公开(公告)号：US20110120212A1

公开(公告)日：2011-05-26

申请号：US12935349

申请日：2009-03-31

Applicant: Hans Joergen Pedersen ,  Kasper Mayntz Paasch ,  Holger Dirac

Inventor： Hans Joergen Pedersen ,  Kasper Mayntz Paasch ,  Holger Dirac

IPC: G01N21/84

CPC classification number: A61B5/1459 ,  A61B5/14532 ,  A61B5/6848 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/653 ,  G01N2201/08

Abstract: A system (1) for optically determining a concentration of a substance of interest, e.g. glucose, in a body fluid. The system (1) comprises a probe head (2) adapted to be positioned in direct contact with a body fluid to be analysed, e.g. subcutaneously, in a blood vessel or in direct contact with a sample. The probe head (2) defines an analysis volume (5) which is at least partly delimited towards the body fluid by a semi-permeable membrane (6) allowing substances of interest to enter the analysis volume (5). The system (1) further comprises first light guiding means (7) arranged for guiding primary light (9) to the analysis volume (5), and second light guiding means (8) arranged for guiding secondary light (11) away from the analysis volume (5). The primary light (9) is scattered, preferably Raman scattered, and the scattered spectrum is used for determining the concentration of the substance of interest.

Abstract translation: 一种用于光学确定感兴趣物质的浓度的系统（1），例如， 葡萄糖，体液。 系统（1）包括探针头（2），其适于定位成与待分析的体液直接接触。 皮下，在血管中或与样品直接接触。 探针头（2）限定分析体积（5），其通过允许感兴趣物质进入分析体积（5）的半透膜（6）至少部分地朝向体液界定。 系统（1）还包括布置成将初级光（9）引导到分析体积（5）的第一导光装置（7）和布置成用于将二次光（11）引导离开分析的第二导光装置（8） 卷（5）。 主光（9）散射，优选拉​​曼散射，散射光谱用于确定感兴趣物质的浓度。

公开(公告)号：US20110079705A1

公开(公告)日：2011-04-07

申请号：US12775391

申请日：2010-05-06

Applicant: Austin B. Tomaney ,  Mark F. Oldham

Inventor： Austin B. Tomaney ,  Mark F. Oldham

IPC: H01L27/146

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/121 ,  H04N5/225 ,  H04N5/357 ,  H04N5/361 ,  H04N5/367

Abstract: A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.

Abstract translation: 用于表征与适用于生物分析的电荷耦合器件相关的信号噪声的贡献的系统和方法。 暗电流贡献，读出偏移贡献，光响应不均匀性和杂散电荷贡献可以由本教导的方法确定并用于本教导的系统的信号校正。

公开(公告)号：US07916298B2

公开(公告)日：2011-03-29

申请号：US12655734

申请日：2009-12-14

Applicant: Norimasa Yamamoto

Inventor： Norimasa Yamamoto

IPC: G01N21/00

CPC classification number: G01N35/025 ,  G01N21/253 ,  G01N21/255 ,  G01N21/272 ,  G01N2201/08

Abstract: This analyzer comprises a photoirradiation portion simultaneously photoirradiating a plurality of storage vessels storing a plurality of measurement samples respectively and a plurality of photodetection portions detecting a plurality of light components resulting from simultaneous photoirradiation on the plurality of storage vessels storing the plurality of measurement samples respectively. The photoirradiation portion includes a light source, a first light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively and a second light guide portion branching light emitted from the light source into a plurality of light components and guiding the plurality of light components to the plurality of measurement samples respectively.

Abstract translation: 该分析仪包括同时对存储多个测量样本的多个存储容器进行光照射的光照射部分和分别检测在存储多个测量样本的多个存储容器上同时进行光照射而产生的多个光分量的多个光电检测部分。 光照射部分包括光源，将从光源发射的光分成多个光分量并将多个光分量引导到多个测量样本的第一光导部分和分别从多个光分量发射的光的第二导光部分 所述光源分成多个光分量，并将所述多个光分量分别引导到所述多个测量样本。

公开(公告)号：US20110062318A1

公开(公告)日：2011-03-17

申请号：US12792073

申请日：2010-06-02

Applicant: Charles-Etienne Bisaillon ,  Guy Lamouche ,  Marc L. Dufour

Inventor： Charles-Etienne Bisaillon ,  Guy Lamouche ,  Marc L. Dufour

IPC: G12B13/00 ,  B05D3/10 ,  G01D18/00

CPC classification number: G01N21/4785 ,  A61B5/00 ,  A61B2560/0228 ,  A61B2560/0233 ,  G01N21/59 ,  G01N2201/08 ,  G01N2201/127 ,  G09B23/285 ,  G09B23/286

Abstract: A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighbouring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.

Abstract translation: 用于制造多层组织体模的方法包括连续地形成至少两层，每层通过在支撑元件上沉积粘性可流动材料形成，或者由预先形成的由支撑元件支撑的体模层形成，选择性地重新分配材料，同时材料 正在凝固以控制该层的厚度分布，并允许该材料足够固化以施加下一层。 支撑元件以2或3个方向支撑材料，并有效地模制组织的内腔。 相邻的层具有不同的组成和选定的厚度以提供所需的光学性质和体模的机械性能。 幻影可以选择衰减和后向散射特性来模拟组织用于光学相干断层成像。

公开(公告)号：US07886821B2

公开(公告)日：2011-02-15

申请号：US12019452

申请日：2008-01-24

Applicant: Rocco DiFoggio

Inventor： Rocco DiFoggio

IPC: E21B49/00

CPC classification number: E21B49/10 ,  E21B47/01 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/10 ,  G01J3/44 ,  G01N21/09 ,  G01N21/11 ,  G01N21/3577 ,  G01N21/65 ,  G01N2201/08 ,  G01V8/02

Abstract: A downhole fluid sample container includes a fluid sample container detachably coupled to a downhole sub, the fluid sample container having an internal chamber for receiving the downhole fluid. At least one semimetal (for example, silicon or germanium) window is coupled to the fluid sample container, the window being substantially transparent to electromagnetic energy wavelengths within a selected band. A method includes transmitting electromagnetic energy from an electromagnetic energy source to downhole fluid through at least one semimetal window in a container, receiving an electromagnetic energy response with a spectrometer, and estimating the downhole fluid property based at least in part on the electromagnetic energy response.

Abstract translation: 井下流体样品容器包括可拆卸地联接到井下sub的流体样品容器，流体样品容器具有用于接收井下流体的内部室。 至少一个半金属（例如，硅或锗）窗口耦合到流体样品容器，该窗对于选定的带内的电磁能量波长基本上是透明的。 一种方法包括：通过容器中的至少一个半金属窗口将电磁能量从电磁能源传输到井下流体，利用光谱仪接收电磁能量响应，以及至少部分地基于电磁能量响应来估计井下流体特性。

公开(公告)号：US07741598B2

公开(公告)日：2010-06-22

申请号：US12402901

申请日：2009-03-12

Applicant: Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

Inventor： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

IPC: G01J1/04 ,  G01J1/58

CPC classification number: G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

Abstract translation: 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

公开(公告)号：US07729582B2

公开(公告)日：2010-06-01

申请号：US12097789

申请日：2007-12-07

Applicant: Ville Laitala ,  Pauli Salmelainen

Inventor： Ville Laitala ,  Pauli Salmelainen

IPC: G02B6/44

CPC classification number: G02B6/04 ,  G01N21/251 ,  G01N21/76 ,  G01N2201/08

Abstract: The present technology relates generally to fibre optic cables their manufacture and uses in the field of optical measurements including biochemical laboratory instrumentation for measuring properties of samples on microtitration plates and corresponding sample supports. The technology has also applications in various laser technologies. A fibre optic cable has an active surface with a determined form provided at a first optical interface at the first end of the cable. The first end of the cable is fused into an exemplary circular form, the fused cable end including fibre ends both within the active surface and outside the active surface. At the opposite, second end of the cable, those fibres which have their first ends at the determined active surface area, are used for forming a second optical interface. It is possible to have high transmission efficiency in optical interfaces where other than circular cross section of the light beam exists.

Abstract translation: 本技术一般涉及其在光学测量领域中的制造和应用的光纤电缆，包括用于测量微量滴定板上的样品和相应样品载体的性质的生化实验室仪器。 该技术也可应用于各种激光技术。 光纤电缆具有在电缆的第一端处的第一光学接口处设置的具有确定形式的有源表面。 电缆的第一端被熔合成示例性的圆形形式，熔化的电缆端部包括在活动表面内部和活动表面之外的光纤端部。 在电缆的相对的第二端，将其第一端在确定的有效表面积处的那些纤维用于形成第二光学界面。 在存在光束的圆形截面的光接口中，可以具有高的传输效率。

公开(公告)号：US07595889B2

公开(公告)日：2009-09-29

申请号：US11548468

申请日：2006-10-11

Applicant: Adam Wax ,  John W. Pyhtila

Inventor： Adam Wax ,  John W. Pyhtila

IPC: G01B9/02 ,  G01J3/45 ,  G01B11/02

CPC classification number: G01J3/4412 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/7257 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01J3/4531 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Abstract translation: 傅里叶域a / LCI（faLCI）系统和方法，使用单次扫描能够以快速的速率进行体内数据采集。 通过一次扫描获得角度分辨和深度分辨的光谱信息。 由于仅需要一次扫描，参考臂可以相对于样品保持固定。 参考信号和反射的采样信号以相对于样本的多个反射角度相互相关并分散，从而同时并行地表示来自样品上的多个点的反射。 可以通过大约40毫秒量级的一次扫描获得关于样本上多个不同点的每个样本的所有深度的信息。 从空间相互关联的参考信号，也可以使用允许从角度分辨数据获得散射体的尺寸信息的技术来获得结构（尺寸）信息。

公开(公告)号：US07595473B2

公开(公告)日：2009-09-29

申请号：US11209432

申请日：2005-08-22

Applicant: David R. Walt ,  Sandra Bencic-Nagale

Inventor： David R. Walt ,  Sandra Bencic-Nagale

IPC: G01N21/00

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J2001/0276 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/088

Abstract: The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.

Abstract translation: 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。

公开(公告)号：US20090230028A1

公开(公告)日：2009-09-17

申请号：US12403005

申请日：2009-03-12

Applicant: Beno Mueller ,  Bertram Beigel

Inventor： Beno Mueller ,  Bertram Beigel

IPC: G01N15/04 ,  G02B6/032 ,  G02B6/00

CPC classification number: G02B6/032 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2201/08 ,  G02B2006/0325

Abstract: A fluid conduit comprises an inner conduit configured for conducting a fluid, and an outer conduit circumferentially enclosing the inner conduit. The outer conduit's inner diameter is larger than the inner conduit's outer diameter, with an interspace being formed between the inner conduit's outer surface and the outer conduit's inner surface. The interspace between the inner conduit's outer surface and the outer conduit's inner surface contains an interspace liquid. The inner conduit is configured for guiding light coupled into the inner conduit, and dependent on the light's angle of incidence, total reflection occurs at a boundary between the inner conduit's outer surface and the interspace between the inner conduit and the outer conduit.

Abstract translation: 流体导管包括构造成用于传导流体的内导管和周向包围内导管的外导管。 外导管的内径大于内导管的外径，在内导管的外表面和外导管的内表面之间形成间隙。 内导管的外表面和外导管的内表面之间的间隙包含间隙液体。 内导管构造成用于引导耦合到内导管中的光，并且取决于光的入射角，在内导管的外表面和内导管与外导管之间的间隙的边界处发生全反射。