公开(公告)号：US20210016269A1

公开(公告)日：2021-01-21

申请号：US17063067

申请日：2020-10-05

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  John H. Kepler ,  Gaurav Rohatgi ,  Philip Charles Walker ,  Mark Bates ,  Christopher James Page

IPC: B01L3/00 ,  G01N33/02 ,  G01N1/08 ,  G01N1/28 ,  G01N33/53

Abstract: The present invention provides systems, devices and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sample pickup, one or more disposables for receiving and processing a test sample and a detection device that can execute an allergen detection testing in minutes. The present detection system and device is compact and portable.

公开(公告)号：US20190292544A1

公开(公告)日：2019-09-26

申请号：US16347935

申请日：2017-11-08

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Valerie Villareal ,  Sarah Stidham ,  Morris Nehama

IPC: C12N15/115 ,  G01N33/02 ,  C12N15/10 ,  G01N33/533

Abstract: The present application discloses nucleic acid aptamer based signaling polynucleotides (SPNs) that specifically bind an allergen protein. Provided in the present invention include aptamers, SPNs, SPN-complement complexes, magnetic particle conjugates, DNA printed glass slides and detection agents, and detection methods using the same for detecting the presence, or absence of an allergen protein in a food sample.

公开(公告)号：US10344319B2

公开(公告)日：2019-07-09

申请号：US15030564

申请日：2014-10-28

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown

IPC: C12Q1/68 ,  C12Q1/6818 ,  C12Q1/6811 ,  G01N33/53 ,  C12N15/10 ,  G01N33/02

Abstract: The present invention provides allergen detection molecules and devices useful in on-site and rapid detection of allergens, including food allergens.

公开(公告)号：US20190079063A1

公开(公告)日：2019-03-14

申请号：US16084996

申请日：2017-03-10

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  Sarah Stidham ,  Valerie Villareal ,  Adam J. Young ,  Joshua Glenn Anthony ,  Patrick Murphy ,  John H. Kepler ,  Adam Jacobs

IPC: G01N33/02 ,  G01N33/53 ,  G01N33/58 ,  G01N1/28

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

公开(公告)号：US20180154350A1

公开(公告)日：2018-06-07

申请号：US15705328

申请日：2016-03-15

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown ,  John H. Kepler ,  Gaurav Rohatgi ,  Philip Charles Walker ,  Mark Bates ,  Christopher James Page

IPC: B01L3/00 ,  G01N33/02 ,  G01N1/08 ,  G01N33/53 ,  G01N1/28

CPC classification number: B01L3/502 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/0694 ,  C12Q1/6804 ,  G01N1/08 ,  G01N1/286 ,  G01N33/02 ,  G01N33/5308 ,  G01N2001/2866 ,  C12Q2525/205 ,  C12Q2563/107 ,  C12Q2565/1015 ,  C12Q2565/107

Abstract: The present invention provides systems, devices and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sample pickup, one or more disposables for receiving and processing a test sample and a detection device that can execute an allergen detection testing in minutes. The present detection system and device is compact and portable.

公开(公告)号：US20220298570A1

公开(公告)日：2022-09-22

申请号：US17636403

申请日：2020-08-20

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Valerie Villareal ,  Patrick Murphy ,  Nhat Nam Trinh

IPC: C12Q1/6876 ,  C12Q1/6834

Abstract: The present disclosure relates to optimized nucleic acid probes, nucleic acid chips, and assays and methods for detection of an analyte of interest in a sample, for example, an allergen in a food sample.

公开(公告)号：US11268136B2

公开(公告)日：2022-03-08

申请号：US16419150

申请日：2019-05-22

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown

IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/6818 ,  G01N33/02 ,  C12Q1/6811 ,  G01N33/53 ,  C12N15/115 ,  C12N15/10

Abstract: The present invention provides allergen detection molecules and devices useful in on-site and rapid detection of allergens, including food allergens.

公开(公告)号：US20190119669A1

公开(公告)日：2019-04-25

申请号：US16093200

申请日：2017-04-11

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown

IPC: C12N15/10 ,  C12Q1/6811 ,  G01N33/543

Abstract: The present invention relates to assays and methods for target analyte (e.g., allergen) detection in a sample using aptamer-magnetic particle complexes.

公开(公告)号：US20180128835A1

公开(公告)日：2018-05-10

申请号：US15569808

申请日：2016-04-26

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen

IPC: G01N33/58 ,  G01N33/68 ,  C12M1/34 ,  A61K38/00

CPC classification number: G01N33/582 ,  A61K38/00 ,  A61P37/00 ,  C12M1/34 ,  C12N2310/16 ,  G01N33/5308 ,  G01N33/542 ,  G01N33/68 ,  G01N2800/24

Abstract: The present invention is drawn to nucleic acid aptamer based signaling polynucleotides (SPNs) for allergen detection in samples. Disclosed herein include compositions, compounds, assays and methods of using said SPNs to detect one or more allergens in a sample, particularly food allergens in a food product.

公开(公告)号：US20240299940A1

公开(公告)日：2024-09-12

申请号：US18260600

申请日：2022-01-06

Applicant: DOTS Technology Corp.

Inventor： Adi Gilboa-Geffen ,  Renuka Babu Brown

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502738 ,  G01N33/54366 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/12 ,  B01L2400/0644

Abstract: The present disclosure is drawn to devices and systems for target detection in samples, including food samples, clinical samples, environmental samples and veterinary samples. The target detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system.