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公开(公告)号：US20240014020A1
公开(公告)日：2024-01-11
申请号：US18036461
申请日：2021-11-19
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Daniel CARLISLE , Michael J. LAWRENCE , Selvakumaran RAJAMANICKAM , Ali Nikbakht REZAZADEH , Edmond Chi-Chiu SIU , Greg SPRAH
IPC: H01J49/00
CPC classification number: H01J49/0009
Abstract: The technology relates to a system for improved mass analysis operation by proactively identifying contamination. The system includes a mass analysis instrument comprising mass analysis hardware components, a processor, and memory storing instructions that, when executed by the processor, cause the system to perform a set of operations. The set of operations include performing, by the mass analysis instrument at a first time, a predefined series of operational tests to produce first mass analysis results for a calibrant; performing, by the mass analysis instrument at a second time, the predefined series of operational tests to produce second mass analysis results for the calibrant; determining an analysis difference between the first mass analysis results and the second mass analysis results; and based on a magnitude of the analysis difference, generating at least one of a contamination indicator or a degradation indicator.
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公开(公告)号：US20240003846A1
公开(公告)日：2024-01-04
申请号：US18036098
申请日：2021-11-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John Lawrence Campbell , Subhasish PURKAYASTHA
IPC: G01N27/624
CPC classification number: G01N27/624
Abstract: Method for separating, detecting, and/or quantifying steroid isomers using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the method can provide for the separation of racemic or non-racemic mixtures of steroid isomers that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), including both steroid stereoisomers and constitutional steroid isomers. The method may further comprise detecting the ionized derivatized steroids transported from the differential mobility spectrometer at a first combination of compensation voltage and separation voltage and at a second combination of compensation voltage and separation voltage applied to the differential mobility spectrometer, wherein the first combination is configured to optimize transmission of a first ionized derivatized steroid corresponding to a first steroid of an isomeric steroid pair and the second combination is configured to optimize transmission of a second ionized derivatized steroid corresponding to a second steroid of the isomeric steroid pair.
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143.发明公开公开(公告)号：US20230402272A1
公开(公告)日：2023-12-14
申请号：US18032251
申请日：2021-09-14
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Eric Thomas Dziekonski
CPC classification number: H01J49/009 , H01J49/061 , H01J49/063 , H01J49/4245 , H01J49/405 , H01J49/408
Abstract: Systems and methods are disclosed for ion injection into an electrostatic trap. Various aspects of this disclosure provide a mass spectrometer system including a primary ion path including a plurality of quadrupoles; and a secondary ion path coupled to the primary ion path utilizing turning elements. The secondary ion path may include an electrostatic linear ion trap (ELIT), the ELIT being operable to analyze ions diverted from the primary ion path and return them to the primary ion path. The primary ion path may include a time-of-flight mass analyzer. The secondary ion path may be bi-directional. Ions may travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and may travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path. The secondary ion path may include a collision quadrupole.
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公开(公告)号：US20230398543A1
公开(公告)日：2023-12-14
申请号：US18035210
申请日：2021-09-30
Applicant: Aaron P. STELLA , DH Technologies Development Pte. Ltd.
Inventor： Aaron P. STELLA
CPC classification number: B01L3/5085 , B03C1/288 , B01L2200/025 , B01L2300/0829 , B01L2300/12 , B03C2201/18 , B03C2201/26
Abstract: A well tray includes a base including an upper surface, a lower surface and at least one edge surface connecting the upper surface to the lower surface. The at least one edge surface defines a slot. The slot is in communication with a magnet receiver at least partially defined between the upper surface and the lower surface. The magnet receiver is configured to slidably receive a removable magnet. The tray includes a plurality of wells disposed on an upper surface of the base.
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公开(公告)号：US20230343570A1
公开(公告)日：2023-10-26
申请号：US18016162
申请日：2021-07-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Takashi BABA , Kaoru KARASAWA
CPC classification number: H01J49/0045 , H01J49/062
Abstract: In one aspect, a method of performing mass spectrometry is disclosed, which comprises ionizing a plurality of oligonucleotides to generate a plurality of negatively charged oligonucleotide ions, and interacting a plurality of charged reagent ions with the negatively charged oligonucleotide ions to reduce the negative charge state of the negatively charged oligonucleotide ions.
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Patent Agency Ranking
公开(公告)号：US20230335384A1
公开(公告)日：2023-10-19
申请号：US17925186
申请日：2021-05-14
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Pavel RYUMIN
IPC: H01J49/02
CPC classification number: H01J49/025
Abstract: Methods and systems for identifying or classifying charge states of detected ions. An example method for classifying a charge state of detected ions may include generating a pulse for each ion in a plurality of ions detected by a detector, wherein each pulse has a pulse characteristic; generating a pulse-characteristic distribution of the generated pulses; and based on the pulse-characteristic distribution, generating an identification of the charge state of one or more ions in the plurality of ions.
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公开(公告)号：US11764052B2
公开(公告)日：2023-09-19
申请号：US17312903
申请日：2019-12-09
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Eric Thomas Dziekonski
CPC classification number: H01J49/4245 , H01J49/0031 , H01J49/426 , H01J49/482
Abstract: An ion guide defining a guide axis receives ions. The ion guide applies a potential profile that includes a pseudopotential well to the ions using an ion control field. The ion control field includes a component for restraining movement of the ions normal to the guide axis and a component for controlling the movement of the ions parallel to the guide axis. The ion guide sequentially injects the ions with the same ion energy and in decreasing order of m/z value into an ELIT aligned along an ELIT axis to focus the ions irrespective of m/z value at the same location on the ELIT axis within the ELIT at the same time by varying a magnitude of the pseudopotential well. The ELIT can trap the focused ions using in-trap potential lift or mirror-switching ion capture.
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公开(公告)号：US20230282469A1
公开(公告)日：2023-09-07
申请号：US18040774
申请日：2021-08-06
Applicant: Nic BLOOMFIELD , Gordana IVOSEV , Pavel RYUMIN , DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Nic BLOOMFIELD , Gordana IVOSEV , Pavel RYUMIN
IPC: H01J49/00
CPC classification number: H01J49/0036
Abstract: A method for assigning charge state in mass spectrometry includes receiving a detector response signal corresponding to a plurality of ion arrival events. The detector response signal includes information related to individual ion responses generated by a detector for each ion arrival event. Detector response profiles are generated for mass-to-charge (m/z) bins of a mass spectrum generated from the ion arrival events based on the detector response signal. The m/z bins are grouped into a plurality of groups based on a similarity of the detector response profiles of the m/z bins. A charge state is assigned to one or more features based on the groups of m/z bins.
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公开(公告)号：US20230238230A1
公开(公告)日：2023-07-27
申请号：US17999814
申请日：2021-05-25
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. COVEY , Chang LIU
CPC classification number: H01J49/0413 , H01J49/165 , B25J15/0052
Abstract: Technology for analyzing collections of substance samples. Systems in accordance with the disclosure can include one or more sample handlers, sample capture devices, mass analysis instruments, and controllers; the controllers being operative, in accordance with instructions received from at least one of an operator input device and machine-interpretable instructions stored in memory accessible by the controller, to generate signals configured to cause the sample handler to collectively retrieve from a sample source a plurality of samples of one or more substances, and deliver the plurality of collected samples to the at least one sample capture device; cause the sample capture device to independently capture at least one of the collectively retrieved samples delivered by the sample handler, and transfer the at least one captured sample to a mass analysis instrument; and cause the mass analysis instrument to ionize and detect one or more particles of the transferred treated sample.
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公开(公告)号：US20230236189A1
公开(公告)日：2023-07-27
申请号：US18151974
申请日：2023-01-09
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Subhasish Purkayastha , Subhakar Dey
CPC classification number: G01N33/569 , C12Q1/02 , G01N30/72 , C12Q1/68 , C12Q1/04 , C12Q1/686 , G01N30/7233 , G01N30/88 , G01N33/6848 , G01N2030/8831
Abstract: Systems and methods are provided for microbial identification using cleavable tags. Control information is sent to a mass spectrometer to fragment one or more nucleic acid primers labeled with a first tag and monitor for an intensity of the first tag in a mass spectrometry (MS) method. An ion source provides a beam of ions from a polymerase chain reaction amplified sample that includes one or more nucleic acid primers labeled with the first tag. The first tag binds to one or more nucleic acid primers of a known microbe and is cleaved from the nucleic acid primers during the MS method. The mass spectrometer receives the beam of ions and is adapted to perform the MS method on the beam of ions. If the intensity of the first tag received from the mass spectrometer exceeds a threshold value, the known microbe is identified in the sample.
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