrometer.
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公开(公告)号：US07372043B2
公开(公告)日：2008-05-13
申请号：US11155070
申请日：2005-06-16
Applicant: Timothy H. Joyce , Jean-Luc Truche , Jian Bai
Inventor： Timothy H. Joyce , Jean-Luc Truche , Jian Bai
IPC: H01J27/00
CPC classification number: H01J49/164 , H01J49/0422 , H01J49/0477 , H01J49/0486
Abstract: The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.
Abstract translation: 本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。 离子源还可以包括温度传感器。 加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。 还公开了具有基于基质的离子源的质谱仪系统。 还提供了使用被加热到预定温度的气体产生离子的方法。
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10.发明授权Method and means for vaporizing liquids by means of heating a sample capillary tube for detection or analysis 失效通过加热样品毛细管进行检测或分析来蒸发液体的方法和装置
公开(公告)号：US4960992A
公开(公告)日：1990-10-02
申请号：US326150
申请日：1989-03-20
Applicant: Marvin L. Vestal , Calvin R. Blakely , Gordon J. Fergusson
Inventor： Marvin L. Vestal , Calvin R. Blakely , Gordon J. Fergusson
CPC classification number: H01J49/049 , G01N30/7253 , H01J49/0445 , H01J49/0486 , G01N2030/3038 , G01N2030/3053 , G01N30/32
Abstract: This disclosure is concerned with method and apparatus for vaporizing liquid solutions in order to detect, quantitate, and/or determine physical or chemical properties of samples present in liquid solution. Mixtures may be separated by an on-line liquid chromatographic column and the methods used for detection, quantitation, identification, and/or determination of chemical and physical properties include mass spectrometry, photoionization, flame ionization, electron capture, optical photometry, including UV, visible, and IR regions of the spectrum, light scattering, light emission, atomic absorption, and any other technique suitable for detecting or analyzing molecules or particles in a gaseous or vacuum environment. The method and apparatus involves controlled partial vaporization of the solution. Methods are disclosed for controlling the degree of partial vaporization and the temperature at which this vaporization occurs, and for maintaining this degree of vaporization essentially constant even though the solvent flow rate and/or composition may vary in either a controlled or an uncontrolled fashion. ThisGOVERNMENT SUPPORTThe invention described herein was made in the course of work under a grant or award from the Department of Health and Human Services (formerly Health Education and Welfare).CROSS REFERENCE TO RELATED APPLICATIONS
Abstract translation: 本公开涉及用于蒸发液体溶液以便检测，定量和/或确定液体溶液中存在的样品的物理或化学性质的方法和装置。 混合物可以通过在线液相色谱柱分离，用于检测，定量，鉴定和/或测定化学和物理性质的方法包括质谱法，光离子化，火焰离子化，电子捕获，光学光度法，包括UV， 可见光和红外光谱区域，光散射，发光，原子吸收以及适用于在气态或真空环境中检测或分析分子或颗粒的任何其他技术。 该方法和装置包括溶液的受控部分蒸发。 公开了用于控制部分蒸发程度和发生该蒸发的温度的方法，并且为了使该蒸发程度基本上恒定，即使溶剂流速和/或组成可以以受控或不受控制的方式变化。 这种“热喷涂”方法和装置允许溶剂基本上蒸发，以产生含有一部分未蒸发溶剂的超音速自由射流，作为夹带在射流中的液滴。 比溶剂挥发性低的溶质优先包含在液滴中。 公开了用于控制过程发生温度的方法，以防止溶质的不希望的化学改性（例如热解），并防止溶质过早蒸发。
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