公开(公告)号：US07916291B2

公开(公告)日：2011-03-29

申请号：US12614281

申请日：2009-11-06

Applicant: Thomas D. Milster ,  Pramod Kumar Khulbe ,  Barry Gelernt

Inventor： Thomas D. Milster ,  Pramod Kumar Khulbe ,  Barry Gelernt

IPC: G01J3/44

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/024 ,  G01J3/2823 ,  G01J3/44 ,  G02B21/16

Abstract: Apparatuses and methods for performing spectroscopy and optical microscopy are disclosed. In at least one embodiment, a Raman spectrometer includes a vacuum ultraviolet light source configured to generate light having a wavelength within a window in the vacuum ultraviolet region of the electromagnetic spectrum within which a local minimum in the absorption coefficient of Oxygen occurs. The spectrometer also includes a lens device that receives a first portion of the generated light, directs at least some of the first portion of the generated light toward a target location, receives reflected light from the target location, and directs the reflected light toward a further location. The spectrometer further includes a dispersive device that receives at least some of the reflected light and outputs dispersed light produced based thereupon, and a camera module that is positioned at additional location, where the camera module receives at least some of the dispersed light.

Abstract translation: 公开了用于执行光谱和光学显微镜的装置和方法。 在至少一个实施例中，拉曼光谱仪包括真空紫外光源，其被配置为产生在电磁光谱的真空紫外区域内具有波长的光的光，其中发生氧吸收系数的局部最小值。 光谱仪还包括接收所产生的光的第一部分的透镜装置，将所产生的光的第一部分中的至少一部分导向目标位置，接收来自目标位置的反射光，并将反射光引向另一个 位置。 光谱仪还包括分散装置，其接收至少一些反射光并输出基于其产生的分散光;以及相机模块，其位于附加位置处，其中相机模块接收至少一些分散的光。

公开(公告)号：US20110037978A1

公开(公告)日：2011-02-17

申请号：US12779368

申请日：2010-05-13

Applicant: Sven SCHOENFELDER ,  Andreas BABLICH ,  Dirk BAXMANN ,  Robert James KENNEDY

Inventor： Sven SCHOENFELDER ,  Andreas BABLICH ,  Dirk BAXMANN ,  Robert James KENNEDY

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/44 ,  G02B21/0032 ,  G02B21/0076

Abstract: For investigating the spectrum of emission radiation excited in an object by incident radiation, miniaturised spectrometers are known for mobile use. These devices comprise a light source with perforated shutter, an illuminating beam path, a detecting beam path and a spectrometer.For the miniaturised spectrometer according to the invention, a diode laser is preferably used as an edge emitter (without a perforated shutter). The window of the edge emitter is arranged at the focal point of the converging lens at the input of the illuminating beam path (without an optical fibre), preferably without a perforated shutter. The edge emitter produces a divergent beam pencil with an elliptical cross-section. The length ratio of the main axes of the ellipse is more than 2:1. The large main axis of the ellipse runs parallel to the longitudinal axis of the entry slit of the microspectrometer.The miniaturised spectrometer has a reduced size and an increased sensitivity for emission radiation of low intensity. The excitation radiation subjects the object to little loading. Objects in the micro litre or milligram range can be investigated under gentle conditions.

Abstract translation: 为了研究通过入射辐射在物体中激发的发射辐射的光谱，已知小型化的光谱仪用于移动使用。 这些装置包括具有多孔快门的光源，照明光束路径，检测光束路径和光谱仪。 对于根据本发明的小型化的光谱仪，优选使用二极管激光器作为边缘发射器（没有穿孔的快门）。 边缘发射器的窗口布置在会聚透镜的焦点处的照明光束路径的输入处（无光纤），优选地没有穿孔的快门。 边缘发射器产生具有椭圆形横截面的发散光束笔。 椭圆的主轴长度比大于2：1。 椭圆的大主轴线平行于显微光谱仪的入口狭缝的纵向轴线延伸。 小型化光谱仪具有减小的尺寸和增加的低强度发射辐射的灵敏度。 激发辐射使物体几乎不加载。 在微升或毫克范围内的物体可以在温和的条件下进行研究。

公开(公告)号：US07886821B2

公开(公告)日：2011-02-15

申请号：US12019452

申请日：2008-01-24

Applicant: Rocco DiFoggio

Inventor： Rocco DiFoggio

IPC: E21B49/00

CPC classification number: E21B49/10 ,  E21B47/01 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/10 ,  G01J3/44 ,  G01N21/09 ,  G01N21/11 ,  G01N21/3577 ,  G01N21/65 ,  G01N2201/08 ,  G01V8/02

Abstract: A downhole fluid sample container includes a fluid sample container detachably coupled to a downhole sub, the fluid sample container having an internal chamber for receiving the downhole fluid. At least one semimetal (for example, silicon or germanium) window is coupled to the fluid sample container, the window being substantially transparent to electromagnetic energy wavelengths within a selected band. A method includes transmitting electromagnetic energy from an electromagnetic energy source to downhole fluid through at least one semimetal window in a container, receiving an electromagnetic energy response with a spectrometer, and estimating the downhole fluid property based at least in part on the electromagnetic energy response.

Abstract translation: 井下流体样品容器包括可拆卸地联接到井下sub的流体样品容器，流体样品容器具有用于接收井下流体的内部室。 至少一个半金属（例如，硅或锗）窗口耦合到流体样品容器，该窗对于选定的带内的电磁能量波长基本上是透明的。 一种方法包括：通过容器中的至少一个半金属窗口将电磁能量从电磁能源传输到井下流体，利用光谱仪接收电磁能量响应，以及至少部分地基于电磁能量响应来估计井下流体特性。

公开(公告)号：US20110026019A1

公开(公告)日：2011-02-03

申请号：US12933001

申请日：2009-03-20

Applicant: Som Tyagi ,  Kambiz Pourrezaei

Inventor： Som Tyagi ,  Kambiz Pourrezaei

IPC: G01N21/65 ,  B82Y20/00 ,  B05D5/00

CPC classification number: G01N21/658 ,  G01J3/44 ,  Y10T428/24372 ,  Y10T428/24413

Abstract: A method for the formation of surface enhanced Raman scattering substrates. The method produces thin substrates that have a nanoparticle ink deposited thereon. The nanoparticle ink may be any suitable nanoparticle ink such as silver, gold or copper nanoparticle ink which includes stabilized nanoparticles. The substrates and nanoparticle ink undergo a first step of heating in order to remove liquid vehicle from the ink. The substrates and nanoparticles then undergo a second step of heating for an amount of time sufficient to remove a substantial portion of the stabilizer and provide a fractal aggregate nanoparticle layer on the substrate having a certain resistivity or conductivity suitable for Raman scattering. This creates SERS substrates with enhanced amplification properties.

Abstract translation: 一种形成表面增强拉曼散射基板的方法。 该方法产生沉积有纳米颗粒油墨的薄基材。 纳米颗粒油墨可以是任何合适的纳米颗粒油墨，例如包括稳定的纳米颗粒的银，金或铜纳米颗粒油墨。 底物和纳米颗粒油墨经历第一步加热以从油墨中除去液体载体。 衬底和纳米粒子然后进行第二步骤的加热足够的时间以去除大部分的稳定剂，并在衬底上提供适合于拉曼散射的一定电阻率或电导率的分形聚集体纳米颗粒层。 这产生具有增强扩增性能的SERS底物。

公开(公告)号：US07869051B2

公开(公告)日：2011-01-11

申请号：US12016711

申请日：2008-01-18

Applicant: James L. Thomas ,  Wolfgang G. Ruldolph ,  Xuejun Liu

Inventor： James L. Thomas ,  Wolfgang G. Ruldolph ,  Xuejun Liu

IPC: G01B9/02 ,  G01J3/45 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01N21/31 ,  G01N2021/3155 ,  G01N2021/3185

Abstract: The present invention includes a system and method for coherent imaging. The system of the present invention includes a light source adapted to provide coherent light to illuminate a sample resulting in optically mixed coherent signals and a detector adapted to receive the optically mixed coherent signals and produce an output signal in response thereto. The optically mixed coherent signals will be a set of sum and difference frequency combinations of the frequencies in the coherent light. A processor is connected to the detector and adapted to ratio a selected two of the optically mixed coherent signals in response to the output signal received by the detector and to generate an image in response to the ratioed optically mixed coherent signals, which can be displayed for a user.

Abstract translation: 本发明包括用于相干成像的系统和方法。 本发明的系统包括适于提供相干光以照亮产生光学混合相干信号的样本的光源，以及适于接收光学混合相干信号并响应于此产生输出信号的检测器。 光学混合的相干信号将是相干光中的频率的和和差频组合的集合。 处理器连接到检测器并且适于响应于由检测器接收的输出信号来比较所选择的两个光学混合相干信号，并且响应于比率的光学混合相干信号而产生图像，其可以显示为 一个用户

公开(公告)号：US07862507B2

公开(公告)日：2011-01-04

申请号：US11510898

申请日：2006-08-28

Applicant: Jonathan Mark Crowther ,  Peter Blenkiron ,  Paul Jonathan Matts ,  Anke Sieg

Inventor： Jonathan Mark Crowther ,  Peter Blenkiron ,  Paul Jonathan Matts ,  Anke Sieg

IPC: A61B5/00 ,  A61B6/00 ,  A61B5/103

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N2021/656 ,  G06Q30/0242 ,  G06Q30/0269

Abstract: Use of Confocal Raman Spectroscopy (CRS) for dermatological studies, including a method for determining the thickness of the Stratum Corneum (SC) on a test area of the skin, and to a method for quantifying the effectiveness of a skin care composition. The methods of the invention can be carried in vitro (either artificial skin or a sample of skin) or in vivo (directly on the human skin of a person).

Abstract translation: 共聚焦拉曼光谱法（CRS）用于皮肤病学研究，包括用于测定皮肤试验区域上的角质层（SC）的厚度的方法，以及用于量化皮肤护理组合物的有效性的方法。 本发明的方法可以在体外（人造皮肤或皮肤样品）或体内（直接在人的人皮肤上）进行。

公开(公告)号：US20100328665A1

公开(公告)日：2010-12-30

申请号：US12864064

申请日：2009-01-22

Applicant: Paul Henry Kaye ,  Warren Roy Stanley

Inventor： Paul Henry Kaye ,  Warren Roy Stanley

IPC: G01N21/00

CPC classification number: G01N21/532 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N15/1427 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/53 ,  G01N21/64 ,  G01N2015/0046 ,  G01N2015/0088

Abstract: There is disclosed improved apparatus and methods for detection of shape, size and intrinsic fluorescence properties of a fluid borne particle wherein the apparatus comprises a laser, two light sources, two detectors, and optionally a third detector. The apparatus is particularly suitable for detection of airbone biological particles.

Abstract translation: 公开了用于检测流体颗粒的形状，尺寸和固有荧光特性的改进的装置和方法，其中该装置包括激光器，两个光源，两个检测器和任选的第三检测器。 该装置特别适用于检测空中生物颗粒。

公开(公告)号：US07859661B2

公开(公告)日：2010-12-28

申请号：US12158323

申请日：2007-01-19

Applicant: Razvigor Ossikovski ,  Antonello De Martino ,  Bernard Drevillon

Inventor： Razvigor Ossikovski ,  Antonello De Martino ,  Bernard Drevillon

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0224 ,  G01N21/21 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/4792

Abstract: A Raman method and system for analysing a sample including an excitation source emitting an incident light beam, a sample holder for mounting the sample, elements for focusing the incident light beam onto the sample surface to generate a Raman scattered light having an intensity, elements for collecting the Raman scattered light to form a Raman scattered light beam, a detection system measuring intensity of the Raman scattered light beam as a function of time. The system includes at least a polarization state generator able to generate four independent polarization states or a polarization state analyzer able to analyze four independent polarization states to detect the intensity of the Raman scattered light beam and calculate a partial or complete Mueller-Stokes matrix of the sample.

Abstract translation: 用于分析包括发射入射光束的激发源的样品的拉曼方法和系统，用于安装样品的样品保持器，用于将入射光束聚焦到样品表面上的元件，以产生具有强度的拉曼散射光， 收集拉曼散射光以形成拉曼散射光束，测量拉曼散射光束的强度作为时间的函数的检测系统。 该系统至少包括能够产生四个独立极化状态的偏振状态发生器或能够分析四个独立极化状态以检测拉曼散射光束的强度的偏振状态分析器，并且计算部分或完整的米勒 - 斯托克斯矩阵 样品。

公开(公告)号：US20100315631A1

公开(公告)日：2010-12-16

申请号：US12797652

申请日：2010-06-10

Applicant: Xin Jack Zhou ,  Sean Xiaolu Wang

Inventor： Xin Jack Zhou ,  Sean Xiaolu Wang

IPC: G01J3/44

CPC classification number: G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/6419

Abstract: A Raman spectroscopic apparatus utilizing a self-aligned non-dispersive external cavity laser as the excitation light source. The output spectrum of the laser is narrowed and stabilized by a volume Bragg grating to provide high spectral brightness. A high throughput optical system is used for Raman scattering signal excitation and extraction, which takes full advantage of the high spectral brightness of the laser source.

Abstract translation: 利用自对准非分散外腔激光器作为激发光源的拉曼光谱仪。 激光的输出光谱由体积布拉格光栅变窄并稳定，以提供高光谱亮度。 用于拉曼散射信号激发和提取的高通量光学系统，其充分利用了激光源的高光谱亮度。

公开(公告)号：US20100315629A1

公开(公告)日：2010-12-16

申请号：US12724192

申请日：2010-03-15

Applicant: Kevin J. Knopp ,  Robert L. Green ,  Brendon D. Tower ,  Christopher D. Brown ,  Gregory H. Vander Rhodes

Inventor： Kevin J. Knopp ,  Robert L. Green ,  Brendon D. Tower ,  Christopher D. Brown ,  Gregory H. Vander Rhodes

IPC: G01J3/44 ,  G01J3/00 ,  G01N21/62 ,  G01N21/55 ,  G01N21/47 ,  G01N21/59

CPC classification number: G01N21/17 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/59 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/105 ,  G01N2201/125

Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine infotmation about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

Abstract translation: 公开了包括被配置为将辐射引导到样品的辐射源的装置，试剂盒，方法和系统; 检测器，被配置为测量来自样品的辐射; 配置为基于所测量的辐射来确定关于样本的信息的电子处理器; 包围所述源，所述检测器和所述电子处理器的外壳，所述外壳具有手持外形尺寸; 臂被配置为保持样品和壳体之间的分离，所述臂包括构造成连接到壳体的第一端和被配置为接触样品的第二端; 以及位于所述臂的第二端上的层，所述层被配置为接触所述样品并将所述辐射的至少一部分从所述样品透射到所述检测器。