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公开(公告)号：US11034963B2
公开(公告)日：2021-06-15
申请号：US16347935
申请日：2017-11-08
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Valerie Villareal , Sarah Stidham , Morris Nehama
IPC: C12N15/115 , C12N15/10 , G01N33/02 , G01N33/533 , C12Q1/6816
Abstract: The present application discloses nucleic acid aptamer based signaling polynucleotides (SPNs) that specifically bind an allergen protein. Provided in the present invention include aptamers, SPNs, SPN-complement complexes, magnetic particle conjugates, DNA printed glass slides and detection agents, and detection methods using the same for detecting the presence, or absence of an allergen protein in a food sample.
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公开(公告)号：US20220298570A1
公开(公告)日：2022-09-22
申请号：US17636403
申请日：2020-08-20
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Valerie Villareal , Patrick Murphy , Nhat Nam Trinh
IPC: C12Q1/6876 , C12Q1/6834
Abstract: The present disclosure relates to optimized nucleic acid probes, nucleic acid chips, and assays and methods for detection of an analyte of interest in a sample, for example, an allergen in a food sample.
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公开(公告)号：US20210389245A1
公开(公告)日：2021-12-16
申请号：US17282807
申请日：2019-10-04
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Alan Lloyd Weeks , Valerie Villareal , Patrick Murphy , Eric Anthony Robertson , Deirdre Ellen Day , Matthew Bernard Dean , Todd Glendon Campbell , Brian Christopher Burke , Tyler S. Smith , Thomas Christopher Hartner , Stanley Owen Thompson , Nhat Nam Trinh , David Carpenter , Gregory J. Kintz , Paul Koh , David Jennings Dostal , Kevin Doherty , Joel F. Jensen , William Law , Russell C. Mead, Jr. , J. Efraín Alcorta
Abstract: The present disclosure is drawn to devices and systems for target detection in samples, particularly allergen detection in food samples. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. The allergen detection utilizes nucleic acid molecules as detection agents and detection probes.
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Patent Agency Ranking
公开(公告)号：US20210311032A1
公开(公告)日：2021-10-07
申请号：US16971701
申请日：2019-02-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Alan Lloyd Weeks , Valerie Villareal , Patrick Murphy , Eric Anthony Robertson , David Carpenter , Deirdre Ellen Day , Matthew Bernard Dean , Todd Glendon Campbell , Gregory J. Kintz , Paul Koh , David Jennings Dostal , Kevin Doherty , Joel F. Jensen , William Law , Russell C. Mead, Jr. , J. Efraín Alcorta
IPC: G01N33/53 , G01N33/543 , C12Q1/6816 , G01N33/02
Abstract: The present invention is drawn to devices and systems for allergen detection in food samples. The allergen detection system includes a disposable analysis cartridge and a detection device with an optimized optical system.
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公开(公告)号：US20210109076A1
公开(公告)日：2021-04-15
申请号：US17128270
申请日：2020-12-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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公开(公告)号：US10908139B2
公开(公告)日：2021-02-02
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
IPC: B01L3/00 , B01L1/00 , G01N33/02 , C12M1/34 , G01N1/08 , C12N15/115 , G01N1/14 , G01N1/28 , G01N33/53 , G01N33/58
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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公开(公告)号：US20190292544A1
公开(公告)日：2019-09-26
申请号：US16347935
申请日：2017-11-08
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Valerie Villareal , Sarah Stidham , Morris Nehama
IPC: C12N15/115 , G01N33/02 , C12N15/10 , G01N33/533
Abstract: The present application discloses nucleic acid aptamer based signaling polynucleotides (SPNs) that specifically bind an allergen protein. Provided in the present invention include aptamers, SPNs, SPN-complement complexes, magnetic particle conjugates, DNA printed glass slides and detection agents, and detection methods using the same for detecting the presence, or absence of an allergen protein in a food sample.
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公开(公告)号：US20190079063A1
公开(公告)日：2019-03-14
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
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