公开(公告)号：US08314377B2

公开(公告)日：2012-11-20

申请号：US12645542

申请日：2009-12-23

Applicant: Curt Binner

Inventor： Curt Binner

IPC: G01J1/42

CPC classification number: A61B1/24 ,  A61B1/00165 ,  A61B1/0646 ,  A61B1/0676 ,  A61B5/0088 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/0846

Abstract: The present invention regards methods and devices for detecting plaque on a surface in the oral cavity to which a fluorescent agent capable of binding to plaque has been applied, whereby a radiation source emits incident radiation for contacting the surface, reflected light and fluorescent emission resulting from contact of the radiation with the surface is collected by an optical collector and conveyed by an optical pathway in the device, where the optical light signal of the reflected light and fluorescent emission is converted to an electrical signal, and where the electrical signals of the fluorescent emission and the reflected light are then mathematically manipulated to provide a compensated plaque value as a function of the distance from the optical collector and the surface of the oral cavity to which the fluorescent agent has been applied.

Abstract translation: 本发明涉及用于在口腔内表面上检测斑块的方法和装置，其中已经施加能够结合斑块的荧光剂，由此辐射源发射用于接触表面的入射辐射，反射光和由 辐射与表面的接触由光学收集器收集并通过设备中的光学路径传送，其中反射光和荧光发射的光学信号被转换为电信号，并且其中荧光 然后数学地操作发射和反射光，以提供作为与光学收集器和已经施加荧光剂的口腔表面的距离的函数的补偿的斑块值。

公开(公告)号：US20120206727A1

公开(公告)日：2012-08-16

申请号：US13370969

申请日：2012-02-10

Applicant: Alfons Schulte ,  Silki Arora

Inventor： Alfons Schulte ,  Silki Arora

IPC: G01J3/46

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G01N21/314 ,  G01N21/3151 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2201/0627 ,  G01N2201/0846 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/26 ,  G02B21/367

Abstract: Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a confocal microscope. Spatial resolution better than 1.4 μm in the lateral and 3.6 μm in the axial, directions was obtained. The detection and measurement of the absorption spectrum of hemoglobin in a single red blood cell under physiological conditions on the timescale of seconds was realized. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, and other areas.

Abstract translation: 用微米尺度测量空间分辨率的光吸收光谱的装置和方法。 示例性设置将透射几何中的连续白光激发光束与共聚焦显微镜组合。 获得横向分辨率优于1.4μm，轴向方向为3.6μm。 实现了在生理条件下单次红细胞血红蛋白吸收光谱在秒的时间刻度上的检测和测量。 该装置和方法能够调查微尺度上小样品的光密度的空间变化以及在单细胞水平上对生物组装的研究，导致在光学诊断，微流体等领域的应用。

公开(公告)号：US08030094B2

公开(公告)日：2011-10-04

申请号：US12834422

申请日：2010-07-12

Applicant: David R. Walt ,  Todd A. Dickinson

Inventor： David R. Walt ,  Todd A. Dickinson

IPC: G01N33/543 ,  G01N21/00 ,  G01N21/75

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US20110085165A1

公开(公告)日：2011-04-14

申请号：US12899055

申请日：2010-10-06

Applicant: Jeff Beckstead ,  Matthew Nelson ,  Patrick Treado

Inventor： Jeff Beckstead ,  Matthew Nelson ,  Patrick Treado

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/10 ,  G01J3/28 ,  G01J3/36 ,  G01J3/44 ,  G01J3/443 ,  G01N21/65 ,  G01N21/718 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: A system and method for detection and identification of unknown samples using a combination of Raman and LIBS detection techniques. A first region of a sample and a second region of a sample are illuminated using structured illumination to thereby generate a first plurality of interacted photons and a second plurality of interacted photons. This first plurality and second plurality of interacted photons may be passed through a fiber array spectral translator device. Said first plurality of interacted photons are assessed using Raman spectroscopy to thereby generate a Raman data set. Said second plurality of interacted photons are assessed using LIBS spectroscopy to thereby generate LIBS data set. These data sets may be analyzed to identify the sample. These data sets may also be fused for further analysis.

Abstract translation: 一种使用拉曼和LIBS检测技术的组合检测和识别未知样品的系统和方法。 使用结构照明来照射样品的第一区域和样品的第二区域，从而产生第一多个相互作用的光子和第二多个相互作用的光子。 该第一多个和第二多个相互作用的光子可以通过光纤阵列光谱转换器装置。 使用拉曼光谱来评估所述第一多个相互作用的光子，从而产生拉曼数据集。 使用LIBS光谱来评估所述第二多个相互作用的光子，从而生成LIBS数据集。 可以分析这些数据集以识别样品。 这些数据集也可以融合进一步分析。

公开(公告)号：US20110063624A1

公开(公告)日：2011-03-17

申请号：US12672203

申请日：2008-10-10

Applicant: Yukio Ueda ,  Yutaka Yamashita

Inventor： Yukio Ueda ,  Yutaka Yamashita

IPC: G01N21/17

CPC classification number: G01N21/4795 ,  A61B5/0091 ,  A61B5/4312 ,  G01N2201/0846

Abstract: A bioinstrumentation apparatus irradiates light onto a measured region of a subject, detects diffused light to acquire internal information on the measured region, and includes: a container holding a light transmitting medium; a light irradiation unit including a plurality of light emitting ends fixed to the container and irradiating a first light and a second light that mutually differ in wavelength onto the measured region that is immersed in the medium; a light detection unit including a plurality of light detecting ends fixed to the container and detecting the diffused light from the measured region; and a computing unit computing the internal information based on an output signal from the light detection unit; the wavelength of the first light being a wavelength at which an absorption coefficient of the measured region and a mean value of absorption coefficient of the medium are substantially equal, the wavelength of the second light being a wavelength at which the absorption coefficient of the measured region is greater than the mean value of the absorption coefficient of the medium, and the computing unit computing the internal information based on an output signal related to diffused light of the first light and computing boundary information between the measured region and the medium based on an output signal related to diffused light of the second light.

Abstract translation: 生物测定装置将光照射到被检测体的测定区域，检测漫射光以获取测量区域的内部信息，并且包括：保持透光介质的容器; 光照射单元，其包括固定到所述容器的多个发光端，并且将相对不同波长的第一光和第二光照射到浸没在所述介质中的所述测量区域上; 光检测单元，其包括多个光检测端，固定到所述容器并检测来自所述测量区域的漫射光; 以及计算单元，基于来自所述光检测单元的输出信号来计算所述内部信息; 所述第一光的波长是所述测定区域的吸收系数和所述介质的吸收系数的平均值基本相等的波长，所述第二光的波长为所述测定区域的吸收系数的波长 大于所述介质的吸收系数的平均值，并且所述计算单元基于与所述第一光的漫射光相关的输出信号和基于所述测量区域与所述介质之间的计算边界信息的输出来计算所述内部信息 与第二光的漫射光有关的信号。

公开(公告)号：US07855780B1

公开(公告)日：2010-12-21

申请号：US12139015

申请日：2008-06-13

Applicant: Nicholas Djeu

Inventor： Nicholas Djeu

IPC: G01N21/65 ,  G01N21/35

CPC classification number: G01N21/65 ,  G01N21/3577 ,  G01N21/552 ,  G01N2021/1734 ,  G01N2021/8528 ,  G01N2201/0846 ,  G01N2201/088

Abstract: Disclosed is a spectroscopic system having a fiber-optic probe for simultaneous IR and Raman measurement. The probe includes a single strand of optical fiber, such as sapphire which is suitable for IR absorption measurements as far as 4 μm and Raman excitation at wavelengths as short as 300 nm. The probe is immersed in the sample and functions in the evanescent wave mode for both IR absorption and Raman scattering measurements. The sensing system makes possible the synergistic, and simultaneous, analysis of both IR and Raman data in an integrated device.

Abstract translation: 公开了一种具有用于同时IR和拉曼测量的光纤探针的光谱系统。 该探头包括单股光纤，例如蓝宝石，其适合于至多4μm的IR吸收测量和在短于300nm的波长下的拉曼激发。 将探针浸入样品中，并以ev逝波模式进行红外吸收和拉曼散射测量。 感测系统使得集成器件中IR和拉曼数据的协同和同时分析成为可能。

公开(公告)号：US07848605B2

公开(公告)日：2010-12-07

申请号：US12185224

申请日：2008-08-04

Applicant: Trent Ridder ,  Ben ver Steeg ,  Mike Mills

Inventor： Trent Ridder ,  Ben ver Steeg ,  Mike Mills

IPC: G02B6/44

CPC classification number: G01N21/49 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0233 ,  A61B2562/046 ,  A61B2562/12 ,  G01N21/474 ,  G01N21/4795 ,  G01N2021/4745 ,  G01N2201/0846 ,  Y10S385/901

Abstract: An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product. Methods of making such probes are described.

Abstract translation: 一种用于非侵入性测量受试者的生物样品中的分析物质的光学探针包括将源光从光学探针输入传送到样品界面的多个照明纤维，多个收集纤维，其将从 样品接口连接到光学探针输出，并且其中照明和收集光纤基本上垂直于样品界面定向，并且照明和收集光纤以多个线性行堆叠以提供以矩形图案布置的纤维堆叠。 光学探针适合于与商业产品一致的尺寸制造。 描述制造这种探针的方法。

公开(公告)号：US20100281972A1

公开(公告)日：2010-11-11

申请号：US12445865

申请日：2007-10-16

Applicant: Gert Krammer

Inventor： Gert Krammer

IPC: G01F23/292

CPC classification number: G01F23/292 ,  G01D5/35303 ,  G01N21/00 ,  G01N21/4133 ,  G01N2201/0846

Abstract: A method and a device for optically determining state variables inside a container (1) for liquefied gases. In the method and device, light emitted by an illumination unit (2) travels within an optical waveguide (7, 9) to a contact point (33) with the content of the container (1) and is partially reflected there, the intensity of the reflected light is measured by an image sensor (4), and a state variable is determined from the intensity. In order to create a comprehensive “image” of the state variables in the container and of the container content, several optical waveguides (29, 29′) are guided to contact points (33) which are distributed within the container (1) and form measurement points (9.1, 9.2, 9.3, . . . , 9.n). Locally assigned state variables (refractive index, density, temperature, etc.) of the container content are determined from the measured values obtained at the measurement points (9.1, 9.2, 9.3, . . . , 9.n) and are evaluated along with the spatial coordinates of the measurement points (9.1, 9.2, 9.3, . . . , 9.n) in the container (1).

Abstract translation: 一种用于光学地确定用于液化气体的容器（1）内的状态变量的方法和装置。 在该方法和装置中，由照明单元（2）发射的光在容器（1）的内容物的光波导（7,9）内移动到接触点（33），并在其上部分反射， 反射光由图像传感器（4）测量，并根据强度确定状态变量。 为了创建容器和容器内容中的状态变量的综合“图像”，几个光波导（29,29'）被引导到分配在容器（1）内的接触点（33）并形成 测量点（9.1，9.2，9.3，...，9.n）。 从测量点（9.1,9.2,9.3，...，9.n）获得的测量值确定容器含量的局部分配状态变量（折射率，密度，温度等），并与 容器（1）中的测量点（9.1,9.2,9.3，...，9.n）的空间坐标。

公开(公告)号：US20100267092A1

公开(公告)日：2010-10-21

申请号：US12703037

申请日：2010-02-09

Applicant: Frederic ZENHAUSERN ,  Alan Nordquist ,  Ralf Lenigk ,  Cedric Hurth ,  Jianing Yang ,  Xiaojia Chen ,  Matthew Estes ,  John Lee-Edghill ,  Nina Moran ,  Andrew Hopwood ,  Pieris Koumi ,  Zhi Cai

Inventor： Frederic ZENHAUSERN ,  Alan Nordquist ,  Ralf Lenigk ,  Cedric Hurth ,  Jianing Yang ,  Xiaojia Chen ,  Matthew Estes ,  John Lee-Edghill ,  Nina Moran ,  Andrew Hopwood ,  Pieris Koumi ,  Zhi Cai

IPC: C12P19/34 ,  C12M1/36 ,  C12M1/00 ,  G01N33/48 ,  B65G53/66

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

Abstract translation: 提供了一种方法和设备结构，其使得能够相对于在其中提供诸如PCR的一系列过程的设备来收集和分离归档样本。 提供了一种室结构和使用方法，其中通过控制通过各种通道的相对阻力获得受控和精确的体积。

公开(公告)号：US20090164130A1

公开(公告)日：2009-06-25

申请号：US11917023

申请日：2006-06-09

Applicant: Anand T. N. Kumar ,  David Alan Boas ,  Adrew K. Dunn

Inventor： Anand T. N. Kumar ,  David Alan Boas ,  Adrew K. Dunn

IPC: G01N21/64 ,  G06F19/00

CPC classification number: G01N21/6456 ,  G01N21/39 ,  G01N21/4795 ,  G01N21/6408 ,  G01N2021/1787 ,  G01N2201/0697 ,  G01N2201/0846 ,  G01N2201/103

Abstract: Methods, apparatus (100), and computer program products for determining lifetimes and distribution of fluorophores (102) embedded in samples (104). Fluorophores are placed into the sample, light from a source (110) selected to excite the fluorophores illuminates the sample, light emitted from the excited fluorophores is detected by a device (138), and a time-domain analysis is performed on the detected emitted light to determine a three-dimensional distribution of the fluorophores in the sample.

Abstract translation: 用于确定嵌入样品（104）中的荧光团（102）的寿命和分布的方法，装置（100）和计算机程序产品。 将荧光团放置在样品中，来自选择用于激发荧光团的源（110）的光照射样品，由装置（138）检测从激发的荧光团发射的光，并且对所检测到的发射 以确定样品中荧光团的三维分布。